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  • Jefferson Adams
    Jefferson Adams

    Are Celiac Disease Drug Treatments Just a Pipe Dream?

    Reviewed and edited by a celiac disease expert.

    We're running low on viable drug candidates for treating celiac disease outside of a gluten-free diet.

    Are Celiac Disease Drug Treatments Just a Pipe Dream? - Art For art's sake. Image: CC BY-SA 2.0--Thomas Berg
    Caption: Art For art's sake. Image: CC BY-SA 2.0--Thomas Berg

    Celiac.com 09/21/2022 - The dream of creating a safe, effective drug that can help people with celiac disease to tolerate small amounts, or perhaps even large amounts, of gluten. Until its recent failure, 9 Meters' larazotide was the only celiac drug in Phase 3 clinical trials. The recent discontinuation of larazotide, based on disappointing interim results, highlights the unmet need for effective alternatives to a gluten-free diet for treating celiac disease. 

    Larazotide's failure also opens the doors for current and future Phase 1 and Phase 2 celiac therapies to be first-to-market. It also highlights the lack of a good lineup of potential new drugs. The reality is that, with the collapse of several once promising candidates, the bench for viable alternative celiac disease treatments is shallow, at best.

    Current Celiac Disease Pipeline Therapies Include:

    • Latiglutenase (ImmunogenX)
    • PRV-015 (Provention Bio, Inc. with Amgen)
    • TAK-101 (Takeda Pharmaceuticals)
    • ZED-1227 (ZEDIRA GmbH)
    • KAN-101 (Anokion SA)

    Celiac.com Sponsor (A12):
    In an effort to assess the current and future alternatives for treating celiac disease without a gluten-free diet, data marketing company Spherix recently interviewed one-hundred US gastroenterologists, and conducted eight qualitative interviews to compile a report on the issue.

    Spherix has issued a recent report on the form gastroenterologists engaged in a thorough review of these pipeline product descriptions (based on publicly available clinical information for each product). The report assesses celiac diagnostic and treatment trends emerging, as well as physician reactions to potential therapies in the pipeline.

    The 2022 report reveals a greater sense of urgency from gastroenterologists versus the 2021 report. Indeed, the number of respondents in the 2022 survey who say that their celiac patient load has increased in the past year, is up by 60% over 2021.

    Read more at PRNewswire.com
     

     



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    Dina Wright
    5 hours ago, sc'Que? said:

    It is a my profession as a craft bartender to elevate the drinking experience--not to dumb it down!  American macro-pilsners (on which most gluten-free beers are based) are not attempting to mimic the quality of pre-Prohibition beers: they're simply trying to make a buck from people who forgot what beer is supposed to taste like... and Celiacs are a super-convenient target!   

    I take every opportunity I can to remind Celiacs that the beer they're being peddled is not the quality it should be!  If the Chartier-Glutenberg (sub-)label still exists, track down the shiso saison.  It is/was a textbook saison on the palate--packed with flavor to stand up to most American/French/Mediterranean summer cuisine--but with all gluten-free ingredients on a dedicated gluten-free line.  Honsetly, I haven't enjoyed a gluten-free beer since it disappeared from my market. 

    Open Original Shared Link

    I cannot find the Vagabond beer made by Brew Dog in Texas. The brewery told us that it is brewed gluten free. I researched its credibility but haven’t seen anything saying that it’s not. I’ve read recently that’s it’s brewed to be gluten free and then sent off to another brewery to further remove any gluten that would put it far below the 20ppm to make it gluten free. 
    We’re all trying to get answers regarding gluten free drinks/food, no need for cattiness. 
    Like I said in my original post, it works for me (Corona Premier) and so did the Vagabond I found in Scotland made by Brew Dog. In my opinion, Red Bridge doesn’t taste at all like beer🤷🏼‍♀️

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    Guest David
    On 9/26/2022 at 5:26 PM, trents said:

    I think this excerpt from the article is very important: "The 2022 report reveals a greater sense of urgency from gastroenterologists versus the 2021 report. Indeed, the number of respondents in the 2022 survey who say that their celiac patient load has increased in the past year, is up by 60% over 2021."

