Can Some Celiac Disease Be Treated with More than Just a Gluten-free Diet?

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By Jefferson Adams

August 5, 2016
By Jefferson Adams • August 5, 2016

Can Some Celiac Disease Be Treated with More than Just a Gluten-free Diet?

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Celiac.com 08/05/2016 - Currently, a gluten free diet is the only option for treating celiac disease. Still, there are numerous patients who follow the diet, but do not respond fully clinically or histologically.

What options do doctors have to treat celiac disease beyond a gluten-free diet? A team of researchers wanted to find out. The research team includes S. Kurada, A. Yadav, and DA Leffler of the Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, and the Celiac Research Program at Harvard Medical School, and the Department of Medicine at Boston Medical Center’s Boston University School of Medicine in Boston, Massachusetts.

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The team conducted a search of PubMed and Open Original Shared Link to highlight celiac disease articles that use keywords including 'celiac disease' and 'refractory celiac disease' and focused on articles conducting pathophysiologic and therapeutic research in/ex-vivo models and human trials.

They then zeroed-in on developing therapies that influence these processes, including tight junction regulators, glutenases, gluten sequestrants and immunotherapy using vaccines, nanoparticles that may serve as adjuncts to a gluten-free diet, or maybe even allow for gluten consumption.

Their subsequent paper also highlight the role of anti-inflammatories, immunosuppressants and monoclonal antibodies in refractory celiac disease.

According to the commentary of their expert, "therapies including tight junction regulators and glutenases have the potential to be approved for non-responsive celiac disease, or as gluten adjuncts."

The team expect results of various phase 1/2 trials using AMG 714, BL 7010, IgY antibodies to be published. In the interim, They plan to treat refractory celiac disease with off-label use of 5 amino-salicylates, budesonide, nucleoside analogues and newer biologics developed for other inflammatory diseases.

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Guest Lynn Holtmeyer

Posted August 18, 2016

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I am currently facing a decision: Diagnosed with celiac in 2009. Last endoscopy in 2013 showed healing of small intestines, some duodenal scalloping still present.

I developed psoriasis vulgaris over 15% of my body. I am presently being offered Stelara as a treatment. How will this affect my celiac ...positive or negative?

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Guest Leaky gut

Posted November 7, 2016

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A huge piece of the puzzle for me was reducing dairy and sugar consumption to minimal AND eliminating NSAIDs and other drugs that promote leaky gut.

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Guest Altinoy Kamilova

Posted March 20, 2017

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Very interesting information.

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About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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