Celiac Autoimmunity in Type I Diabetes Mellitus

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
Record is Archived
This article is now archived and is closed to further replies.
By Jefferson Adams

February 10, 2015
By Jefferson Adams • February 10, 2015

Celiac Autoimmunity in Type I Diabetes Mellitus

Followers 0
Reviewed and edited by a celiac disease expert.
Celiac.com 02/10/2015 - A number of studies have shown a connection between celiac autoimmunity and type 1 diabetes mellitus (T1DM). Doctors recommend celiac screening for T1DM patients, but screening is not always conducted.

Meanwhile, reports about the impact of celiac autoimmunity in T1DM have been varied. A team of researchers recently set out to determine rates of celiac autoimmunity in patients with T1DM, and to study the impact of celiac autoimmunity on nutritional parameters, glycaemic control, endocrine axes and bone health.

Celiac.com Sponsor (A12):
The research team included A.S. Joshi, P.K. Varthakavi, N.M. Bhagwat, M.D. Chadha, AND S.S. Mittal. They are variously associated with the Department of Endocrinology of Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai Central in Maharashtra, India.

For their study, the team conducted celiac autoimmunity screens on eighty-six consecutive patients with T1DM using immunoglobulin A (IgA) tissue transglutaminase as a marker (TTG; IgG anti-gliadin in IgA-deficient case). They compared CA positive (CA+) T1DM cases with age-matched and sex-matched CA negative (CA-) T1DM cases for anthropometry, glycaemic control (as assessed by glycated haemoglobin (HbA1c) and hypoglycaemic/hyperglycaemic episodes), endocrine (thyroid function, cortisol, growth hormone (GH) axis, gonadal axes), haematological (haemoglobin, iron profile and vitamin B12 status) and calcium metabolism parameters and bone densitometry (by dual-energy X-ray absorptiometry (DXA)).

Consenting patients with celiac autoimmunity also underwent upper gastrointestinal (GI) endoscopy with duodenal biopsy.

Results showed that 11 of the 86 patients, about 12.75%, screened positive for celiac autoimmunity. Of those, seven patients underwent duodenal biopsies which suggested two cases of Marsh grade III, three cases of Marsh grade II and two cases of Marsh grade I celiac disease.

In terms of anthropometry, CA+ T1DM patients were comparable with CA- T1DM patients. Overall, CA+ patients had higher HbA1c (10.7±1.8 vs. 8.4±1.0 (93±19 vs. 68±11 mmol/mol); p

The incidence of fractures in the past 3 years was four CA+ patients, and one CA- patient (p<0.05).

There is an important autoimmune connection between celiac disease and T1DM. For people with T1DM, celiac disease adversely affects stature, bone health, glycaemic control and iron and B12 levels.

The study team recommends that IgA sufficiency be established before using an IgA-based screening test for celiac autoimmunity.

Source:

Open Original Shared Link
autoimmunity

celiac

diabetes

mellitus
Share
https://www.celiac.com/celiac-disease/celiac-autoimmunity-in-type-i-diabetes-mellitus-r3291/
Followers 0
Go to articles
User Feedback
- 2 Comments
Recommended Comments

Guest Rebecca

Posted February 16, 2015

Share this comment

My son was diagnosed with type 1 at 12 months old. At 12 years old after years of trying to figure out why he stopped growing on the growth chart, he was finally diagnosed with celiac. He had complete atrophy of the villi. The first year gluten free he grew 6 inches and gained 20 pounds. The good news is he's a college athlete today and as healthy and happy as ever. These diagnosiss don't mean the end of a great quality of life

Link to comment

Share on other sites

Guest Robin

Posted February 17, 2015

Share this comment

You may add me to the list of being diabetic 45 years and 1 1/2 years with celiac disease. Thank you for posting this connection of the 2 autoimmune disease, so maybe doctors will start testing for celiac when they see the person with diabetes having gut issues instead of treating for spastic colon and irritable bowel with medicine for years. THANK YOU

Link to comment

Share on other sites

This is now closed for further comments
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

>VIEW ALL ARTICLES BY JEFFERSON ADAMS
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Gluten-Free Diet Improves Growth and Diabetic Control in Children with Type 1 Diabetes Mellitus and Celiac Disease
Arch Dis Child 2004;89:871-876. Celiac.com 07/12/2005 – Australian researchers have determined that a gluten-free diet in children with Type 1 diabetes mellitus and celiac disease can improve both growth and diabetes control. In the study 21 children (mean age 7.5 years) with both conditions went on a gluten-free diet for 12 months, and their growth and insulin dosages were carefully measured and compared with that of two matched diabetic, non-celiac controls. The group on a gluten-free diet showed significant increases in weight and body mass index compared with the control group, although an increase in height found in the study was not found to be significant. At the time of diagnosis insulin dosages for the celiac disease group were less than that of the control group, but b...

