Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    By Jefferson Adams •

    Gluten-Free Diet Reduces Schizophrenia Symptoms in Some Patients

    Reviewed and edited by a celiac disease expert.

    Can a gluten-free diet fuel new schizophrenia treatments? New research shows that a gluten-free diet reduces schizophrenia  symptoms in certain patients.

    Gluten-Free Diet Reduces Schizophrenia Symptoms in Some Patients - Female Warrior. Image: CC--CHRISTIAAN TONNIS
    Caption: Female Warrior. Image: CC--CHRISTIAAN TONNIS

    04/22/2019 - A gluten-free diet can improve symptoms of schizophrenia in certain patients, new research suggests. In the small pilot study, Deanna L. Kelly, PharmD, professor of psychiatry, University of Maryland School of Medicine, Baltimore, and colleagues studied the effects a gluten-free diet in schizophrenia, especially in patients with elevated gluten antibodies.

    Kelly and her team set out to determine whether a gluten-free diet would improve psychiatric symptoms in this subgroup of patients with elevated AGA IgG.

    Celiac.com Sponsor (A12):
     They found that schizophrenia patients with elevated gluten antibodies, specifically, elevated antigliadin antibodies (AGA IgG), who followed a gluten-free-diet for 5 weeks saw a greater reduction in negative symptoms compared counterparts on a non-gluten-free diet.

    "With a gluten-free diet, we do have the potential to improve psychiatric symptoms, particularly negative symptoms, which is a symptom domain with a high unmet clinical need," said lead investigator Deanna L. Kelly, PharmD, professor of psychiatry, University of Maryland School of Medicine, Baltimore.

    Currently, there are no good treatment options for negative symptoms of schizophrenia, "so this could be a treatment for people if they have these antigliadin antibodies," Kelly said.

    Nearly One-third of Schizophrenia Patients Gluten Intolerant

    Elevated AGA IgG may be present in about 30% of all patients with schizophrenia. The antigliadin antibody is not related to the antibodies seen in celiac disease, which affects roughly 1% of the overall population.

    Schizophrenia patients with elevated AGA IgG show substantially lower positive schizophrenia symptoms than those who test negative no AGA IgG. They also have higher levels of kynurenine, a metabolite of the amino acid L-tryptophan. Kynurenine has been linked to schizophrenia pathology, and to other conditions, Kelly noted. The tryptophan kynurenine pathway also has important links to neurotherapy.

    Strategies for treatment of schizophrenia are still largely "one-size-fits-all." The team's study began largely after a single 2-week gluten-free trial in two people with elevated AGA IgG and schizophrenia showed "robust symptom improvements, particularly in the domain of negative symptoms," so we wanted to do a feasibility study and enroll more patients," Kelly told reporters.

    The team's findings were presented at the first annual Congress of the Schizophrenia International Research Society (SIRS) 2019.

    Read more at Medscape Medical News


     Share
    Go to articles

    User Feedback

    Recommended Comments

    Posterboy

    To All,

    This is good research!

    I had recently ran across the Kynurenine (KYN) pathway in my own research.

    It is now been shown as the pathogenic cause of IBS.

    Open Original Shared Link

    And even earlier than that it was linked to Celiac disease Circa 2007.

    Open Original Shared Link

    this research confirms that AGA IgG in Schizophrenia patients are linked conditions in Celiac disease.

    Open Original Shared Link

    Maybe other's will run across this research and bee helped.

    I am never surprised when I find earlier research has been done on a topic but always surprised nobody seems to know about it....yet it has been a couple plus years since the earlier link to AGA IgG and Schizophrenia  symptom's in Celiac's has been established as related.

    This is not medical advice but I hope it is helpful.. .and it doesn't take another 10 + years (Circa 2007) for doctor's to recognize this connection... of the Kynurenine (KYN) pathway as a regulator of immune response in Celiac's.

