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  • Scott Adams
    Scott Adams

    A Gluten-Free Diet May Not Stop Gut Inflammation for all Celiac Disease Patients

    Reviewed and edited by a celiac disease expert.

    New study shows that a gluten‐free diet may not be enough to curb gut inflammation in all celiac disease patients.

    A Gluten-Free Diet May Not Stop Gut Inflammation for all Celiac Disease Patients - Image: CC BY 2.0--Güel - Centro de Wellness Murcia
    Caption: Image: CC BY 2.0--Güel - Centro de Wellness Murcia

    Celiac.com 03/08/2021 - When people with celiac disease eat gluten, it triggers adaptive immune cells, which cause damage to the lining of the small intestine. Doctors gauge the severity of celiac disease through histological assessment of the intestinal damage via intestinal biopsy. To confirm diagnosis and to test drug efficacy in clinical trials, doctors rely on a gluten challenge. However, patients respond with different magnitudes to the same gluten challenge. This is a problem that a group of researchers looked at recently, in a study of 19 well‐treated celiac patients.

    The research team included Jorunn Stamnaes; Daniel Stray; Maria Stensland; Vikas K. Sarna; Tuula A. Nyman; Knut E. A. Lundin; and Ludvig M. Sollid. They are variously affiliated with the K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; the Department of Immunology, University of Oslo and Oslo University Hospital‐Rikshospitalet, Oslo, Norway; and the Department of Gastroenterology, Oslo University Hospital‐Ullevål, Oslo, Norway. 
     
    In the study patients, proteome analysis of total tissue, or isolated epithelial cell compartment from formalin‐fixed paraffin embedded biopsies, collected before and after 14‐day gluten challenge, shows that patients with strong mucosal response to gluten challenge have signs of ongoing tissue inflammation prior to the gluten challenge. 

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    This low‐level tissue inflammation at baseline is mirrored by increased gluten specific CD4+ T‐cells in the gut, and a low‐level blood inflammatory profile. 

    This study shows that even well‐treated celiac disease commonly features ongoing low‐grade inflammation and anti-gluten immunity in the gut mucosa, and that histology assessment alone is not a good measure of full recovery and gut mucosal healing in celiac patients. 

    The findings raise a concern that even a vigilant gluten‐free diet might not be enough to curb gut inflammation in all celiac disease patients.

    Read more at Wiley Online Library

    Edited by Scott Adams



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    AnonyousCda

    When in doubt try out Berberine supplement 1500 mg a day for 3 weeks. 

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    Guest Randall

    Posted

    On 3/15/2021 at 4:18 PM, Guest diagnosed with problems said:

    I was diagnosed in 2010 and continue to have diarrhea and now constipation issues no matter that I adhere to a strict diet and have had proof of villa renewed.  Why some people continue to have T cell activity could be due to other autoimmune diseases? I also have RA. 

    You might want to start looking at other common things that Celiac sufferers have problems with like dairy. I have problems with: dairy, sorghum flour (causes a laxative effect within 20 minutes with me), and eggs.

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    AnnMarie RHWC
    On 3/10/2021 at 7:06 PM, trents said:

    One take away from this is we may need to more often give the benefit of the doubt to those who post on the forum and are adamant about being gluten free.

    We have also had a large number of people post on the forum recently who have new onset of celiac symptoms after being largely asymptomatic for years once going gluten free. The article makes me wonder if there is more going on than just having develop intolerances/allergies to non gluten foods.

    Healing from Celiac is different for each person. The degree to which the small intestine is damaged and the amount of inflammation that each person has varies.  And to your point, there could be additional allergies that mimic similar symptoms as being exposed to gluten.  Dairy is a case-in-point as many Celiacs suffer with symptoms due to dairy.  Also, something to consider and perhaps be aware of...gluten is a lectin.  If you experience symptoms from eating other lectins you could perhaps uncover another culprit to what seems to be a gluten exposure.  Healing the gut lining so that you can repair the villi and also improve absorption of nutrients as well as reducing inflammation is a great start to healing.  Doing a 30-food elimination with a slow reintroduction could uncover foods that cause distress.  Considering probiotic and prebiotics can assist in healing gut tissue.  Reducing stress.  There are many things to consider to uncover phantom symptoms or molecular mimicry that cause continued distress even after a gluten-free diet.

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    Hulmey

    What's the story of eating meat products and by products from animals that eat gluten, e.g. eggs from chickens with gluten in their diet, milk from cows that eat wheat grain, etc. I have read in a few places that tiny fragments of gluten are passed on in these products. There is research evidence showing mums who eat gluten have gluten present in their milk when they feed their babies. Are we going 'up stream' enough yet with the hidden glutens creeping into the diets of coeliacs that may be retaining these residual levels of inflammation?

