ActoGeniX Is Progressing Toward Celiac Disease Treatment

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
Record is Archived
This article is now archived and is closed to further replies.
By Roy Jamron

April 20, 2008
By Roy Jamron • April 20, 2008

ActoGeniX Is Progressing Toward Celiac Disease Treatment

Followers 0
Reviewed and edited by a celiac disease expert.

Celiac.com 04/20/2008 - Open Original Shared Link is a recently formed Belgian company specializing in the development and use of genetically altered probiotic Lactococcus lactis bacteria designed to secrete and deliver therapeutic peptides and proteins to treat gastrointestinal disorders. Their product is called ActoBiotics™. Celiac disease is among the disorders ActoGeniX is currently investigating. Research has already shown efficacy in a celiac disease model where ActoBiotics™ continuously secrete small segments of gluten peptides to induce tolerance to gluten. Further research and trials are in the pipeline.

Shortly after the release of a recent paper by Italian researchers demonstrating that a peptide from durum wheat is able to completely suppress the immune response to gluten in a culture of celiac disease intestinal T cells (see Open Original Shared Link ), I contacted ActoGeniX to suggest they work with the Italian researchers to create an ActoBiotic™ designed to continuously secrete the durum wheat peptide as a therapy for celiac disease. ActoGeniX replied and was very interested in the durum wheat peptide, indicating it was possible for them to produce an ActoBiotic™ to secrete the durum wheat peptide and they would contact the Italian group. I also attempted to contact the Italian researchers to inform them about ActoGeniX, but they did not reply. I strongly believe that a collaboration between these two groups would result in the speediest and most successful development of a treatment which could effectively "cure" celiac disease through continuous secretion of the durum wheat peptide by genetically modified probiotic bacteria in the gut.

Celiac.com Sponsor (A12):
ActoGeniX has recently totally revised their website which is now much more informative and includes short videos discussing ActoBiotics™ as well as a short video presentation of their celiac disease research. More about this article can be found on their website at Open Original Shared Link.

Technical information describing their product and initial research and development in detail is presented in the following patent application: Open Original Shared Link.
actogenix

celiac

celiac disease

disease

progressing

toward

treatment
Share
https://www.celiac.com/celiac-disease/actogenix-is-progressing-toward-celiac-disease-treatment-r1253/
Followers 0
Go to articles
User Feedback
- 2 Comments
Recommended Comments

Guest Ricardo Ferreira

Posted May 1, 2008

Share this comment

LetÂ´s hope a treatment is available in a near future.

Link to comment

Share on other sites

Guest L.A. Sal

Posted May 13, 2008

Share this comment

I sure hope there is a cure in the near future, but there's one thing that doesn't make sense:

I have read before about the benefits of probiotics for those of us with celiac, but the use of durum wheat of all things? That is difficult to get my head around, given that we can't have regular pasta, can't even have regular pasta touch gluten-free pasta.

Link to comment

Share on other sites

This is now closed for further comments
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Roy S. Jamron holds a B.S. in Physics from the University of Michigan and an M.S. in Engineering Applied Science from the University of California at Davis, and independently investigates the latest research on celiac disease and related disorders.
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Recovery from Celiac Disease - The New England Journal of Medicine
Celiac.com 03/19/2002 - The following excerpts were taken from The New England Journal of Medicines January 17, 2002 (Vol. 346, No. 30) article on recovery from celiac disease:
In addition to a gluten-free diet, all patients with newly diagnosed celiac sprue who have clinically evident malabsorption should initially receive a multi-vitamin preparation and appropriate supplements to correct any iron or folate deficiency. Patients with steatorrhea, hypocalcemia, or osteopenic bone disease should receive oral calcium and vitamin D supplementation.
Approximately 70 percent of patients have symptomatic improvement within two weeks after starting a gluten-free diet. The speed and eventual degree of histologic improvement are unpredictable but invariably lag behind the clinical...

Read Full Article...

