Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    Celiac Vaccine Clears First Big Clinical Trial

    Reviewed and edited by a celiac disease expert.

    Will a vaccine work against celiac disease?

    Celiac Vaccine Clears First Big Clinical Trial - Photo: Andres Rueda
    Caption: Photo: Andres Rueda

    Celiac.com 04/03/2017 - Massachusetts biotech firm ImmusanT has announced the successful completion of its first phase 1b trial of Nexvax2, an immunotherapy drug designed to protect celiac sufferers from the adverse effects of gluten exposure, including gastrointestinal symptoms, such as diarrhea, abdominal pain and bloating.

    Nexvax2 is a drug that relies on three peptides designed to promote T cells involved in the inflammatory reaction in celiac disease to become tolerant to gluten. The company hopes that an initial course will promote gluten-tolerance, which can then be maintained by periodic boosters of the vaccine.

    Celiac.com Sponsor (A12):
    The phase 1b trial in 38 patients showed no issues with safety or tolerability, and indicated that the immunotherapy seemed to work as designed.  The study also helped ImmusanT to determine dosages for phase 2 trials to determine if Nexvax2 can protect patients on a gluten-free diet from inadvertent gluten exposure, which ImmusanT sees as the quickest route to approval.

    If Nexvax2 proves to be effective in preventing accidental gluten exposure in celiac patients, the company plans a follow-up program to see if immunotherapy with Nexvax2 can eliminate the need for a gluten-free diet in celiac patients; a step that represents a daunting challenge, and is somewhat of a Holy Grail for celiac researchers.

    ImmusanT is also developing diagnostic protocols for the vaccine, which are designed to guide its use and help improve diagnosis rates.

    Nexvax2 is just the latest in a large crop of auxiliary treatments aimed at celiac disease. Switzerland's Anokion teamed up with Japanese pharma Astellas in 2015 to form Kanyos, a company working on an immunotherapy for celiac disease along with type 1 diabetes. A company called Sanofi is also working with Selecta on a similar approach.

    Meanwhile, in 2013 AbbVie licensed rights to Alvine Pharmaceuticals AVL003, an oral therapy designed to break down gluten in the GI tract before it can cause damage.

    So, stay tuned celiac sufferers, the next few years could produce some very interesting new treatments for celiac disease, something considered impossible just ten years ago.

    Source: Fierce Biotech



    User Feedback

    Recommended Comments



    Guest Dee

    No thanks. We don't really need bread to survive. Celiac disease has contributed to my RA, MS, Sjogren's, and OP. How would I know one vaccine would not trigger response that is not foreseen? Sometimes we guinea pigs for the drug companies. They are trying to treat the symptom, not the cause. Further down the road, we will see what this has done to people.

    Link to comment
    Share on other sites
    Guest JStinson

    Posted

    Sure get a vaccine that supposedly cures an autoimmune disease that was most likely caused by vaccines...makes sense if you don't mind following the big pharma religion to the grave.

    Please site the evidence that vaccines cause celiac disease.

    Link to comment
    Share on other sites
    Guest Jefferson Adams

    Posted

    Catryna White - Celiac disease was first identified in ancient Greece - they didn't have vaccines! Celiac health improved during World Wars due to lack of flour. If you look at the history of celiac disease and it's genetic trait you wouldn't believe such rubbish.

    Thanks for commenting!

    Link to comment
    Share on other sites
    Guest Jefferson Adams

    Posted

    Gluten is destructive for many people. Why develop a vaccine against it? Get rid of the glyphosate soaked wheat! Get to the root cause of the problem. We need food that is healthy and nutritious, not harmful to us.

    That story about glyphosate-soaked wheat is also a myth. There is zero actual evidence to support those claims. There is zero evidence that glyphosate causes celiac disease. Much greater chance that things like reovirus are a cause. Also, using your logic, you might just as well say: Smallpox is destructive for many people. Why develop a vaccine against it? The logic just doesn't work.

    Link to comment
    Share on other sites
    Guest Jefferson Adams

    Posted

    No thanks. We don't really need bread to survive. Celiac disease has contributed to my RA, MS, Sjogren's, and OP. How would I know one vaccine would not trigger response that is not foreseen? Sometimes we guinea pigs for the drug companies. They are trying to treat the symptom, not the cause. Further down the road, we will see what this has done to people.

    You do realize that one reason humans are actually alive in such large numbers is because of bread? You do realize that the vast majority of people have zero problem with wheat and bread, that they are actually part of a healthy diet for most people? Lastly, I didn't feel like a guinea pig when I got my polio vaccine. Not sure where you're coming from on this.