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    Scott Adams

    I've not seen any evidence that eggs, milk or meat from animals that are fed gluten is not gluten-free:

     

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    trents
    25 minutes ago, Hulmey said:

    What's the story of eating meat products and by products from animals that eat gluten, e.g. eggs from chickens with gluten in their diet, milk from cows that eat wheat grain, etc. I have read in a few places that tiny fragments of gluten are passed on in these products. There is research evidence showing mums who eat gluten have gluten present in their milk when they feed their babies. Are we going 'up stream' enough yet with the hidden glutens creeping into the diets of coeliacs that may be retaining these residual levels of inflammation?

    Good question and one I remember coming up before on the forum. I'm not aware of any research suggesting that we can get glutened from eating animal products coming from animals who were fed gluten. Having said that, we used to confidently claim that distilled liquors were free of gluten but anecdotal experiences are challenging that assertion. We are also seeing a lot of anecdotal evidence that people can be glutened transdermally from health and beauty aid products. And it may be one of those things that depends on the sensitivity level of the individual celiac.

    Edited by trents
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    Guest Lili Krins

    Posted

    On 3/16/2021 at 8:18 AM, Guest diagnosed with problems said:

    I was diagnosed in 2010 and continue to have diarrhea and now constipation issues no matter that I adhere to a strict diet and have had proof of villa renewed.  Why some people continue to have T cell activity could be due to other autoimmune diseases? I also have RA. 

    Yes, same here. I have been looking at information which suggests that its not limited to the 3-4 main listed glutens but the other types found in all grains. You could be sensitive to corn, buckwheat etc as well. Its so hard to find out more, not much research out there.

    I now have Osteoporosis, so the damage seems to continue.🙄

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    trents
    3 minutes ago, Guest Lili Krins said:

    Yes, same here. I have been looking at information which suggests that its not limited to the 3-4 main listed glutens but the other types found in all grains. You could be sensitive to corn, buckwheat etc as well. Its so hard to find out more, not much research out there.

    I now have Osteoporosis, so the damage seems to continue.🙄

    Buckwheat is not a cereal grain. It is the seeds from plants in the same family as rhubarb. Totally different than wheat, barley, rye, rice, corn, etc.

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    TrishaW
    On 3/10/2021 at 6:06 PM, trents said:

    One take away from this is we may need to more often give the benefit of the doubt to those who post on the forum and are adamant about being gluten free.

    We have also had a large number of people post on the forum recently who have new onset of celiac symptoms after being largely asymptomatic for years once going gluten free. The article makes me wonder if there is more going on than just having develop intolerances/allergies to non gluten foods.

    I wonder if more people are reacting to the glyphosate in whatever gluten-free products they are eating. That is the case with me. I am completely symptom free if I eat organic. 

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    plumbago
    29 minutes ago, TrishaW said:

    I wonder if more people are reacting to the glyphosate in whatever gluten-free products they are eating. That is the case with me. I am completely symptom free if I eat organic. 

    I started hearing about that about 6 or so years ago. I don't know what to make of it.

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    Guest JulieEMM

    Posted

    On 3/16/2021 at 8:18 AM, Guest diagnosed with problems said:

    I was diagnosed in 2010 and continue to have diarrhea and now constipation issues no matter that I adhere to a strict diet and have had proof of villa renewed.  Why some people continue to have T cell activity could be due to other autoimmune diseases? I also have RA. 

    I agree.  I'm similar.  Strictly gluten-free 5 yrs.  Yet severe constipation only relieved by drinking 2 sachets movicol daily.  Still damaged villi, can't absorb necessary amounts of vit & minerals.  Take Iron for anemia, tri-monthly B12 injections, fibromyalgia syndrome with horrendous peripheral neuropathy. And unrelenting IBS even though on a Low FODMAP diet too.  Recently diagnosed Lupus arthritis, so lovely lumpy knuckles and toes, Skin rashes.  On meds for all, yet still have abnormal inflammatory markers with now suspected Inverted Psoriatic Arthritis (I'd never heard of it). 

    Will it ever end?!?!  :(

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    sc'Que?

    No meds nor supplements here.  I might cross the line to supplements eventually, but I have no desire to participate in the pharmaceutical industry's farce.  (I also think we try to live longer than our planet can realistically sustain.) So once I get to that point, it's time to find the new Dr.Kavorkian.  

     

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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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