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  • Scott Adams
    Scott Adams

    COVID-19 a Possible Trigger for Celiac Disease in Those with Genetic Risk

    Reviewed and edited by a celiac disease expert.

    A research team predicts a possible rise in celiac disease due to impact of Covid-19 infections.

    COVID-19 a Possible Trigger for Celiac Disease in Those with Genetic Risk - Image: CC BY 2.0--Official U.S. Navy Imagery
    Caption: Image: CC BY 2.0--Official U.S. Navy Imagery

    Celiac.com 06/28/2021 - There is a growing body of data to suggest the intestinal action of SARS-CoV-2, with ciliated cells and intestinal enterocytes serving as target cells, due to high expression of ACE2 and TMPRSS2, could possibly trigger celiac disease in predisposed individuals.

    Indeed, COVID-19 promotes a “cytokine storm” in the intestinal mucosa, triggering epithelial damage that increases barrier permeability, permitting gliadin to "leak" into the intestinal lamina. However, the possible impact of the SARS-CoV-2 infection, and the resulting disease, on celiac disease rates remains unknown, with no data currently available on the development of systemic disorder, or on long-term outcomes. 

    Celiac.com Sponsor (A12):
    A team of researchers recently set out to highlight the potential risk of a rise in celiac disease rates among genetically predisposed subjects following SARS-CoV-2 infection, based on several factors which could promote the development of celiac disease.

    The research team included Chiara Maria Trovato, Monica Montuori, Nicoletta Pietropaoli, and Salvatore Oliva. They are variously affiliated with the Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy; and the Hepatology Gastroenterology and Nutrition Unit, "Bambino Gesù" Children Hospital, Rome, Italy. 

    The team used current medical literature to help them hypothesize the role of COVID-19 as a possible trigger for celiac disease development in predisposed individuals. They suggest that genetically predisposed people could be more likely to develop celiac disease following SARS-CoV-2 infection, making COVID-19 a potential driver of increased celiac disease cases in the future.

    An unexpected rise in celiac cases among genetically predisposed individuals in the wake of the COVID-19 pandemic would support the team's hypothesis. Time will tell if they are right. Stay tuned for more stories regarding COVID-19, celiac disease, and related topics.

    Read more in the International Journal of Clinical Practice



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    Tintern21
    On 11/19/2021 at 4:28 PM, Guest New2Celiac said:

    Hi everyone,

    I've have been claiming this for awhile now and delighted to see research on the topic. Perhaps it's coincidental, however prior to my C19 vaccine I would've had a slight gluten intolerance only pasta - following the vaccine and some associated intestinal distress, my symptoms worsened and now I can't have a crumb without having the same symptoms as a diagnosed celiac would have. I do not regret the vaccine nor advocate in anyway it was my choice, I simply find the correlation between the two interesting and wonder if this may be a factor. I hope this doesn't lead to a debate vaccines 🙄 

    Me too. OMG can we have a page dedicated to this celiac.com a want to hear others views

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    Scott Adams

    Feel free to start a forum discussion on this topic.

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    Tintern21
    On 7/7/2021 at 4:56 PM, Makky said:

    This is extremely interesting to note, my celiac symptoms began about a month after receiving the first covid vaccine. Now I wish I never got it!

    Mine too, although was almost immediate

     

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    Guest Dee
    On 7/5/2021 at 11:33 PM, Guest Pam N. said:

    I had noticed an association between the symptoms of long-term COVID and celiac disease and wondered if COVID could have triggered the disease in some folks. I have seen people who developed celiac disease after being ill or injured. I hope this leads to more people with long-haul COVID being tested for celiac disease.

    I can testify to their findings - I have long covid and have also been diagnosed with now having coeliac disease along with Pan-gastritis.  Thanks covid 19 for giving me this life long condition. I will be 60 yrs of age this year( 2022) and have always been really fit - Running/ spinning classes along with sit ups etc now I'm all on walking my dog. Dee Thompson GB 

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    Guest Mimi
    On 7/7/2021 at 11:56 AM, Makky said:

    This is extremely interesting to note, my celiac symptoms began about a month after receiving the first covid vaccine. Now I wish I never got it!

    My son just tested positive on the ttg iga blood test (celiac test) and per 23and me has one of the main genes. We are at UNC Health. UNC developed and continues to develop the mRNA technology for vaccines.  They have been so very resistant to completing the evaluation for a diagnosis to the point I started researching to find out why. Yes there are indicators that the vaccine triggers autoimmune and also that it the mRNA could be causing it. 

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    Tintern21
    15 hours ago, Guest Mimi said:

    My son just tested positive on the ttg iga blood test (celiac test) and per 23and me has one of the main genes. We are at UNC Health. UNC developed and continues to develop the mRNA technology for vaccines.  They have been so very resistant to completing the evaluation for a diagnosis to the point I started researching to find out why. Yes there are indicators that the vaccine triggers autoimmune and also that it the mRNA could be causing it. 

    Hi, thanks for posting. Do you have any links you can share to show the vaccine can trigger it. I 100% believe it was the trigger for me and would be great it we can pull together evidence on here to help others. I'm sorry now has it xx

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    Scott Adams

    Links are not evidence...I would only add that only published studies on this should be shared, not anecdotal evidence. There is also such a thing called coincidence, and when hundreds of millions of people are getting a shot, even if that shot were just secretly full of water, there would be many people making all sorts of claims about the negative health effects caused by it. It's just the nature of the beast. Hopefully there will be more studies done on this, but my hope here is to share scientific information that shows a correlation. 

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    Tintern21
    44 minutes ago, Scott Adams said:

    Links are not evidence...I would only add that only published studies on this should be shared, not anecdotal evidence. There is also such a thing called coincidence, and when hundreds of millions of people are getting a shot, even if that shot were just secretly full of water, there would be many people making all sorts of claims about the negative health effects caused by it. It's just the nature of the beast. Hopefully there will be more studies done on this, but my hope here is to share scientific information that shows a correlation. 

    Agreed on sharing evidence links. We should all be able to be heard and have this forum to express our concerns given we are not able to get assistance from many of our usual forns such as local doctors. I can't comment on what is happening in the US. But here in the UK there is a deliberate intention to mock and discredit anyone that has concerns about the vaccine, I appreciate all that have come forward with their experiences and am attempting to support. 

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    trents
    5 minutes ago, Tintern21 said:

    Agreed on sharing evidence links. We should all be able to be heard and have this forum to express our concerns given we are not able to get assistance from many of our usual forns such as local doctors. I can't comment on what is happening in the US. But here in the UK there is a deliberate intention to mock and discredit anyone that has concerns about the vaccine, I appreciate all that have come forward with their experiences and am attempting to support. 

    It is the same here in the USA IMO. No dissent allowed. And I speak as one who has chosen for myself to get vaxed 3x.

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    Tintern21
    2 minutes ago, trents said:

    It is the same here in the USA IMO. No dissent allowed. And I speak as one who has chosen for myself to get vaxed 3x.

    Sadend to hear that its is the same. Very pleased  people are able to express themselves on here with very very valid concerns and not be censored in that way. I do understand Scott Adams point about evidential links but these are few and far between, and wonder if this is lack of scientific investigation or internet censorship. 

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    Scott Adams

    I think the covid-19 research is coming out, just slowly. When it is published we do summarize it, and here are some past summaries:

    https://www.celiac.com/search/?q=covid-19&type=cms_records2&updated_after=any&sortby=newest&search_in=titles

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    Kristy Bliss

    I am 51 and never had issues eating wheat until the middle of last year. Now a small amount causes major issues. 

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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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