Fecal Microbiota Transplant Restores Gut Microbiome

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
Record is Archived
This article is now archived and is closed to further replies.
By Jefferson Adams

September 16, 2016
By Jefferson Adams • September 16, 2016

Fecal Microbiota Transplant Restores Gut Microbiome

Followers 0
Reviewed and edited by a celiac disease expert.
Caption: Sufferers of C. difficile infections have new hope in fecal translpants. Photo: CC--Kevin Jarrett.

Celiac.com 09/16/2016 - Great news about poop transplants: They work! And now doctors kind of understand how and why they work. This is good news about a humor provoking, but very serious matter.

Clostridium difficile infection is one of the most common health care-associated infections, and up to 40% of patients suffer from recurrence of disease following standard antibiotic therapy. C. difficile infection has proven to be very difficult to treat. Fecal microbiota transplantation (FMT) has been successfully used to treat recurrent C. difficile infection. Doctors hypothesize that FMT promotes recovery of a microbiota capable of colonization resistance to C. difficile. However, they didn't really understand how it worked.

Celiac.com Sponsor (A12):
Recently, a research team investigated changes in the fecal microbiota structure following FMT in patients with recurrent C. difficile infection, and imputed a hypothetical functional profile based on the 16S rRNA profile, using a predictive metagenomic tool. After FMT, they also noted increased relative abundance of Bacteroidetes and decreased abundance of Proteobacteria.

The research team included Anna M. Seekatz, Johannes Aas, Charles E. Gessert, Timothy A. Rubin, Daniel M. Saman, Johan S. Bakken, and Vincent B. Young. They are variously affiliated with the Department of Internal Medicine, Division of Infectious Diseases, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA; Essentia Health, Department of Gastroenterology, Duluth, Minnesota, USA; Essentia Institute of Rural Health, Duluth, Minnesota, USA; and St. Luke's Hospital, Section of Infectious Diseases, Duluth, Minnesota, USA.

Their results showed that, after transplantation, fecal microbiota of recipients was more diverse, and more similar to the donor profile, than the microbiota before transplantation. Additionally, they observed differences in the imputed metagenomic profile. In particular, amino acid transport systems were over-represented in samples collected prior to transplantation.

These results Indicate that functional changes accompany microbial structural changes following this therapy. Further identification of the specific microbiota, and functions that promote colonization resistance, may help to create better treatment methods for C. difficile infection.

Source:

Open Original Shared Link
fecal

microbiome

microbiota

restores

transplant
Share
Followers 0
Go to articles
User Feedback
- 1 Comment
Recommended Comments

Guest Namklak

Posted September 19, 2016

Share this comment

My celiac disease was triggered by an antibiotic called Augmentin, which is actually two antibiotics at high strength. My wife is a GI nurse, and fortunately I was quickly diagnosed with celiac disease quickly after this event. But as this article points out, the gut biome is painfully under-researched.

This is actually old news, as my wife has participated in these transplants for years, right here in the USA. I've often wondered and discussed with my wife if the right microbiome could help/cure my celiac disease. But obviously the only way to make money from feces is in politics and farming, so medical industry help in this area won't be coming soon.

Link to comment

Share on other sites

This is now closed for further comments
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

>VIEW ALL ARTICLES BY JEFFERSON ADAMS
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Are Commensal Bacteria with a Taste for Gluten the Missing Link in the Pathogenesis of Celiac Disease?
Celiac.com 05/10/2004 - Identical twins enter life from the same womb sharing the same genetic code, the same family, the same home, largely experiencing the same environment as they develop from infancy through childhood and mature into adults. When celiac disease strikes one identical twin, the odds are the other twin also has celiac disease. Twin studies lead to the conclusion that celiac disease is strongly linked to genetic factors. Yet one identical twin may develop celiac disease while the other twin may remain completely free of celiac disease for decades if not for a lifetime.
One study looked at 20 pairs of identical twins and 27 pairs of fraternal twins where at least one twin of the pair was known to have celiac disease. In 75% of the pairs of identical twins, both twins...

Read Full Article...

