Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    Celiac Vaccine Clears First Big Clinical Trial

    Reviewed and edited by a celiac disease expert.

    Will a vaccine work against celiac disease?

    Celiac Vaccine Clears First Big Clinical Trial - Photo: Andres Rueda
    Caption: Photo: Andres Rueda

    Celiac.com 04/03/2017 - Massachusetts biotech firm ImmusanT has announced the successful completion of its first phase 1b trial of Nexvax2, an immunotherapy drug designed to protect celiac sufferers from the adverse effects of gluten exposure, including gastrointestinal symptoms, such as diarrhea, abdominal pain and bloating.

    Nexvax2 is a drug that relies on three peptides designed to promote T cells involved in the inflammatory reaction in celiac disease to become tolerant to gluten. The company hopes that an initial course will promote gluten-tolerance, which can then be maintained by periodic boosters of the vaccine.

    Celiac.com Sponsor (A12):
    The phase 1b trial in 38 patients showed no issues with safety or tolerability, and indicated that the immunotherapy seemed to work as designed.  The study also helped ImmusanT to determine dosages for phase 2 trials to determine if Nexvax2 can protect patients on a gluten-free diet from inadvertent gluten exposure, which ImmusanT sees as the quickest route to approval.

    If Nexvax2 proves to be effective in preventing accidental gluten exposure in celiac patients, the company plans a follow-up program to see if immunotherapy with Nexvax2 can eliminate the need for a gluten-free diet in celiac patients; a step that represents a daunting challenge, and is somewhat of a Holy Grail for celiac researchers.

    ImmusanT is also developing diagnostic protocols for the vaccine, which are designed to guide its use and help improve diagnosis rates.

    Nexvax2 is just the latest in a large crop of auxiliary treatments aimed at celiac disease. Switzerland's Anokion teamed up with Japanese pharma Astellas in 2015 to form Kanyos, a company working on an immunotherapy for celiac disease along with type 1 diabetes. A company called Sanofi is also working with Selecta on a similar approach.

    Meanwhile, in 2013 AbbVie licensed rights to Alvine Pharmaceuticals AVL003, an oral therapy designed to break down gluten in the GI tract before it can cause damage.

    So, stay tuned celiac sufferers, the next few years could produce some very interesting new treatments for celiac disease, something considered impossible just ten years ago.

    Source: Fierce Biotech



    User Feedback

    Recommended Comments



    Guest Sara P

    Posted

    Krispy Kreme for a week if this becomes a reality!

    Link to comment
    Share on other sites
    Guest Christina Sirr

    Posted

    Sure get a vaccine that supposedly cures an autoimmune disease that was most likely caused by vaccines...makes sense if you don't mind following the big pharma religion to the grave.

    Link to comment
    Share on other sites
    Guest CATRYNA WHITE

    Posted

    Take Sanofi out and shoot them. Now they have developed a BS vaccine to cure an auto immune disease that was caused by vaccines, in the first place. My hope is that no one is fooled by this enormous lie. Those of us who are gluten intolerant or celiac don't need this garbage. With proper diet we are improving our health and we don't need you or your filth!

    Link to comment
    Share on other sites
    Guest admin

    Posted

    Take Sanofi out and shoot them. Now they have developed a BS vaccine to cure an auto immune disease that was caused by vaccines, in the first place. My hope is that no one is fooled by this enormous lie. Those of us who are gluten intolerant or celiac don't need this garbage. With proper diet we are improving our health and we don't need you or your filth!

    Vaccines do not cause autoimmune diseases, this is a fully debunked myth.

    Link to comment
    Share on other sites
    Guest Brent

    Posted

    Great news. Let's hope the next phase works too as being coeliac is a living hell and want to be free of worry about food and live again.

    Link to comment
    Share on other sites
    Guest Dan

    I've lived with celiac and Crohn's all my life and for the nay-sayers on this list, get with the program. There are so many other dangerous side-effects due to inflammation and not related to stomach-aches and frequent bathroom stops that are scary. I've managed my entire life of 62 years and believed the same thing in my younger years. One example is blood clots in my legs due to inflammation affecting my aorta causing it to throw out clots. I've never smoked or had even a single drink of alcohol my entire life and my cholesterol is great and blood pressure is almost always perfect so doctors were confused why I had arterial clotting in my leg and believe it's all related to inflammation from both Crohn's and celiac. We all need to encourage researchers to keep up the good work! I do agree that drug companies have received well deserved criticism and wish the government would see healthcare as important as gun rights!

    Link to comment
    Share on other sites
    Guest Robyn

    Posted

    This is AMAZING news! Having had Celiac for about 16 years now, I have been hoping and praying for something like this for SO long. I rarely look forward to events where food is being served because of the obvious. While eating gluten-free has certainly improved over the last several years, if this vaccine works, AND is safe (for those who somehow see this vaccine as a negative thing!) it will change so many lives making the almost inevitable/accidental cross contamination a thing of the past so that we can be healthier! Plus, it will make going to parties, and everything involved around food, a true joy again! Thanks for the great news and, hopefully, keep it coming!!

    Link to comment
    Share on other sites
    Guest Chattanooga Charlie

    Posted

    I have never see any meaningful info that vaccines cause Coeliac disease. Many vaccines do have some possible bad or no helpful outcomes for a certain set of recipients. I had to go to ER after a Flu vaccine. I have the gene that says that I am high risk for Coeliac disease. My father died from Coeliac disease. In any case, I would be very leery of anything involving autoimmunity. There are many of the new autoimmune biologics that can have very serious consequences. A very well regarded Endocrinologist along with others see Coeliac disease patients with other autoimmune disorders. I would want to know the possible bad effects before even considering such a vaccine.

