Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    Does Celiac Disease Protect Against Aspects of Type 1 Diabetes Mellitus?

    Reviewed and edited by a celiac disease expert.
    Does Celiac Disease Protect Against Aspects of Type 1 Diabetes Mellitus? -

    Celiac.com 07/22/2011 - Many reports indicate a hypercoagulative state in diabetes mellitus as result of endothelial damage. Numerous researchers have reported a strong association between type 1 diabetes mellitus (DM1) and celiac disease.

    Clinical data indicate that vascular dysfunction can result from a cascade of biochemical events triggered by a metabolic malfunction. The net result changes the cells that line the interior surface of the blood vessels; from a surface called a thrombo-resistant surface to one called a thrombo-genic surface.

    Celiac.com Sponsor (A12):
    A research team recently set out to determine whether celiac disease in a group of DM1 patients is connected with a different expression of certain hemostatic factors, and with a different manifestation and/or progression of microvascular complications of DM1, as compared to patients with diabetes alone.

    For the study, the team enrolled ninety-four adult patients with DM1, who they then screened for celiac disease. They found anti-endomysial antibodies (EMA) in 13 of 94 DM1 patients (13.8%). The team then confirmed celiac disease diagnosis by histology and organ culture.

    The mean age and duration of DM1 of patients also affected by celiac disease were similar to those patients with diabetes alone, but the groups showed very different parameters for metabolic control and hemo-coagulation. In DM1 patients with celiac disease those parameters include:

    • Signiï¬cantly lower concentrations of glycosylated hemoglobin (HbA1c) (P.05), cholesterol (P.001), triglycerides (P.001), factor VII antigen (FVII:ag) (P.005), factor VII coagulant activity (FVII:c) (P.05), and prothrombin degradation fragments (F1+2) (P.001).
    • Higher values of activated C protein (APC) (.001).
    DM1 patients with celiac disease showed no retinal abnormalities and no signs of renal damage.

    The results suggest a potential protective role of celiac disease in the pro-thrombotic state of DM1.

    Source:

    • Open Original Shared Link


    User Feedback

    Recommended Comments

    Guest Nicole

    Posted

    Interesting, thanks. I sure would love to know of any studies that look at the case where a celiac diagnosis is made prior to a Type 1 diabetes diagnosis (typically it's the T1 first, then celiac, as I'm sure you know).

    Link to comment
    Share on other sites
    Guest raiskin

    Posted

    This is fascinating. My daughter has both celiac and type 1 diabetes. The combination makes social life difficult (as well as physical health). It is really nice to read something that suggests something positive about celiac other than the many dire possibilities and connections with other diseases!

     

    Thank you for all the work you do! I refer to your safe and unsafe list all the time.

    Link to comment
    Share on other sites
    Guest Valeria

    Thank you for the good news. I am type 1 diabetic diagnosed 40 years prior to coeliac. I showed a mild retina alteration about 30 years ago. ever since then i have not developed any further diabetes complication to the amazement of my diabetes doctor.

    Link to comment
    Share on other sites
    Guest Holly

    This is a really interesting article. I am both a type one diabetic and have celiac disease. I got type 1 when I was five years old and now am 21. I am hanging on by a thread with it because being on an insulin pump tends to be a real struggle for me because of skin irritation and the sites giving me issues but I cope with it. When I was a sophomore in high school I was tested for celiac disease because my endocrinologist had a strong feeling that I was carrying the symptoms for it. She sent me to a doctor she recommended and turned out I was borderline celiac and still am. I can't say I follow the celiac diet to a T because it is hard to handle and keep in line but I try my best and try to cut out gluten in my diet as often and much as possible. I face the fact that nothing is perfect and celiac is a tough thing to deal with. A combination of both these diseases really hit hard and already having diabetes since 11 years prior really scared me because many of the alternatives include rice and high starch and carbohydrate food products and being on an insulin pump, your goal is to eat healthy and try to eliminate those types of things as much as possible to control sugar as well as keep your insulin intake down. I am personally turned off by rice and the thoughts of eating it just scare me because I always feel awful afterwards. I choose to not eat it even though I am celiac dependent. All I can say to anyone who is in this type of situation is to take everything day by day, you can definitely take it on if you put your mind to it. It is hard but everything in life is and this is just another step you have to take to make it through your life and to live a healthy and happily as well. Good luck to all.

    Link to comment
    Share on other sites
    Guest Haley

    Posted

    Thank you for this article and also thanks to the comment by Holly. I was diagnosed with Type 1 at age 3 and am now 31. I was on in insulin pump from 2004 until this past January, when my pump broke and I decided to try injections for a time. I also have problems with irritation of the skin and wanted to see if using injections would work. I have now been on injections for 5 months and my HbA1C has run about the same as when on the pump. You might give the pump a rest for a few months and then try again. Sometimes I think that we need a break.

     

    Also, I started having stomach issues last year and was finally diagnosed with gluten sensitivity, along with other sensitivities to rice, pork, chicken, beef, soy, corn, pumpkin and coconut. What am I supposed to eat, especially when this culture lives off of rice and chicken?

