Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    Can Scientists Find Acceptance for GMO Gluten-Free Wheat?

    Reviewed and edited by a celiac disease expert.

    Will people buy GMO gluten-free wheat? The people developing it think so.

    Can Scientists Find Acceptance for GMO Gluten-Free Wheat? - Photo: CC--Brad Higham
    Caption: Photo: CC--Brad Higham

    Celiac.com 01/08/2018 - Imagine gluten-free wheat. Well, actually you don't have to imagine it, because a group of scientists has used a gene-editing technique called CRISPR/Cas9 to cut selected genes from a wheat genome, and presto, gluten-free wheat is a thing.

    As people in numerous countries debate genetically modified crops, some countries, including France and Germany, have passed laws to prohibit their cultivation.

    Celiac.com Sponsor (A12):
    Remember, we're not talking about hybridization here, which is based on natural selection and works by interbreeding plant strains. Researchers have used hybridization to develop strains of wheat that are low in gluten, but so far no one has made a strain that is entirely free of gluten.

    In this case, we're talking about genetic modification; changing the basic genetic structure of the plant. The greatest objections around GMO practices have been focused on the insertion of DNA from one species into another species, says Francisco Barro, a plant biotechnologist at the Institute for Sustainable Agriculture in Spain.

    To steer clear of this genetic process, Barro and his team used the gene-editing technique CRISPR/Cas9 to remove certain genes from a wheat genome. Their team focused on alpha-gliadins, gluten proteins that are thought to be the trigger for immune system reactions in people with celiac disease and gluten sensitivity.

    To accomplish their goal of removing the culprit gene(s), the research team used the scissorlike Cas9 protein to cut out 35 of the 45 alpha-gliadin genes. Lab tests showed that the new wheat strain reduced the immune response by 85 percent, the team reported.

    Far from being any kind of decisive breakthrough though, this is just one “really important step in maybe producing something that is going to be incredibly useful,” says Wendy Harwood, a crop geneticist at the John Innes Center in England.

    Meanwhile, Barro says his team is working on targeting more gluten-triggered genes to develop a completely safe strain of wheat for celiac patients.

    Source:



    User Feedback

    Recommended Comments

    Guest Michael

    Posted

    Once again, I have to point out the overwhelming ignorance of "scientists". Dr. Tom O'Bryan has switched from talking about "gluten sensitivity" to "wheat sensitivity" after researchers at Columbia University have identified five more categories of proteins in wheat that celiacs react to, in addition to prolamins and glutelins as gliadin and glutenin. My diagnosing physician has told me that someone born with celiac disease but not diagnosed until late in adulthood will react to every part of wheat and many things that the patient ate with wheat. She said that there is a "Pavlov's dog" effect on the immune system. And in view of the mistake at the General Mills factory of using wheat flour in Cheerios, how can anybody trust that gluten-free wheat will be used instead of regular wheat. And how can you think that gluten-free wheat will not be cross-pollinated by regular wheat? And what good will gluten-free wheat be to anyone? It will just be gross cardboard dust.

    Link to comment
    Share on other sites
    Guest CJ Russell

    Posted

    My father was a chemist and one of my brother's worked with scientists who were developing GMO grains 30 years ago. I don't have the 'GMOs are dangerous and scary' mindset. I am totally in favor of science finding solutions to my health issues. It is true that "gluten sensitivity", "gluten allergy", and "wheat sensitivity" are different things, so this particular breakthrough may not help every gluten sensitive person, but I believe that it is a step in the right direction.

    Link to comment
    Share on other sites
    Guest Liz

    Thanks for this article. I think we're wasting the potential of GMO foods on things like Roundup Ready Corn. I would be in favor of gluten-free wheat, but this article says it reduces the response by 85%. That may not be enough for those who already have it. It might be better as a preventative to reduce the incidence of celiac disease in those who haven't developed it yet. If it were adopted as the wheat used in processed foods, then it could potentially do a world of good to everyone by not exposing them and not sensitizing them in the first place. I think that for me, I am too far gone to be helped, but I'd love to imagine a future for my family in which they have never heard of celiac. To do that, it will also be necessary to make gluten-free barley and rye, and possibly oats. Oats are still in the gray area of gluten-free because some people react to avenin. If embraced, this could really give us a better future.