    Link to comment
    Share on other sites
    Guest Brent

    Posted

    Gluten is in much more than bread sadly. If I could just not eat wheat bread, my life would be great. Cross contamination is what makes coeliac diease so hard to live with.

    Link to comment
    Share on other sites
    Guest Rebecca

    Posted

    I appreciate Dan's comments. My daughter has Celiac and Hashimoto's, and while I will not rush to try any vaccine for her, I do believe that inflammation related to these autoimmune conditions is very destructive to the whole body. I am grateful for any and all research done in these areas. I am not a fan of big pharm and we have tried many challenging diets and supplement protocols to try to get to the root of my daughters problems without luck. She is of course, 100% gluten-free, and that is relatively easy for her but it is not relieving all of her auto immune issues. I cannot even find traditional docs that have a clue in treating auto immune. Any kind of research and testing that sheds some light in this area is a step forward.

    Link to comment
    Share on other sites



    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 07/25/2016 - Celiac disease is one of the most common immune-mediated diseases. Often, a gluten-free diet does not fully control celiac symptoms and disease activity.
    Even though no new therapies have been approved, a growing effort, coupled with a rapidly expanding knowledge of the regulatory pathway could soon lead to new breakthroughs.
    A team of researchers recently reviewed the epidemiology, pathophysiology, and current treatment paradigm for celiac disease. The researchers were M Wungjiranirun, CP Kelly, and DA Leffler, both of the Division of Gastroenterology at the Celiac Center of Beth Israel Deaconess Medical Center in Boston, Massachusetts, USA.
    They also reviewed the major types of therapies being proposed for celiac treatment, and expounded broadly upon...


    Jefferson Adams
    Celiac.com 07/19/2016 - The world's first vaccine aimed at curing celiac disease is slated to begin full trials later this year, and residents of the Australian state of Victoria will be among the first humans to give it a try against celiac disease.
    The vaccine, called Nexvax2, was developed by Australian scientist Dr Bob Anderson, and is aimed at giving celiac patients a chance to overcome their immune reaction to the gluten found in products containing wheat, rye and barley. Nexvax2 aims to de-sensitise patients to three peptides contained in gluten that trigger a damaging reaction in their immune system.
    Previous trials on 150 patients from Melbourne, Perth, Adelaide, Brisbane and Auckland were aimed at finding a safe dosage rather than assessing its ability to beat celiac disease...


    Jefferson Adams
    Takeda Taps PvP Biologics to Develop Celiac Disease Therapy
    Celiac.com 03/10/2017 - PvP Biologics, a business spun out of the University of Washington, now has a $35 million deal with Takeda Pharmaceutical to develop its therapy for celiac disease. PvP Biologics is developing an enzyme that can be taken orally and survive in the harsh acidic environment of the stomach. That enzyme is called KumaMax.
    Under the terms of the agreement, Takeda will fund $35 million in PvP's research and development of the therapy through phase 1 clinical trials. The agreement gives Takeda Pharmaceutical the exclusive option to acquire PvP for an undisclosed fee upon successful completion.
    PvP Biologics has its roots in a University of Washington tech incubator program, but spun out on its own in 2016, in advance of its arrangement with Takeda.
    Says Adam Simpson...


    Jefferson Adams
    Enzyme Shows Promise In Dissolving Gliadin Peptides in Celiac Patients
    Celiac.com 03/27/2017 - A number of researchers are looking to provide alternative or adjunct treatments to the gluten-free diet in celiac disease. Meanwhile, a number of companies are currently developing a wide variety of such options, ranging from various kinds of enzyme therapies, to treatments that eliminate celiac disease reactions, even to vaccines to inoculate celiac sufferers against their condition, perhaps allowing for full recovery and a return to non-gluten-free eating habits, as desired. At least, that's one dream.
    More likely will be the development of enzymes or other treatments that offer celiacs varying degrees of protection from gluten ingestion. Most likely, such treatments would be designed to augment an existing gluten-free diet, and to provide protection against...


  • Recent Activity

    1. - PixieSticks replied to PixieSticks's topic in Super Sensitive People
      2

      Working in a kitchen with gluten?

    2. - BoiseNic replied to BoiseNic's topic in Dermatitis Herpetiformis
      11

      Skinesa

    3. - knitty kitty replied to Whyz's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      Feeling ill

    4. - Scott Adams replied to Brianne03's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Advantages vs. Disadvantages of having an official Celiac diagnosis

    5. - Scott Adams replied to Whyz's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      Feeling ill


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,525
    • Most Online (within 30 mins)
      7,748

    MaddieJoy05
    Newest Member
    MaddieJoy05
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.5k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Whyz
      6
    • Art Maltman
      6
    • JA917
      13
    • Dana Gilcrease
      5
    • marion wheaton
      6
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...