     

    So, Holly, I understand your dilemmna. Because I live in Thailand, I can't test for celiac, but I could do a test by Enterolab that tested for food sensitivities. You might also check out MRT (Mediator Release Test). If rice irritates your stomach you might also be sensitive to that. I am. When I return to the states this year I will test for celiac disease and other food sensitivities.

     

    Blessings and yes, I agree that if you put your mind to it, you can have a blessed life. It is challenging, no doubt.

    Link to comment
    Share on other sites
    Guest Cathy

    Posted

    Interesting, thanks. I sure would love to know of any studies that look at the case where a celiac diagnosis is made prior to a Type 1 diabetes diagnosis (typically it's the T1 first, then celiac, as I'm sure you know).

    I have celiac disease and dermatitis herpetiformis. My brother also has celiac disease - he was diagnosed about 3 years ago and was just recently diagnosed with Type 1 diabetes. I am now what they are calling borderline diabetic.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    Arch Dis Child 2004;89:871-876. Celiac.com 07/12/2005 – Australian researchers have determined that a gluten-free diet in children with Type 1 diabetes mellitus and celiac disease can improve both growth and diabetes control. In the study 21 children (mean age 7.5 years) with both conditions went on a gluten-free diet for 12 months, and their growth and insulin dosages were carefully measured and compared with that of two matched diabetic, non-celiac controls. The group on a gluten-free diet showed significant increases in weight and body mass index compared with the control group, although an increase in height found in the study was not found to be significant. At the time of diagnosis insulin dosages for the celiac disease group were less than that of the control group, but b...


    Jefferson Adams
    Celiac.com 09/24/2009 - Could a reduced level of antibodies against infectious agents indicate a protective role for such infections in T1DM development in susceptible individuals? Recent research points in that direction. Type 1 diabetes mellitus (T1DM) is an autoimmune disease with intricate and poorly understood associations between genetic and environmental factors.
    A joint Israeli-Colombian research team recently set out to examine the connections between anti-infectious antibodies and autoimmune-associated autoantibodies in patients with Type I diabetes mellitus and their close family members. Among other things, their findings confirmed a strong association between celiac disease and Type 1 diabetes mellitus.
    The research team was made up of Ilan Krause, Juan Manuel Anaya...


    Jefferson Adams
    Celiac Disease in Type 1 Diabetes Mellitus
    Celiac.com 08/20/2012 - People with Type 1 Diabetes (T1D) suffer from celiac disease at rates ranging from 4.4 to 11.1%, compared with rates of 0.5% for the general population.
    The reason for this connection is due at least in part to the fact that the HLA genotypes DR3-DQ2 and DR4-DQ8 are strongly associated with T1D, while DR3-DQ2 is associated with celiac disease.
    To get a better sense of the issue, a research team recently assessed celiac disease in type 1 diabetes mellitus.
    The research team included Maria Erminia Camarca, Enza Mozzillo, Rosa Nugnes, Eugenio Zito, Mariateresa Falco, Valentina Fattorusso, Sara Mobilia, Pietro Buono, Giuliana Valerio, Riccardo Troncone, and Adriana Franzese.
    The are variously affiliated with the Department of Paediatrics, "Federico II"...


    Jefferson Adams
    Rates of Celiac Disease in People with Type 1 Diabetes Mellitus in Western Sicily
    Celiac.com 12/25/2012 - The connection between celiac disease and type 1 diabetes mellitus is well known. Up to now, very little has been reported about rates of celiac disease in children and adults with type 1 diabetes in Sicily.
    A team of researchers recently set out to assess the prevalence of celiac disease in patients with type 1 diabetes mellitus who come from a specific region of western Sicily and to assess the clinical features of these patients.
    The research team included D. Greco, M. Pisciotta, F. Gambina, and F. Maggio of the Division of Diabetology at Paolo Borsellino Hospital in Marsala, Italy.
    For their study, they analyzed data from 492 consecutive patients with type 1 diabetes mellitus who were referred over a five year period.
    They found that, of the 49...


  • Recent Activity

    1. - Wheatwacked replied to pasqualeb's topic in Related Issues & Disorders
      14

      Muscle atrophy in legs

    2. - Wheatwacked replied to aperlo34's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      3

      2 months in... struggling with symptoms

    3. - Wheatwacked replied to Bindi's topic in Super Sensitive People
      37

      Refractory or super sensitive?

    4. - Wheatwacked replied to Savannah Wert's topic in Coping with Celiac Disease
      3

      Hey all!

    5. - Louise Broughton replied to Louise Broughton's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      7

      Louise


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      125,956
    • Most Online (within 30 mins)
      7,748

    Bobbyks69
    Newest Member
    Bobbyks69
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.1k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Dawn R.
      4
    • jadeceoliacuk
      5
    • Gluten is bad
      7
    • pasqualeb
      14
    • Bindi
      37
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...