Read Full Article...

0 comments

8,581 views
Anti-infectious and Autoimmune-associated Autoantibodies in Patients with Type I Diabetes Mellitus and Celiac Disease
Celiac.com 09/24/2009 - Could a reduced level of antibodies against infectious agents indicate a protective role for such infections in T1DM development in susceptible individuals? Recent research points in that direction. Type 1 diabetes mellitus (T1DM) is an autoimmune disease with intricate and poorly understood associations between genetic and environmental factors.
A joint Israeli-Colombian research team recently set out to examine the connections between anti-infectious antibodies and autoimmune-associated autoantibodies in patients with Type I diabetes mellitus and their close family members. Among other things, their findings confirmed a strong association between celiac disease and Type 1 diabetes mellitus.
The research team was made up of Ilan Krause, Juan Manuel Anaya...

Read Full Article...

1 comment

9,170 views
Celiac Disease in Type 1 Diabetes Mellitus
Celiac.com 08/20/2012 - People with Type 1 Diabetes (T1D) suffer from celiac disease at rates ranging from 4.4 to 11.1%, compared with rates of 0.5% for the general population.
The reason for this connection is due at least in part to the fact that the HLA genotypes DR3-DQ2 and DR4-DQ8 are strongly associated with T1D, while DR3-DQ2 is associated with celiac disease.
To get a better sense of the issue, a research team recently assessed celiac disease in type 1 diabetes mellitus.
The research team included Maria Erminia Camarca, Enza Mozzillo, Rosa Nugnes, Eugenio Zito, Mariateresa Falco, Valentina Fattorusso, Sara Mobilia, Pietro Buono, Giuliana Valerio, Riccardo Troncone, and Adriana Franzese.
The are variously affiliated with the Department of Paediatrics, "Federico II"...

Read Full Article...

0 comments

13,661 views
Rates of Celiac Disease in People with Type 1 Diabetes Mellitus in Western Sicily
Celiac.com 12/25/2012 - The connection between celiac disease and type 1 diabetes mellitus is well known. Up to now, very little has been reported about rates of celiac disease in children and adults with type 1 diabetes in Sicily.
A team of researchers recently set out to assess the prevalence of celiac disease in patients with type 1 diabetes mellitus who come from a specific region of western Sicily and to assess the clinical features of these patients.
The research team included D. Greco, M. Pisciotta, F. Gambina, and F. Maggio of the Division of Diabetology at Paolo Borsellino Hospital in Marsala, Italy.
For their study, they analyzed data from 492 consecutive patients with type 1 diabetes mellitus who were referred over a five year period.
They found that, of the 49...

Read Full Article...

0 comments

10,400 views
Recent Activity
1. 6 hours ago - Kathleen JJ replied to Kathleen JJ's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  Options - 7 year old boy - Helicobacter pylori and serology
  
  And yes, of course it's better to know and we will adjust. It's just, he's 7 and in our house we can control what he gets. But he plays soccer 3 times a week and in the changing room the boys share candies. I can and will tell him not to accept them any more, but "mistakes" will be made. I'm really burdened by the potential social impact...
2. 6 hours ago - StaciField replied to StaciField's topic in Related Issues & Disorders
  6
  
  My bone structure is disintegrating and I’m having to have my teeth removed
  
  I’m 41. You have helped me achieve the goals of finding a way of getting nutrients into my body so I will see how it works for me. Thank you so much.
3. 6 hours ago - Kathleen JJ replied to Kathleen JJ's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  Options - 7 year old boy - Helicobacter pylori and serology
  
  Thank you for your reaction. The reference values are both "<10", although I found a medical paper from Netherlands (I'm Belgian) who use the same values and there the see a positive daignosis as twice more then 200 and a positive biopsie. I didn't see how to change this in my original message, sorry...
4. 6 hours ago - cristiana replied to Kathleen JJ's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  Options - 7 year old boy - Helicobacter pylori and serology
  
  Hi Kathleen Welcome to the forum. I am based in the UK so I am just picking this post up before our US based moderators appear. I think they will want to know the lab values of both of the figures you have provided us with (min/max reading) as they tend to vary - could you post those for us, please? We see a lot of coeliacs who also have helicobacter...
5. 7 hours ago - Kathleen JJ posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  Options - 7 year old boy - Helicobacter pylori and serology
  
  Hi all, I'm very new at this and 'this' has been quite a rollercoaster ride. Last august my 7 year old son suddenly had these colic like pain attacks that would come a few times per day/night during 10 days. Because they were that bad and because our older daughter had her appendix taken out at 7, we ended up at ER twice to have him checked...