Can Probiotics Help Prevent Celiac Disease and IBD in Pediatrics?

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
By Jefferson Adams

December 28, 2018
By Jefferson Adams • December 28, 2018

Can Probiotics Help Prevent Celiac Disease and IBD in Pediatrics?

Followers 3
Reviewed and edited by a celiac disease expert.

Beyond a few teaser studies, we don’t know enough about whether the individual microbiome to celiac disease and inflammatory bowel disease, says top celiac disease researcher Alessio Fasano.

Caption: Image: CC--Honza Soukup

Celiac.com 12/28/2018 - Beyond a few teaser studies, we don’t know enough about whether the individual micro-biome might play a role in the development of celiac disease and inflammatory bowel disease.

Top celiac researcher Alessio Fasano, together with colleague G. Serena, recently presented an overview of current knowledge regarding the contribution of the individual micro-biome to celiac disease and inflammatory bowel disease. Their discussion includes a particular focus on how probiotics may be used as potential preventive therapy for CIDs.

Celiac.com Sponsor (A12):
They are both affiliated with the Mucosal Immunology and Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children - Harvard Medical School, Boston, MA, USA.

As part of their presentation, they write that, globally, cases of chronic inflammatory diseases (CIDs) are undergoing a steep rise. This rise, together with limited effective strategies for slowing these disease explosions demands deeper knowledge of their physical mechanisms in order to reduce the adverse effects of the diseases on children.

Several cross-sectional studies have shown a connection between intestinal microbial imbalance and active disease. Unfortunately, they note, these studies do not demonstrate any connection between changes in microflora as a factor in disease development, and so do not suggest any promising directions to explore for possible treatments.

Fasano and Serena say that additional studies are needed to show conclusively whether intestinal dysbiosis plays a part in triggering CIDs. Furthermore, given the complexity of the microflora interaction with the host, it is necessary to design a systems-level model of interactions between the host and the development of disease by integrating micro-biome, metagenomics, metatranscriptomics, and metabolomics with either clinical or environmental data.

In their overview, Fasano and Serena discuss the current knowledge regarding the contribution of the individual microbiome to celiac disease and inflammatory bowel disease. Their discussion includes a particular focus on how probiotics may be used as potential preventive therapy for CIDs.

The article includes a paywall, but you may find it at:
Adv Exp Med Biol. 2018 Dec 20. doi: 10.1007/5584_2018_317
celiac disease

ibd

inflammatory bowel disease

microbiome

microbiota

prevent

probiotics
Blue-Sky

1
Share
Followers 3
Go to articles
User Feedback
- 4 Comments
Recommended Comments

Elizabeth potter 2

Posted July 26, 2022

Share this comment

I have celiac disease and inflammatory bowel disease - I have extreme constipation and take xifaxan - I do not have colitis tho - finally after years of probiotics and antibiotics I’m much better

Blue-Sky and Scott Adams

2

Link to comment

Share on other sites

Suzzi5 0

Posted July 30, 2022

Share this comment

Does anyone with celiac disease use probiotics? Just started taking antibiotic and was wondering if it’s beneficial to take while I’m taking the antibiotic. Thanks.

Link to comment

Share on other sites

Scott Adams 1,859

Posted July 30, 2022

Share this comment

Many people with celiac disease do take probiotics to help them decrease symptoms.

Link to comment

Share on other sites

Wheatwacked 515

Posted August 4, 2022

Share this comment

Open Original Shared Link

41% of patients (254 of 624) in the XIFAXAN 550 mg group,

31% of TARGET 1 placebo group (98 of 314) and

32% of TARGET 2 placebo group (103 of 320) experienced adequate relief of IBS signs and symptoms.

Composite endpoint was defined as ≥30% decrease from baseline in abdominal pain

I don't see much difference between placebo and Xifaxan.

Antibiotics kill off the beneficial bugs in us as well as the bad, so anything to improve the environment in the gut would prove benificial. Home made dill pickles, fermented in salt and not sterilized helped me with lactose intolerance. NOT PICKLED with vinegar.

Commercial milk has a 5:1 omega 6 to 3 ratio. 100% Grass fed milk is 1:1 and Organic milk is 3:1. Omega 6 is proinflammatory.

