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  • Scott Adams
    Scott Adams

    A Gluten-Free Diet May Not Stop Gut Inflammation for all Celiac Disease Patients

    Reviewed and edited by a celiac disease expert.

    New study shows that a gluten‐free diet may not be enough to curb gut inflammation in all celiac disease patients.

    A Gluten-Free Diet May Not Stop Gut Inflammation for all Celiac Disease Patients - Image: CC BY 2.0--Güel - Centro de Wellness Murcia
    Caption: Image: CC BY 2.0--Güel - Centro de Wellness Murcia

    Celiac.com 03/08/2021 - When people with celiac disease eat gluten, it triggers adaptive immune cells, which cause damage to the lining of the small intestine. Doctors gauge the severity of celiac disease through histological assessment of the intestinal damage via intestinal biopsy. To confirm diagnosis and to test drug efficacy in clinical trials, doctors rely on a gluten challenge. However, patients respond with different magnitudes to the same gluten challenge. This is a problem that a group of researchers looked at recently, in a study of 19 well‐treated celiac patients.

    The research team included Jorunn Stamnaes; Daniel Stray; Maria Stensland; Vikas K. Sarna; Tuula A. Nyman; Knut E. A. Lundin; and Ludvig M. Sollid. They are variously affiliated with the K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway; the Department of Immunology, University of Oslo and Oslo University Hospital‐Rikshospitalet, Oslo, Norway; and the Department of Gastroenterology, Oslo University Hospital‐Ullevål, Oslo, Norway. 
     
    In the study patients, proteome analysis of total tissue, or isolated epithelial cell compartment from formalin‐fixed paraffin embedded biopsies, collected before and after 14‐day gluten challenge, shows that patients with strong mucosal response to gluten challenge have signs of ongoing tissue inflammation prior to the gluten challenge. 

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    This low‐level tissue inflammation at baseline is mirrored by increased gluten specific CD4+ T‐cells in the gut, and a low‐level blood inflammatory profile. 

    This study shows that even well‐treated celiac disease commonly features ongoing low‐grade inflammation and anti-gluten immunity in the gut mucosa, and that histology assessment alone is not a good measure of full recovery and gut mucosal healing in celiac patients. 

    The findings raise a concern that even a vigilant gluten‐free diet might not be enough to curb gut inflammation in all celiac disease patients.

    Read more at Wiley Online Library

    Edited by Scott Adams



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    Wheatwacked
    On 3/29/2021 at 8:18 PM, Monica2222 said:

    And how did u correct ur zinc levels 

    Oatmeal (3 mg/100g), hard Cheese(3mg/100g), Beef(4mg/100g), Flaxseed(4mg/100g(, Zinc Gluconate lozenges (13.3 per lozenge). peanuts(6mg/100g), Geritol tablets(13.3 per dose). RDA is 11mg/day, upper limit is 40mg/day.

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    Posterboy
    On 3/22/2021 at 3:33 PM, Monica2222 said:

    what’s the reason for vit deficiency after few years of gluten-free diet. My daughter is celiac. Till one year before, her all vit, micronutrients were under normal range despite her being not regular for her vitamins. In her latest blood work, zin & vit D are low. I am not very sure if it’s because of inflammation in the gut due to gluten exposure. If so, why are other vits & micronutrient & celiac markers r ok and same like last year report. And even if it’s because of intestinal inflammation due to cross contamination or accidental exposure of gluten, which she had in past too( she doesn’t have strong symptoms after exposure) why this time, only zinc & vit D is low. Or it could be due to diet low in zinc. She is having premature gray hair & hair fall issue. Would appreciate your understanding in this matter. Thanks. Monica 

     

    On 3/29/2021 at 7:27 PM, Monica2222 said:

    Her B3 level is good too

     

    On 3/29/2021 at 7:18 PM, Monica2222 said:

    And how did u correct ur zinc levels

    Monica,

    Go back and read this blog post on Zinc and IBS started by Blue Sky.

    https://www.celiac.com/blogs/entry/2747-zinc-magnesium-and-selenium-in-ibs/ 

    Taking Zinc lozenges is a good way to catch up on Zinc.

    They will become metallic tasting in your daughters mouth or yours if you get too much Zinc in your system.

    IF your daughter is low in Zinc....she is low in Niacin aka Vitamin B3 already.

    Niacin is important in the production of stomach acid and we get low in our minerals like Magnesium, Zinc and Iron when we get low in Stomach acid to name a few.

    Also Niacin helps absorb Zinc in the intestine's so she got low in Niacin FIRST then got low in Zinc because she was low in Vitamin B3 already.

    B-Vitamins being water soluble get low quickly in response to stress.

    Stress kills us....we all know that right....well it maims you first!

    And the first nutrients you get low in are your water soluble B-Vitamins.

    Here is the research how Niacin effects Zinc levels in the body.

    Entitled "Effect of nicotinic acid (aka Vitamin B3 or Niacin) on zinc and iron metabolism"

    https://pubmed.ncbi.nlm.nih.gov/9353874/

    quoting form the above research

    "When mice were fed with nicotinic acid-deficient, -adequate and -excess synthetic diets for four weeks it was observed that, in comparison with the nicotinic acid-deficient diet, percent zinc absorption, intestinal zinc, percent haeomoglobin and liver iron increased significantly under nicotinic acid-adequate and -excess conditions. The results obtained suggested that nicotinic acid, in addition to its known effect on growth and metabolism, may be playing an (Niacin plays) an important role in enhancing zinc and iron utilization."

      And why your daughter has gotten low in Zinc....

    The blog post on Zinc, Magnesium, and IBS explains this in more detail.

    When one gets low in stomach acid it is inevitable that some one will become low in their minerals! Because their stomach acid is no longer strong enough to absorb them.

    I wrote this Posterboy blog post that explains how and why low stomach acid can mimic NCGS and/or Celiac symptom's if you think it will help you too read it.

    https://www.celiac.com/blogs/entry/2106-is-ncgs-andor-celiac-disease-really-low-stomach-acid-misdiagnosed/

    I have had to reduce my time to focus on other things in life....but I wanted to try and help you and your daughter one more time......because I have been your daughter!

    And there is hope!  More and stronger stomach acid means more of your/her Minerals will be absorbed.

    I hope this is helpful but it is not medical advice.

    Posterboy, 

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    Wheatwacked
    On 3/22/2021 at 4:33 PM, Monica2222 said:

    Or it could be due to diet low in zinc.

    Zinc - Health Professional Fact Sheet (nih.gov): "red meat and poultry provide the majority of zinc in the American diet...Phytates—which are present in whole-grain breads, cereals, legumes, and other foods—bind zinc and inhibit its absorption...When the investigators considered intakes from both food and dietary supplements, they found that 20%–25% of older adults still had inadequate zinc intakes"  .Open Original Shared Link

    The relationship of serum vitamin D and Zinc in a nationally representative sample of Iranian children and adolescents: The CASPIAN-III study (nih.gov)Conclusion: We found significant associations between low serum concentrations of zinc and 25(OH) D. Food fortification or mineral supplementation should be considered in future health programs. Open Original Shared Link

    Keep a quantitative food log for a day or two. There are websites that you can use to calculate her daily intake. 

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    Wheatwacked
    On 3/22/2021 at 4:33 PM, Monica2222 said:

    Or it could be due to diet low in zinc.

    "The mean Zn level was significantly lower in the hypovitaminosis D group than in controls." Open Original Shared Link.

     

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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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