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  • Jefferson Adams
    Jefferson Adams

    Atopic Dermatitis Increases Risk for Other Autoimmune Conditions

    Reviewed and edited by a celiac disease expert.

    What's the connection between atopic dermatitis and immune dysregulation?

    Atopic Dermatitis Increases Risk for Other Autoimmune Conditions - Shallow, then halo. Image: CC BY-SA 2.0--Thomas Berg
    Caption: Shallow, then halo. Image: CC BY-SA 2.0--Thomas Berg


    Celiac.com 12/12/2022 - Atopic dermatitis is associated with immune dysregulation, but epidemiological data on the pattern of autoimmune comorbidity in people with atopic dermatitis are limited.

    A team of researchers recently set out to determine the risk of autoimmune conditions in people newly diagnosed with atopic dermatitis.

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    The research team included Simon de Lusignan, MD; Helen Alexander, BSc, MBBS; Conor Broderick, MB, BCh, BAO, MSc; Andrew McGovern, MD; Claire Feeney, PhD; Carsten Flohr, PhD. They are variously affiliated with theNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom; the Royal College of General Practitioners Research and Surveillance Centre, London, United Kingdom; the Unit for Population-Based Dermatology Research, St John’s Institute of Dermatology, Guy’s & St Thomas’ NHS Foundation Trust and King’s College London, London, United Kingdom; the Momentum Data, Pendragon House, St Albans, United Kingdom; and with Pfizer Ltd, Tadworth, United Kingdom.

    A Retrospective Cohort Analysis

    The team used the the UK-based Oxford–Royal College of General Practitioners Research and Surveillance Centre primary care database to conduct a retrospective cohort analysis that covered the period from January 2009 to December 2018. 

    They compared baseline rates and incidents after diagnosis of autoimmune conditions in nearly 175,000 children and adults with new-onset atopic dermatitis, and nearly 700,000 control subjects, matched for age, sex, and general practitioner practice. 

    Outcomes were a composite of any autoimmune condition, including Crohn disease, ulcerative colitis, celiac disease, pernicious anemia, type 1 diabetes, autoimmune hypothyroidism, Graves disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, Sjögren syndrome, vitiligo, alopecia areata, and multiple sclerosis, and each individual autoimmune condition.

    Their Findings

    The team found that people diagnosed with atopic dermatitis were more likely to have an existing autoimmune condition, compared to control subjects. 

    Once the team eliminated patients with preexisting autoimmune disease, they found a connection between atopic dermatitis and cases of new-onset autoimmune disease. Patients with more severe atopic dermatitis faced a greater risk than those with moderate or mild atopic dermatitis. 

    People with atopic dermatitis also faced a significantly higher risk for psoriatic arthritis, Sjögren syndrome, Crohn disease, vitiligo, alopecia areata, pernicious anemia, ulcerative colitis, rheumatoid arthritis, and hypothyroidism, but not for other autoimmune conditions.

    Conclusions

    From their results, the team concludes that people with atopic dermatitis, especially those with severe atopic dermatitis, face significantly higher risk for developing numerous other autoimmune conditions.

    Stay tuned for more on this and related stories. 

    Read more in: Allergy and Clinical Immunology
     



    User Feedback

    Recommended Comments

    Posterboy

    To All,

    Niacin has been shown to treat Atopic Dermatitis.

    See this research about it....

    Entitled "Pellagra occurring in a patient with atopic dermatitis and food allergy"

    https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1468-3083.2006.01871.x

    From the right column bottom of above citation.......can't copy and paste it.....so I will type relevant part...

    Quoting

    "Oral Nicotinamide and a Vitamin B (complex) were commenced. Within a week their rash had resolved".

    Pretty convincing proof IMHO!

    This has been found to be true for Psorisas too!

    See this research entilted "Nicotinamide: a potential addition to the anti-psoriatic weaponry"

    https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.03-0002hyp?journalCode=fasebj&legid=fasebj%3B17%2F11%2F1377&related-urls=yes

    IN Short if you have skin involvement Niacinamide should be one of the first Vitamins you trial.......better yet take a B-Complex.....(Because you will be low in ALL your B-Vitamins) if you are low in Niacinamide.

    I wrote a Posterboy blog post about this......we have ONE Immune System with many faces.....like in Lupus.

    Just like Pellagra It has 3 Faces.....with the Skin Issues being the most visual and recognizable by doctor's today......but they are so "Myopic" in their Vision......they ONLY see it (Pellagra) if you are Homeless or an Acoholic.....or instead you get Lupus or Sjorgens Disease etc.....or Atopic Dermatitis or Psorsias etc.....and you immnue system never heals.....

    Take (learn form LUPUS)......Niacin helps it too!

    Or it goes misdiagnsoed as many other Skin issues! Yes even as DH in some cases......

    See this reasearch about it entitled "NICOTINICACID (aka Niacin) THERAPYOFDERMATITISHERPETIFORMIS"

    I didn't capitalize it (title) that is how they wrote in the original research.

    https://www.jidonline.org/article/S0022-202X(15)50482-X/pdf

    That are other things I could quote from the article but I want you to read it for youself....and the formatting when you copy doesn't come over just right......so I have to edit it.....so I just choose this quick summary because it is instructive to you/me/us.

    But this says it all to me!

    Quoting

    "Niacin was prescribed in small doses, later increased to 0.1Gm  four times daily.  When
    seen 3 weeks later the skin showed complete remission of active lesions and she was free
    from itching."

    I hope this is helpful but it is not medical advice.

    As always, “Consider what I say; and the Lord give thee understanding in all things” this included.

    2 Timothy 2:7 

    Posterboy by the grace of God,

     

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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