4 comments

53,489 views
Gut Bacteria Play Significant Role in Gluten Metabolism
Celiac.com 08/06/2014 - Although the role of human digestive proteases in gluten proteins is quite well known, researchers don’t know much about the role of gut bacteria in the metabolism of these proteins. A research team recently set out to explore the diversity of the cultivable human gut microbiome involved in gluten metabolism.
Their goal was to isolate and characterize human gut bacteria involved in the metabolism of gluten proteins. The team included Alberto Caminero, Alexandra R. Herrán, Esther Nistal, Jenifer Pérez-Andrés, Luis Vaquero, Santiago Vivas, José María G. Ruiz de Morales, Silvia M. Albillos and Javier Casqueiro.
They are variously associated with the Instituto de Biología Molecular, Genómica y Proteómica (INBIOMIC), the Área de Microbiología, Facultad de Biología...

Read Full Article...

0 comments

9,763 views
Gut Bacteria Differs in Gluten-free Celiac Patients with Persistent Symptoms
Celiac.com 02/09/2015 - Do you suffer from persistent celiac symptoms in spite of following a strict gluten-free diet and having normal small bowel mucosa? Many celiac patients do. Moreover, typical explanations, such as accidental gluten-intake or the presence of other gastrointestinal disease, do not account for all of the symptoms in these patients.
Recent studies have suggested that changes in intestinal microbiota are associated with autoimmune disorders, including celiac disease.
A team of researchers recently set out to determine if abnormal intestinal microbiota may in fact be associated with persistent gastrointestinal symptoms in gluten-free celiac disease patients. The research team included Pirjo Wacklin PhD, Pilvi Laurikka, Katri Lindfors PhD, Pekka Collin MD, Teea Salmi...

Read Full Article...

2 comments

16,371 views
Gut Microorganisms Cause Gluten-Induced Pathology in Mouse Model of Celiac Disease
Celiac.com 01/18/2016 - How come only 2% to 5% of genetically susceptible individuals develop celiac disease?
Researchers attempting to answer that question have turned their focus to environmental factors, including gut microorganisms, that may contribute to the development of celiac disease.
In a recent study, published in The American Journal of Pathology, researchers using a humanized mouse model of gluten sensitivity found that the gut microbiome can play an important role in the body's response to gluten.
Their data show that the rise in overall celiac disease rates over the last 50 years may be driven, at least partly, by variations in gut microbiota. If this proves to be true, then doctors may be able to craft "specific microbiota-based therapies" that "aid in the prevention...

Read Full Article...

2 comments

8,979 views
Recent Activity
1. 8 hours ago - Wheatwacked replied to Dhruv's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  20
  
  Confused with test results
  
  There is plenty of gluten food that is unplatable also. The trouble in restaurants is that wheat, like the Frank's Hot Sauce commercial; "They throw that bleep on everything." In my opinion, the underlying problem is compromised immune system due to vitamin D deficiency and Green Revolution modern wheat. 50% of the industrialized world are vitamin...
2. 16 hours ago - trents replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  12
  
  Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos
  
  I understand from one of our forum moderators who is UK-based that the benefits of having an official celiac diagnosis varies depending on your postal code. So then, it must be a benefit tied to local government rather than national government.
3. 16 hours ago - Elliebee replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  12
  
  Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos
  
  I think if I gave up gluten and got a negative blood result and stick with it rather than do the gluten challenge (even though I’ve got no symptoms.. yet). think if I gave up gluten and got a negative blood result and stick with it rather than do the gluten challenge (even though I’ve got no symptoms.. yet).
4. 17 hours ago - Scott Adams replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  12
  
  Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos
  
  For anyone interested in research summaries on this topic we have this category: https://www.celiac.com/celiac-disease/celiac-disease-amp-related-diseases-and-disorders/thyroid-pancreatic-disorders-and-celiac-disease/
5. 17 hours ago - trents replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  12
  
  Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos
  
  Obviously, you have looked at all this from various angles and I respect that. But consider this, you could trial the gluten-free diet for six months to see if it results in lower ttg-iga scores. If so, it is another piece of evidence pointing to celiac disease. You could then go off the gluten fast and return to a gluten loaded diet for weeks or months and...