Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Dr. Vikki Petersen D.C, C.C.N
    Dr. Vikki Petersen D.C, C.C.N

    Gluten Sensitivity and Depression

    Reviewed and edited by a celiac disease expert.

    This article originally appeared in the Spring 2009 edition of Open Original Shared Link

    Celiac.com 03/02/2009 - Patients with depression are told they have a chemical imbalance.  If someone else in their family is also depressed, the “gene card” is played.  “Your depression is genetic”, they are told.

    Celiac.com Sponsor (A12):
    I have been in practice for over 20 years and I find the above data to be false.  Consistently we find patients who are suffering from depression and anxiety to be gluten sensitive. How could a food cause depression?  Let’s take a look.

    After the digestive tract, the most commonly affected system to be affected by gluten is the nervous system. It is thought that depression can be caused by gluten in one of two ways.  

    The first area addresses the inflammatory changes gluten can cause. A gluten sensitive individual’s immune system responds to the protein gliadin.  Unfortunately, that protein is similar in structure to other proteins present in the body, including those of the brain and nerve cells. A cross reactivity can occur whereby the immune system “confuses” proteins in the body for the protein gliadin.  This is called cellular mimicry and the result is the body attacking it’s own tissues with inflammation resulting. When inflammation happens in the brain and nervous system, a variety of symptoms can occur, including depression. Research shows us that patients with symptoms involving the nervous system suffer from digestive problems only 13% of the time.  This is significant because mainstream medicine equates gluten sensitivity almost exclusively with digestive complaints.

    In a study examining blood flow to the brain, 15 patients with untreated celiac disease were compared to 15 patients treated with a gluten-free diet for a year.  The findings were amazing. In the untreated group, 73% had abnormalities in brain circulation by testing while only 7% in the treated group showed any abnormalities. The patients with the brain circulation problems were frequently suffering from anxiety and depression as well.

    In addition to circulation problems, other research looks at the association between gluten sensitivity and its interference with protein absorption.  Specifically the amino acid tryptophan can be deficient. Tryptophan is a protein in the brain responsible for a feeling of well-being and relaxation. A deficiency can be correlated to feelings of depression and anxiety.

    Our society is too willing to accept a “chemical imbalance” as an explanation for their symptoms and instead of getting to the root cause of the condition, simply swallow a pill – a pill that in the case of anti-depressants has very dangerous and sometimes lethal side effects.

    The frequency with which we are able to successfully taper patients off their anti-depressants is considered “unbelievable” to many mainstream doctors, yet we do it regularly.  How is that possible?  We actually diagnose the root cause of the depression.  Frequently the culprit is gluten, and in such cases a gluten-free diet is the main path to recovery.



    User Feedback

    Recommended Comments



    Guest Kristen

    Posted

    Great article! It is very encouraging to read about atypical symptoms of gluten sensitivity, it is important for people to know that digestive problems are not the only symptoms.

    Link to comment
    Share on other sites
    Guest laura

    Posted

    Fantastic article. I was diagnosed with celiac disease a year ago with few digestive symptoms. Looking back on my year I feel like I've finally come out of a depression that lasted for years and I know it is due to cutting out the gluten. I would love to read the study.

    Link to comment
    Share on other sites
    Guest Dr Vikki Petersen

    Posted

    To answer Laura's request to be able to read the study I quoted in the above article, here it is:

    G. Addolorado, 'Regional Cerebral Hypoperfusion in Patients with Celiac Disease,' The American Journal Of Medicine 116 (2004):312-7.

    The data truly is amazing. Enjoy!

     

    To your good health,

    Dr Vikki Petersen

    Link to comment
    Share on other sites
    Guest Amber

    Posted

    Wonderful article. It's time for society to wake up and stop sweeping our troubles under a rug. Let's get rid of the 'band-aid concept' all together.

    Link to comment
    Share on other sites
    Guest laura

    Posted

    THANK YOU Dr. Petersen! This article is potentially life saving for those of us who suffer from severe mood disorders. It is wonderful to realize that I am coming 'out of the dark' in regards to my bipolar disorder. Just yesterday, I tested positive to gluten intolerance. Frankly, I was not surprised. If this is indeed the reason for my mood instability, then I have found the missing piece to the puzzle I have fought two decades to solve. I just wish the word would spread faster! So many that are suffering from 'Bandaid treatment'-which helps very little and hinders a lot-could stop the dead end cycle of 'cures' that actually do harm. Doctors need to give this study more credit and help their patients have more hope for improvement and possible recovery. A life time of psychiatric pills should be saved as a last resort.

    Link to comment
    Share on other sites
    Guest Rachel

    Posted

    This is wonderful insight! I've been handed the 'gene card' many times. Interestingly enough, many of my family also are sensitive to milk and wheat and high gluten grains. My husband has been eating a low gluten diet and 'coincidentally' my mental health has been better. Thank you Dr. Petersen for sharing this info with us!

    Link to comment
    Share on other sites
    Guest Hal

    Very good article and I can attest to the feelings of depression brought on by gluten. Trouble is they don't bother to test people with depression who haven't already been branded with the CS or Gluten allergy/intolerance, and treat them drugs.

    Link to comment
    Share on other sites
    Guest Sage

    This was my first visit to the site, well written article. I suffer from Bi polar, diagnosed 4 years ago, and CS 6 months ago. I always new something wasn't right, and 2 years ago they said I had migraines! I am starting nursing school soon and I hope that more doctors look at diagnosing from more than just one angle. I know I will be researching it further to find out how much is part of the mood disorder and how much is CS for my Bi Polar. The migraines are gone since I went gluten-free. Once again, Thank you, it is hard to find good info. and your providing the journal where we can read the original findings adds to your credit.

