Can Probiotics Help Prevent Celiac Disease and IBD in Pediatrics?

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By Jefferson Adams

December 28, 2018
By Jefferson Adams • December 28, 2018

Can Probiotics Help Prevent Celiac Disease and IBD in Pediatrics?

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Reviewed and edited by a celiac disease expert.

Beyond a few teaser studies, we don’t know enough about whether the individual microbiome to celiac disease and inflammatory bowel disease, says top celiac disease researcher Alessio Fasano.

Caption: Image: CC--Honza Soukup

Celiac.com 12/28/2018 - Beyond a few teaser studies, we don’t know enough about whether the individual micro-biome might play a role in the development of celiac disease and inflammatory bowel disease.

Top celiac researcher Alessio Fasano, together with colleague G. Serena, recently presented an overview of current knowledge regarding the contribution of the individual micro-biome to celiac disease and inflammatory bowel disease. Their discussion includes a particular focus on how probiotics may be used as potential preventive therapy for CIDs.

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They are both affiliated with the Mucosal Immunology and Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children - Harvard Medical School, Boston, MA, USA.

As part of their presentation, they write that, globally, cases of chronic inflammatory diseases (CIDs) are undergoing a steep rise. This rise, together with limited effective strategies for slowing these disease explosions demands deeper knowledge of their physical mechanisms in order to reduce the adverse effects of the diseases on children.

Several cross-sectional studies have shown a connection between intestinal microbial imbalance and active disease. Unfortunately, they note, these studies do not demonstrate any connection between changes in microflora as a factor in disease development, and so do not suggest any promising directions to explore for possible treatments.

Fasano and Serena say that additional studies are needed to show conclusively whether intestinal dysbiosis plays a part in triggering CIDs. Furthermore, given the complexity of the microflora interaction with the host, it is necessary to design a systems-level model of interactions between the host and the development of disease by integrating micro-biome, metagenomics, metatranscriptomics, and metabolomics with either clinical or environmental data.

In their overview, Fasano and Serena discuss the current knowledge regarding the contribution of the individual microbiome to celiac disease and inflammatory bowel disease. Their discussion includes a particular focus on how probiotics may be used as potential preventive therapy for CIDs.

The article includes a paywall, but you may find it at:
Adv Exp Med Biol. 2018 Dec 20. doi: 10.1007/5584_2018_317
celiac disease

ibd

inflammatory bowel disease

microbiome

microbiota

prevent

probiotics
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Elizabeth potter 2

Posted July 26, 2022

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I have celiac disease and inflammatory bowel disease - I have extreme constipation and take xifaxan - I do not have colitis tho - finally after years of probiotics and antibiotics I’m much better

Scott Adams and Blue-Sky

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Suzzi5 0

Posted July 30, 2022

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Does anyone with celiac disease use probiotics? Just started taking antibiotic and was wondering if it’s beneficial to take while I’m taking the antibiotic. Thanks.

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Scott Adams 1,911

Posted July 30, 2022

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Many people with celiac disease do take probiotics to help them decrease symptoms.

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Wheatwacked 534

Posted August 4, 2022

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41% of patients (254 of 624) in the XIFAXAN 550 mg group,

31% of TARGET 1 placebo group (98 of 314) and

32% of TARGET 2 placebo group (103 of 320) experienced adequate relief of IBS signs and symptoms.

Composite endpoint was defined as ≥30% decrease from baseline in abdominal pain

I don't see much difference between placebo and Xifaxan.

Antibiotics kill off the beneficial bugs in us as well as the bad, so anything to improve the environment in the gut would prove benificial. Home made dill pickles, fermented in salt and not sterilized helped me with lactose intolerance. NOT PICKLED with vinegar.

Commercial milk has a 5:1 omega 6 to 3 ratio. 100% Grass fed milk is 1:1 and Organic milk is 3:1. Omega 6 is proinflammatory.

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About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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