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    Jefferson Adams
    Jefferson Adams

    By Jefferson Adams •

    Celiac Disease May Cause Idiopathic Portal Hypertension

    Reviewed and edited by a celiac disease expert.

    Celiac.com 04/07/2009 - Idiopathic portal hypertension is a malady ofunknown cause, typically manifesting portal hypertension, splenomegalyand anemia secondary to hypersplenism.

    Recently, a team ofIranian researchers encountered the case of a a 54-year-old maleadmitted for evaluation of malaise, weight loss, abdominal swelling andedema of the lower limbs.

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    The reporting team was made up ofdoctors Farhad Zamani, Afsaneh Amiri, Ramin Shakeri, Ali Zare, andMehdi Mohamadnejad, of the Department of Pathology, and theGastrointestinal and Liver Disease Research Center of FirouzgarHospital at the University of Medical Sciences in Tehran, and theDigestive Disease Research Center of Shariati Hospital at TehranUniversity of Medical Sciences.

    The patient's clinicalevaluation showed pancytopenia, large ascites, splenomegaly andesophageal anomalies associated with portal hypertension.

    Bloodtests and small intestinal biopsy showed the presence of celiacdisease. Patient's symptoms improved with a gluten-free diet, butimprovement was further impaired by ulcerative jejunoileitis, andintestinal T-cell lymphoma.

    From these results, the researchersconclude that celiac disease, by means of a heightened immune responsein the splenoportal axis, can lead to the development of idiopathicportal hypertension in susceptible affected patients.

    J Med Case Reports. 2009; 3: 68.


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    Guest David Lapham Sr

    Guest David Lapham Sr

    Posted

    Good information. Would like to know more of the symptoms though.

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    Guest A.J.

    There is the use of too many medical terms that the average reader doesn't know the meaning of, therefore reading this article by anyone other than a medical student or doctor is like reading in a foreign language that you don't know. It's a waste of time to the average person who is dealing with celiac.

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    Guest Connie

    Guest Connie

    Posted

    What does all of this mean? I am struggling with extended symptoms and I just don't understand what this is all about? Perhaps this means me?

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    Guest L.N.

    I agree with A.J. - all this article does is freak me out! What do all those medical terms mean?? The only bits I understand are Coeliac and anaemia (both of which I have).... should I be worried about this mysterious idiopathic portal hypertension?!

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    Guest Brenda

    Guest Brenda

    Posted

    What causes what?? Ok celiac I get... beyond that...

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    Guest Raymond Craig

    Guest Raymond Craig

    Posted

    I agree with David. It would be helpful to know more about this one case before drawing a strong conclusion based on a somewhat vague phrase like 'susceptible adults.' What might make them susceptible? Just celiac disease? If so, where are all the other cases?

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    Guest Dick Wilkins

    Guest Dick Wilkins

    Posted

    I agree with #2. I still don't know what he was talking about. I don't know how to compare with my condition to see if I should investigate further.

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    Guest Jannice Gentry

    Guest Jannice Gentry

    Posted

    I could not understand the meaning of this article, there are so many medical terms I do not understand.

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    Guest Brandi Grev

    Guest Brandi Grev

    Posted

    Those of us looking for answers are sadly left feeling frustrated by this article.

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    Guest Willa Reddig

    Guest Willa Reddig

    Posted

    I agree with all the previous entries, and now I'm worried I might have something, because I just can't get to feeling up to par.

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    Guest Robena

    Totally agree with all of the above. How can I interpret whether it pertains to me or not, when I can't understand 90% of what I am reading.

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    Guest Nicholas

    Guest Nicholas

    Posted

    I have celiac and have and enlarged spleen, portal hypertension and cirrhosis of the liver. I am not a drinker and have had it since I was 21. So I believe without question it causes portal hypertension if left undiagnosed.

     

    Thank you for writing up something so rarely noted in medicine journals but which is so important.

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     

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