    Link to comment
    Share on other sites
    Guest Julie

    Finally an answer that has taken me over 30 years to find! I have suffered with episodes of severe depression since I was 14 years old. I knew there had to be a link to my diet but couldn't find the key ingredient. Even after I was diagnosed with gluten intolerance at age 28 no one told me about the link to depression so I continued the search. Now I know I am not going crazy and have proof to show everyone else.

    Link to comment
    Share on other sites
    Guest Rusty

    I never knew this. I still have some slight amount of gluten in my diet, with most removed. Been this way for three years and my health has improved dramatically, with no overt symptoms for quite some time. However, I have had problems with anxiety and occasional depression which did not make much sense. Now it does. Looks like it's time to remove the last instances of gluten from my diet.

    Link to comment
    Share on other sites
    Guest monica ryan

    Posted

    I read about the link about gluten and depression. I ate a gluten-free diet and within two days my depression was gone. I had no physical symptoms of a gluten sensitivity. A food allergy test did not show up gluten as a problem and I am not celiac. I am so relieved!

    Link to comment
    Share on other sites
    Guest Jim

    I have suffered tremendously for two years now with severe anxiety and depression. I lost everything i.e house, career, credit rating and my mind. Just got diagnosed GS last week and was so relieved by articles like this one! I know going gluten free is tough, but I am willing to do anything to improve my mental/emotional health.

    Link to comment
    Share on other sites



    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Dr. Vikki Petersen D.C, C.C.N

    Dr. Vikki Petersen, a Chiropractor and Certified Clinical Nutritionist is co-founder and co-director, of the renowned HealthNow Medical Center in Sunnyvale, California. Acclaimed author of a new book, "The Gluten Effect" - celebrated by leading experts as an epic leap forward in gluten sensitivity diagnosis and treatment. Dr. Vikki is acknowledged as a pioneer in advances to identify and treat gluten sensitivity. The HealthNOW Medical Center uses a multi-disciplined approach to addressing complex health problems. It combines the best of internal medicine, clinical nutrition, chiropractic and physical therapy to identify the root cause of a patient's health condition and provide patient-specific wellness solutions. Her Web site is:
    www.healthnowmedical.com


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    Source: Scandinavian Journal of Gastroenterology, 18:(2):299-304, 1983 Mar.
    Authors - Hallert C., Astrom J., Walan A.

    Signs of mental depression are typical in adults with coeliac disease. The response to treatment was evaluated in 12 consecutive patients by means of the Minnesota Multiphasic Personality Inventory (MMPI), with surgical patients serving as controls. The coeliacs reported no change in depressive symptoms after 1 years gluten withdrawal despite evidence of improvement in the small intestine. When re-tested after 3 years, however, after 6 months of 80mg/day of oral pyridoxine (vitamin B6) therapy, they showed a fall in the score of scale 2 (depression) from 70 to 56 (p less than 0.01), which became normalized like other pretreatment abnormalities in the...


    Scott Adams
    The Journal of Psychosomatic Research
    Volume 55, Issue 6, Pages 573-574 (December 2003) Celiac.com 12/19/2003 - According to Italian researchers, brief but recurring bouts of depression and other mood disorders are significantly more common in those with celiac disease than those without the disorder. The researchers conducted a study that looked at 36 clinically diagnosed celiac disease patients and compared them to 144 healthy controls. The study found that those with celiac disease had "significantly elevated risks for major depressive disorders," including major depressive disorders, dysthymic disorders, adjustment disorders and panic disorders. The researchers suspect malabsorption of tryptophan, which can lead to a decrease in serotonin synthesis, as a cause for the elevated...


    Jefferson Adams
    Celiac.com 03/15/2008 - For the first time, medical researchers have shown that an activation of the inflammatory response system accompanies major depression and that pro-inflammatory cytokines and lipopolysaccharide (LPS) may trigger symptoms of depression. In the face of the study results, researchers are recommending that patients with depression be screened for leaky gut using IgM and IgA panels.
    Researchers set out to determine the role played by increased gastrointestinal permeability coupled with an increased translocation of LPS from gram-negative bacteria in the pathophysiology of major depression (MDD). The researcher team was made up of M. Maes, M. Kubera, J.C. Leunis. The team created a study to evaluate serum levels of IgM and IgA against LPS of the gram-negative enterobacteria...


    Jefferson Adams
    Higher Suicide Rates in Celiac Disease Patients
    Celiac.com 10/03/2011 - A number of studies show that people with celiac disease have higher risk of depression and death from external causes, but there are no conclusive studies on death from suicide.
    A research team set out to more deeply examine the risk of suicide in people with celiac disease. The team included J. F. Ludvigsson, C. Sellgren, B. Runeson, N. Långström, and P. Lichtenstein. They are affiliated with the Department of Paediatrics at Örebro University Hospital in Sweden.
    The team examined suicide risk in individuals with celiac disease where the small intestinal biopsy showed no villous atrophy.
    For their study, the team collected biopsy data from all 28 clinical pathology departments in Sweden for 29,083 individuals diagnosed during 1969-2007 with ce...


  • Recent Activity

    1. - trents replied to Therockfrog's topic in Related Issues & Disorders
      1

      Itchy skin, tingling in feet and scalp

    2. - Therockfrog posted a topic in Related Issues & Disorders
      1

      Itchy skin, tingling in feet and scalp

    3. - HWB replied to HWB's topic in Related Issues & Disorders
      14

      strange symptoms/ diagnosis accuracy

    4. - MomofGF replied to MomofGF's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      4

      Not sure if this is Celiac or just a gluten-free intolerance


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      125,709
    • Most Online (within 30 mins)
      7,748

    Vinnyb
    Newest Member
    Vinnyb
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.8k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • MomofGF
    • Louise Broughton
      4
    • marip
      4
    • sh00148
      19
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...