0 comments

19,233 views
Improved Protocol Found for the Diagnosis of Celiac Disease
Am J Gastroenterol. 2002;97(11):2702-2704, 2785-2790
Celiac.com 04/30/2003 - The results of a population-based study published in the November 2002 edition of the American Journal of Gastroenterology indicate that it is time to change celiac disease screening methods. Karoly Horvath, MD, PhD, from the University of Maryland School of Medicine in Baltimore, and Ivor D. Hill, MD, from Wake Forest University School of Medicine in Winston-Salem, North Carolina, found that testing first for tissue transglutaminase (tTG) antibodies followed by endomysial antibodies may eliminate the need to screen using antigliadin IgA.
Using a community-based population the researchers screened the blood of 1,000 consecutive subjects (age 16 to 71 years, 497 women) using the three tier classic...

Read Full Article...

0 comments

7,230 views
Antacids May Trigger Food Allergies
Celiac.com 03/16/2004 - According to Dr. Erika Jensen-Jarolim, professor of medicine and immunology at the University of Vienna, there may be a connection between the development of food allergies and the use of antacids. Dr. Jensen-Jarolim presented her teams preliminary findings at the World Allergy Congress on September 10, 2003. Individuals who take medications that reduce or neutralize the acidity in the stomach may be at a higher risk of developing food allergies, possibly caused by normally harmless food proteins passing in tact through the digestive system. Normally acid and pepsin break down food proteins before they pass into the digestive tract, and if Dr. Jensen-Jarolim is correct, interrupting this process could cause serious, lifelong consequences. Dozens of over...

Read Full Article...

0 comments

13,948 views
In Vitro Gliadin Challenge Offers Accurate Diagnosis of Difficult Celiac Disease Cases
Celiac.com 10/24/2012 - Doctors can face challenges when attempting to diagnose celiac disease in patients who have already begun a gluten-free diet, and/or when the results of tests are inconsistent.
To better understand this problem, a group of researchers set out to assess the benefits of an in vitro gliadin challenge.
The research team included Raffaella Tortora, MD, Ilaria Russo, PhD, Giovanni D. De Palma, MD, Alessandro Luciani, PhD, Antonio Rispo, MD, Fabiana Zingone, MD, Paola Iovino, MD, Pietro Capone, MD and Carolina Ciacci, MD.
The study cohort included 57 patients without celiac disease, 166 patients with untreated celiac disease, 55 patients with celiac disease on a gluten-free diet, and 59 patients with challenging diagnosis.
The team provided all patients...

Read Full Article...

4 comments

13,666 views
Recent Activity
1. 3 hours ago - knitty kitty replied to CeliacChica's topic in Related Issues & Disorders
  30
  
  Muscle Twitching
  
  Hello, I'd have been here sooner, but I got tangled up in yarn... Restless leg syndrome (RLS) I've had. It's often associated with iron deficiency and B12 deficiency, but can also show up with any deficiencies in Vitamin C, copper, Vitamin D, and Thiamine, Pyridoxine, and magnesium. B12, Thiamine, and Pyridoxine will also help with peripheral neuropathy...
2. 8 hours ago - Jtestani posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  0
  
  Help with results please. As I have a appt after the New Year.
  
  My question is .. my test results Ttg (IgA 1.7 u/ml & IgG 3:3 u/ml) both negative & DGP IGG 7.1025 negative but DGP IGA postive at 36.2007 U/ML. Am I showing a negative test result? any insight helps as I have to wait till new year for next Doctor’s appt. Thanks
3. Saturday at 11:15 PM - StaciField replied to StaciField's topic in Related Issues & Disorders
  8
  
  My bone structure is disintegrating and I’m having to have my teeth removed
  
  There’s a Cosco in Auckland in New Zealand. It’s a bit away from where I live but it’s worth the travel for me. Very appreciative of your advice.
4. Saturday at 10:49 PM - Wheatwacked replied to More2Learn's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  2
  
  Celiac Maybe a Possibility?
  
  It seems you have proven that you cannot eat gluten. You've done what your doctors have not been able to do in 40 years. That's your low vitamin D, a common symptom with Celiac Disease. Zinc is also a common defiency. Its an antiviral. that's why zinc gluconate lozenges work against airborne viruses. Vitamin D and the Immune System+ ...
5. Saturday at 08:47 PM - John.B posted a topic in Gluten-Free Foods, Products, Shopping & Medications
  0
  
  Allergy Meds
  
  Hello, Target recently changed their branding on the Up & Up Loratadine and no long have it labeled gluten free. I've not been able to find any meds labeled gluten free for allergies. Some lists showed them but the the packaging isn't labeled. Wondering if anyone knows of or has a list that would be safe for Celiac kiddos.