    Link to comment
    Share on other sites
    Guest Mark
    Take Sanofi out and shoot them. Now they have developed a BS vaccine to cure an auto immune disease that was caused by vaccines, in the first place. My hope is that no one is fooled by this enormous lie. Those of us who are gluten intolerant or celiac don't need this garbage. With proper diet we are improving our health and we don't need you or your filth!

    Catryna White - Celiac disease was first identified in ancient Greece - they didn't have vaccines! Celiac health improved during World Wars due to lack of flour. If you look at the history of celiac disease and it's genetic trait you wouldn't believe such rubbish.

    Link to comment
    Share on other sites
    Guest Anne

    Yes, thank you! Vaccines do NOT cause autoimmune disease. I am a health care professional and I wish that more of us would speak out against this myth!

    Link to comment
    Share on other sites
    Guest Debbie Stevens

    Posted

    Gluten is destructive for many people. Why develop a vaccine against it? Get rid of the glyphosate soaked wheat! Get to the root cause of the problem. We need food that is healthy and nutritious, not harmful to us.

    Link to comment
    Share on other sites
    Guest coloradosue

    Posted

    Question: Is there a treatment that now stops the immediate reaction to gluten and also stops damage occurring to the villi? The treatments that are being tested in the article seem to be singular instead of all inclusive. And how much will these treatments cost? If the high cost of the testing device is any indication, we are looking breaking the bank just to eat "bread". I will continue to be gluten free via diet which is free. - sorry didn't mean to do any rhyming here.

    Link to comment
    Share on other sites



    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 07/25/2016 - Celiac disease is one of the most common immune-mediated diseases. Often, a gluten-free diet does not fully control celiac symptoms and disease activity.
    Even though no new therapies have been approved, a growing effort, coupled with a rapidly expanding knowledge of the regulatory pathway could soon lead to new breakthroughs.
    A team of researchers recently reviewed the epidemiology, pathophysiology, and current treatment paradigm for celiac disease. The researchers were M Wungjiranirun, CP Kelly, and DA Leffler, both of the Division of Gastroenterology at the Celiac Center of Beth Israel Deaconess Medical Center in Boston, Massachusetts, USA.
    They also reviewed the major types of therapies being proposed for celiac treatment, and expounded broadly upon...


    Jefferson Adams
    Celiac.com 07/19/2016 - The world's first vaccine aimed at curing celiac disease is slated to begin full trials later this year, and residents of the Australian state of Victoria will be among the first humans to give it a try against celiac disease.
    The vaccine, called Nexvax2, was developed by Australian scientist Dr Bob Anderson, and is aimed at giving celiac patients a chance to overcome their immune reaction to the gluten found in products containing wheat, rye and barley. Nexvax2 aims to de-sensitise patients to three peptides contained in gluten that trigger a damaging reaction in their immune system.
    Previous trials on 150 patients from Melbourne, Perth, Adelaide, Brisbane and Auckland were aimed at finding a safe dosage rather than assessing its ability to beat celiac disease...


    Jefferson Adams
    Takeda Taps PvP Biologics to Develop Celiac Disease Therapy
    Celiac.com 03/10/2017 - PvP Biologics, a business spun out of the University of Washington, now has a $35 million deal with Takeda Pharmaceutical to develop its therapy for celiac disease. PvP Biologics is developing an enzyme that can be taken orally and survive in the harsh acidic environment of the stomach. That enzyme is called KumaMax.
    Under the terms of the agreement, Takeda will fund $35 million in PvP's research and development of the therapy through phase 1 clinical trials. The agreement gives Takeda Pharmaceutical the exclusive option to acquire PvP for an undisclosed fee upon successful completion.
    PvP Biologics has its roots in a University of Washington tech incubator program, but spun out on its own in 2016, in advance of its arrangement with Takeda.
    Says Adam Simpson...


    Jefferson Adams
    Enzyme Shows Promise In Dissolving Gliadin Peptides in Celiac Patients
    Celiac.com 03/27/2017 - A number of researchers are looking to provide alternative or adjunct treatments to the gluten-free diet in celiac disease. Meanwhile, a number of companies are currently developing a wide variety of such options, ranging from various kinds of enzyme therapies, to treatments that eliminate celiac disease reactions, even to vaccines to inoculate celiac sufferers against their condition, perhaps allowing for full recovery and a return to non-gluten-free eating habits, as desired. At least, that's one dream.
    More likely will be the development of enzymes or other treatments that offer celiacs varying degrees of protection from gluten ingestion. Most likely, such treatments would be designed to augment an existing gluten-free diet, and to provide protection against...


  • Recent Activity

    1. - Scott Adams replied to Brianne03's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      1

      Daughter recently diagnosed with Celiac and I am questioning my results...

    2. - BertoleAmur replied to Rosyjo11's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Has anyone found Ozempic affected their symptoms?

    3. - Scott Adams replied to CeliacChica's topic in Related Issues & Disorders
      28

      Muscle Twitching

    4. - aperlo34 replied to CeliacChica's topic in Related Issues & Disorders
      28

      Muscle Twitching

    5. - Yaya replied to CeliacChica's topic in Related Issues & Disorders
      28

      Muscle Twitching


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,019
    • Most Online (within 30 mins)
      7,748

    TryingHardToGoGlutenFree
    Newest Member
    TryingHardToGoGlutenFree
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.1k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Brianne03
    • gregoryC
    • CeliacChica
      28
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...