    Link to comment
    Share on other sites
    Guest Pau

    And what exactly would be the use of gluten-free wheat? Without gluten, it won't be any better in making bread and pastry than any other naturally gluten-free grains. Try making bread with wheat strains that only contain 3% of gluten and you will see for yourself, and I assume that is still way more gluten than the gluten-free would have. Another issue will be to keep the crop uncontaminated because it will probably look the same as regular wheat, maybe adding a gene to make it resistant to some herbicide will solve that? Yummy. Not worth the effort.

    Link to comment
    Share on other sites


    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Is Gluten-free Wheat the Holy Grail of Grain Research?
    Celiac.com 05/04/2015 - Kansas farmers grow a lot of wheat. People with celiac disease avoid wheat like the plague. Not only are people with celiac disease avoiding wheat, but the vast majority of people who avoid wheat now do so for non-medical reasons.
    With celiac disease rates on the rise, and millions of non-celiacs now avoiding gluten for non-medical reasons, the gluten-free food industry is worth nearly a billion dollars a year in the U.S. alone.
    This reality has wheat farmers and researchers scrambling to develop wheat strains and products that are safe for consumption by people who follow gluten-free diets.
    If the The Kansas Wheat Commission has its way, people with and without celiac disease will eat gluten-free wheat in the future. The Commission is providing...


    Jefferson Adams
    Are Celiac-safe Wheat Crops the Wave of the Future?
    Celiac.com 03/22/2017 - A new study published in the journal Food Chemistry shows that even the ancient varieties of wheat that have not been subject to hybridization, contain toxic epitopes that trigger adverse autoimmune response in celiac patients.
    What makes gluten toxic to people with celiac disease? Also, what is the relationship between various kinds of wheat and their celiac toxicity?
    To answer those questions, a team of researchers analyzed various kinds of wheat from several countries, all produced in the same agronomic year (2013-2014) at the Experimental Station at the Agronomic, Food and Biosystems School of Madrid.
    Their study focused on a specific set of proteins in gluten, called gliadins. Marta Rodríguez-Quijano, a researcher at the Technical University of Madrid ...


    Jefferson Adams
    Low Wheat Prices Have Some Investors Betting Big on Gluten-free Grains
    Celiac.com 06/01/2017 - With low prices and slim margins, life is tough for people who trade in wheat, corn and soybeans these days. So much so that some traders are turning to obscure commodities like desert-grown tomatoes and chickpeas to turn a profit.
    Over the last several years, as farmers have produced far more of these crops than the marker can handle, margins for handling major grain crops have sunk. That has led some trading firms to seek higher margins in niche markets, such as tomatoes and organic grains, while other firms are looking to organic grains, and markets for costlier processed food ingredients or gluten-free products.
    One such company is Germany's BayWa AG. According to Jean-Francois Lambert, the founder and managing partner of consultant Lambert Commodities...


    Jefferson Adams
    Researchers Use CRISPR/Cas9 to Produce Low Gluten Wheat Strains
    Celiac.com 10/25/2017 - For people with celiac disease, eating gluten proteins from wheat, barley, and rye triggers an auto-immune response, and the accompanying physical symptoms.
    A team of researchers recently set out to engineer low-gluten wheat strains that also have low-reactivity for people with celiac disease. To meet their goals, the team designed two sgRNAs to target a conserved region adjacent to the coding sequence for the 33-mer in the -gliadin genes. They then sought to evaluate the results.
    The research team included Susana Sánchez-León, Javier Gil-Humanes, Carmen V. Ozuna, María J. Giménez, Carolina Sousa, Daniel F. Voytas, and Francisco Barro. They are variously affiliated with the Departamento de Mejora Genética Vegetal, Instituto de Agricultura Sostenible (IAS-CSIC...


  • Recent Activity

    1. - cristiana replied to jadeceoliacuk's topic in Doctors
      3

      How to choose a Naturopath for 6yr old

    2. - jadeceoliacuk replied to jadeceoliacuk's topic in Doctors
      3

      How to choose a Naturopath for 6yr old

    3. - Wheatwacked replied to Gluten is bad's topic in Gluten-Free Foods, Products, Shopping & Medications
      7

      Gluten Free ADHD medications

    4. - pasqualeb replied to pasqualeb's topic in Related Issues & Disorders
      13

      Muscle atrophy in legs

    5. - pasqualeb replied to pasqualeb's topic in Related Issues & Disorders
      13

      Muscle atrophy in legs


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      125,905
    • Most Online (within 30 mins)
      7,748

    AnnieG
    Newest Member
    AnnieG
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Gluten is bad
      7
    • gemknorodo
      5
    • Pua
      9
    • pasqualeb
      13
    • gregoryC
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...