Celiac Disease Tied to Antiphospholipid Syndrome and Affects on Fertility and Bone Health

Celiac.com 12/27/2023 - Researchers Aljoharah Al Saud and Ziad F. Rayes deliver a case study report on the uncommon but impactful coexistence of celiac disease and antiphospholipid syndrome, two conditions with links to infertility. Respectively, they are associated with the Family Medicine and Polyclinics, Alfaisal University College of Medicine, and Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Centre, in Riyadh, SAU.

The journey began for a 23-year-old woman with seemingly unrelated symptoms—urticaria and vitamin D deficiency. Initially diagnosed with idiopathic urticaria, her health story unfolded over 13 years. Recurrent miscarriages became a recurring theme, casting shadows on her dream of motherhood. The puzzle pieces started to fit together when antiphospholipid syndrome was identified after multiple pregnancy losses.

Symptoms of Osteoporosis

Celiac.com Sponsor (A12):
The patient's persistence paid off as she successfully underwent in vitro fertilization, leading to a diamniotic dichorionic pregnancy. However, post-delivery brought an unexpected twist—severe back pain unveiling acute wedge fractures, a sign of osteoporosis.

Diving deeper into investigations, elevated antigliadin and anti-tissue transglutaminase antibodies emerged, revealing the presence of celiac disease. A gluten-free diet became the transformative key, bringing not only relief from symptoms but also notable improvements in bone mass density.

This case serves as a poignant reminder of the intricate links between seemingly unrelated health issues. The intersection of celiac disease and antiphospholipid syndrome highlights the importance of thorough investigations in cases of unexplained infertility and unexpected osteoporosis.

Beyond its diagnostic implications, this case underscores the critical need for early identification of celiac disease. Swift action can mitigate its potentially detrimental effects on fertility and bone health. As healthcare continues to unveil the complex interplay of various conditions, stories like these emphasize the significance of holistic and timely approaches to diagnosis and treatment, ensuring a healthier and more informed future for individuals navigating the intricate landscape of their well-being.

Read more in cureus.com