Link to comment

Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!
Register a new account

Sign in

Already have an account? Sign in here.
Sign In Now
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

>VIEW ALL ARTICLES BY JEFFERSON ADAMS
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Diverse Gut Flora Hold Interest for Celiac Disease Researchers
Celiac.com 03/17/2014 - Researchers know a great deal about the function of human digestive proteases in gluten proteins, but they know very little about the role of intestinal microbes in metabolizing those proteins.
A team of researchers recently set out to examine the isolation and characterization of human gut bacteria involved in the metabolizing gluten proteins.
The researchers include Alberto Caminero, Alexandra R. Herrán, Esther Nistal, Jenifer Pérez-Andrés, Luis Vaquero, Santiago Vivas, José María G. Ruiz de Morales, Silvia M. Albillos, and Javier Casqueiro.
They are variously affiliated with the Instituto de Biología Molecular, Genómica y Proteómica (INBIOMIC), and the Instituto de Biomedicina (IBIOMED) at the Campus de Vegazana of the Universidad de León...

Read Full Article...

1 comment

7,975 views
What Role Do Infectious Mediators and Gut Microbes Play in Celiac Disease?
Celiac.com 04/13/2015 - Celiac disease is associated complications in the small bowel, but also with problems outside the GI tract. Celiac disease affects small bowel mucosal immunity via exposure to infectious agents; therefore, it is likely that patients with untreated celiac disease are more susceptible to infectious diseases. It is possible that sensitivity to gluten increases in patients with infectious diseases, and that infection may consequently trigger celiac disease in susceptible individuals.
A team of researchers recently conducted a review of medical literature to determine if infectious mediators may stimulate an immune reaction and act as a trigger factor for celiac disease in susceptible individuals. The research team included Mohammad Rostami-Nejad PhD, Sauid Ishaq FRCP...

Read Full Article...

0 comments

8,614 views
Why Your Microbiome is the Future of Celiac Disease Treatment
Celiac.com 12/25/2017 - In the very near future, your personal microbiome may be the key to creating a customized treatment for celiac disease.
That's because new advances in genome studies are promising to help create a customized, individual approach for treating numerous disorders, including celiac disease. Such individualized treatments may also help to reduce adverse events, and decrease health care costs.
So far, a similar approach for optimizing preventive and therapeutic approaches in cancer using human genome sequencing has proven successful.
Writing in the Mayo Clinic Proceedings, ad team of researches expounded on this approach. The research team included Purna C. Kashyap, Nicholas Chia, PhD, Heidi Nelson, MD, Eran Segal, PhD, and Eran Elinav, MD, PhD. They are variously...

Read Full Article...

3 comments

8,407 views
Can Early Life Gut Microbiota Predict Celiac Disease Development?
Celiac.com 04/16/2018 - A team of researchers recently set out to investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease onset in infants with family risk for the disease.
The research team included Marta Olivares, Alan W. Walker, Amalia Capilla, Alfonso Benítez-Páez, Francesc Palau, Julian Parkhill, Gemma Castillejo, and Yolanda Sanz. They are variously affiliated with the Microbial Ecology, Nutrition and Health Research Unit, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), C/Catedrático Agustín Escardin, Paterna, Valencia, Spain; the Gut Health Group, The Rowett Institute, University of Aberdeen, Aberdeen, UK; the Genetics and Molecular Medicine Unit, Institute of Biomedicine of Val...

Read Full Article...

0 comments

3,391 views
Recent Activity
1. 7 hours ago - Bltjr21 replied to MSawhill's topic in Related Issues & Disorders
  3
  Colitis
  
  I do. That’s actually what tipped my GI dr off to check for celiac. I was first, diagnosed with lymphocytic colitis through my colonoscopy. I immediately started a two month course of budesonide, and then had to labs done for celiac. When that came back positive, we did the endoscopy to confirm things.
  
  1
2. 7 hours ago - glucel replied to glucel's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
  15
  
  3 month retest
  
  Yes I forgot it is the green leafy. I just don't take drugs well. It wasn't just the inr but was also getting nose bleeds. Right now I have to figure out what I am going to do with the mri as discussed with rmj on this page and see how my weight goes. Need to get some info together before my next cardio visit so I can deal with a doc who claims celiac and...
3. 8 hours ago - glucel replied to glucel's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
  15
  
  3 month retest
  
  I was taking the non biological of folate and b12. Have since started methyl forms. Looking forward to some healing.
4. 8 hours ago - trents replied to glucel's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
  15
  
  3 month retest
  
  I have been on Coumadin for years because I have a genetic blood clotting disorder known as Factor 5 Leiden. I think it's mainly green leafy veggies that you have to worry about. They are the ones high in vitamin K. And if your are consistent in your consumption of them it your INR should level out. I get my INR checked every 6 weeks. Certain medications...
5. 8 hours ago - glucel replied to glucel's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
  15
  
  3 month retest
  
  I was on coumadin for a while after surgery and had a lot of trouble with vitamin k which pretty much curtailed how many veggies I could eat. The constant testing for vitamin k was expensive and a nuisance. I plan to ask doc if nsaid can be taken every other day instead of daily.