    60% increase in celiac patient load in one year! That could bring action on several fronts.

    (1) It doesn't say the patient load increased by 60%, it says that "of the respondents", 60% said their cases increased (perhaps this increase is only by 5%-10%) relative to the prior year. (2) Doctor visits were down during the COVID, so it may reflect more doctor visits in 2022 vs 2021, rather than a spike in prevalence.

    That said, one could speculate that COVID might have been a catalyst for Celiac to develop in some people.

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    trents

    You are correct, David. Thanks for catching that.

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    sc'Que?
    On 10/1/2022 at 9:27 AM, Dina Wright said:

    I cannot find the Vagabond beer made by Brew Dog in Texas. The brewery told us that it is brewed gluten free. I researched its credibility but haven’t seen anything saying that it’s not. I’ve read recently that’s it’s brewed to be gluten free and then sent off to another brewery to further remove any gluten that would put it far below the 20ppm to make it gluten free. 
    We’re all trying to get answers regarding gluten free drinks/food, no need for cattiness. 
    Like I said in my original post, it works for me (Corona Premier) and so did the Vagabond I found in Scotland made by Brew Dog. In my opinion, Red Bridge doesn’t taste at all like beer🤷🏼‍♀️

    Cattiness?  No, more like trying to remind everyone that "Budweiser" (as a concept) does not equate to "beer" as a category.  If there are 150 styles of beer, pale pilsner represents less than 1%. And the companies that produce gluten-free beer/s prey on the fact that most people don't realise that.  

    There are other styles of beer that are more conducive to being made gluten-free.  Why aren't we making them? 

    Also, re: "[t]he brewery told us that it is brewed gluten free. I researched its credibility but haven’t seen anything saying that it’s not. I’ve read recently that’s it’s brewed to be gluten free and then sent off to another brewery to further remove any gluten that would put it far below the 20ppm to make it gluten free."  If it's brewed gluten-free, there is no reason for it to be sent somewhere else to have gluten removed.  Don't be duped.

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    Guest Guest123

    Posted

    If you're close to Pittsburgh, try this. They also take online orders. www.aurochsbrewing.com

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    sc'Que?
    20 hours ago, Guest Guest123 said:

    If you're close to Pittsburgh, try this. They also take online orders. www.aurochsbrewing.com

    Being just 3 hrs away, I've heard good things. But I've not had the opportunity to to travel since pre-CoViD.  @Guest123, thx for the reminder! 

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    Decogirl

    Hi all!

    Here is a dilemma-i was diagnosed with celiac disease via gold standard biopsy of small intestine, and endoscopy.  So after many years of “accidentally” being glutened by “gluten free “ products, I follow a very strict gluten-free diet-and eat foods that are ONLY CERTIFIED GLUTEN FREE.  GOING OUT TO DINNER IS ALWAYS A MAJOR CHALLENGE.  There are only a few near my home that I trust.

    So here is my dilemma….I drank one drink containing Bacardi Superior white rum, with Silk “Nogg”. Like real egg nogg.  It says Gluten free right on the label, in 3 different places., and I drink regular Silk almond milk., so I felt very safe in drinking this.  Within an hour of drinking this, I felt like throwing up….then I had loose stools and stomach cramps for 2 hours!  4 hours later I had to go out at 4:00 AM to get some Imodium.  I tested both the Silk “Nogg” and the Bacardi…with my Nima Sensor-.the Silk “Nogg”  tested “gluten found” in my Nima Sensor.  The Bacardi tested negative.  The Silk Nogg has “gluten free” in 3 different places, INCLUDING the front.  I am so pissed! Not only did it ruin my delicious steak dinner my husband prepared, but now, at 4:47 am, feeling like a wet noodle, I won’t be able to work tomorrow.  This is simply unacceptable!  These companies need to be held accountable for their “gluten free” claims. 

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    Scott Adams

    So how is that relevant to this article? Perhaps post a new thread in our forum on your Silk experience?

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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