Celiac Disease Possible in Juvenile Idiopathic Arthritis Patients with no Celiac Symptoms

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By Jefferson Adams

December 13, 2021
By Jefferson Adams • December 13, 2021

Celiac Disease Possible in Juvenile Idiopathic Arthritis Patients with no Celiac Symptoms

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Reviewed and edited by a celiac disease expert.

A new study shows that JIA patients with no celiac symptoms can still have celiac disease.

Caption: The Juvenile Arthritis Black and White Gala Ball. Image: CC BY-SA 2.0--bodypainterssydney

Celiac.com 12/13/2021 - Celiac disease is potentially connected to juvenile idiopathic arthritis (JIA). A team of researchers recently set out to determine the serological incidence of celiac disease in patients with JIA.

For their study, the team enrolled seventy-eight patients children under 16 years of age with JIA, who had not responded well to routine treatment, and who visited the pediatric centers of Tehran University of Medical Sciences between 2017 and 2019. The team also assessed the various manifestations of celiac disease, and measured celiac disease-related serological screening tests.

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Average subject age was about 8 years old, plus or minus about 4 years. years. Three patients with oligoarticular JIA had Anti-TTG-Ab levels above normal. None had celiac symptoms.

Data showed no significant statistical differences in terms of growth disorders, sex distribution, and different subtypes of JIA between the sero-positive and sero-negative groups.

The team confirmed one case of celiac disease by pathology, and recommended a gluten-free diet for the patient.

Their main takeaway from the data is that celiac disease is still possible, even in JIA patients with no celiac symptoms.

Read more in the Archives of Iranian Medicine. 2021 Oct 1;24(10):783-785.

The research team included N Payman Sadeghi, Kobra Salari, Vahid Ziaee, Nima Rezaei, and Kambiz Eftekhari. They are variously affiliated with the Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran; the Pediatric Rheumatology Iranian Society; the Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; the Pediatric Gastroenterology and Hepatology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran and the Department of Pediatrics, Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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ekh 2

Posted December 20, 2021

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Very interesting. I am 83 years old, from around the age of 6 years old I suffered from joint pain. At that time the pain was mostly located in my knee joints. The Doctors never really told my parents what the problem was. By the time I was in my late twenties the pain had traveled to many of my joints, including "small" joints. In 1978 I was diagnosed with celiac by a research Dr., except I was to ill for them to do any biopsy removals! But with the removal of gluten, all joint pain disappeared only to return when I was "gluttoned"!

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About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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