    Posterboy,

    Link to comment
    Share on other sites
    rweills

    This would be without a doubt for those who struggle with this issue. I was medicated for 27 years on psychiatric medications and never knew I had an intolerance to both gluten and dairy. My life may not be as others for sure with how I walk and carry out things but I can surely say changing the diet could definitely present some opportunities for a change in the mental health realm. I was misdiagnosed for years and on multiple medications until my kidney's started shutting down. Labeled Bi-Polar, severe Depression, Anxiety attacks, etc. I needed to make a desperate change to save my own life so I made the transition of coming off the meds and changing my diet and now I am three years drug free. Much more to the story than I can share right now but gluten has played a very large part within my mental health. Gluten affects many people in different ways, for me I struggled with re-flux for years being placed on different medications for it only to still battle it; my esophagus started eroding. I couldn't sleep to save my life either; only to discover that after making the change and getting off of all gluten did I see the difference. If I come in contact with it now I get seriously sick and it can last for days. The effects of gluten can be harsh on the body in general for anyone, it's just some people are more susceptible to it and it can cause a vast array of issues like "Leaky gut" and other things that really isn't good beside issues with the brain. Something else to keep in mind there is a difference with an "intolerance" compared to an "allergy" that's worth looking into. I am convinced although, that if one continues eating it and they have an intolerance, what are the chances of them possibly developing an allergy??? Just some food for thought!

    Link to comment
    Share on other sites


    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate

  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Related Articles

    Scott Adams
    BMJ 2004;328:438-439 (21 February) Celiac.com 02/27/2004 – The following report is interesting, but I believe that serological studies done on those with schizophrenia would be a far better way to conduct such a study. Also, the use of such a small control group cannot accurately predict the actual incidence of schizophrenia in those with celiac disease. –Scott Adams
    According to a Danish study published in the British Medical Journal, people with celiac disease may have an increased risk of developing schizophrenia. Previous studies have also suggested an association between these two disorders. The study identified 7,997 people over age 15 who were admitted to a Danish psychiatric unit for the first time between 1981 and 1998 and were diagnosed with schizophrenia. The res...
    Scott Adams
    Acta Psychiatr Scand 2005: 1-9. C 2005 Blackwell Munksgaard. Celiac.com 02/09/2006 – After a review of the medical literature, researchers have concluded that many cases of schizophrenia are related to celiac disease or gluten intolerance, and can be successfully treated using a gluten-free diet. Like celiac disease, schizophrenia affects approximately 1% of the population. It is considered one of the top 10 causes of disability worldwide. In many studies the researchers found that in a subset of patients a drastic reduction or total elimination of schizophrenic symptoms occurred after they were treated with a strict gluten-free diet. Based on this the researchers believe that a gluten-free diet may serve as a "safe and economical alternative for the reduction of symptoms in a...
    Scott Adams
    American Journal of Psychiatry 163:521-528, March 2006
    Celiac.com 03/14/2006 – Danish researchers have found yet another link between celiac disease and schizophrenia. In a large epidemiologic study the researchers looked at 7,704 Danish people who were diagnosed with schizophrenia between 1981 and 1998, including their parents, and matched them to comparison control subjects. The data linkage required that the autoimmune disease be diagnosed before the diagnosis of schizophrenia. The researchers found that patients with a history of an autoimmune disease had a 45% increased risk for schizophrenia, and nine autoimmune disorders were indicators of a higher prevalence for schizophrenia when compared to the controls. The researchers conclude: “Schizophrenia is associated with a l...
    Jefferson Adams
    Celiac.com 04/29/2009 - A team of researchers based at UK's prospective University of Highlands and Islands (UHI) have found a link between gluten and schizophrenia. According to their latest findings, proteins found in the gluten of wheat, rye and barley might play a role in triggering schizophrenia in people with a genetic risk for the condition, or in worsening symptoms in people who have the disease.
    The research team has been looking into the role played by gluten in schizophrenia and diabetes, as well as hunting for connections between the two disorders. Their research showed that the bodies of certain schizophrenia sufferers could not properly processes gluten, which led to tissue damage.
    As a result of these and other findings, researchers now consider genetic risk...

  • Recent Activity

    1. knitty kitty
      - knitty kitty replied to Louise Broughton's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      4

      Louise

      @Louise Broughton, Some types of interferon drugs can precipitate a Thiamine deficiency, by destroying thiamine and blocking its absorption. Thiamine deficiency symptoms encompass all the symptoms you listed. Gastrointestinal Beriberi caused by Thiamine deficiency has symptoms of vomiting, bloating, abdominal pain and diarrhea. I've experienced this...
    2. knitty kitty
      - knitty kitty replied to Blue Roan's topic in Related Issues & Disorders
      1

      Lymph nodes in neck + thyroid issues

      Hi, @Blue Roan, I have Sjogren's Syndrome that made my salivary glands under my jaw swell. I also have dry eyes from Sjogren's. Yes, Sjogren's is yet another fun autoimmune disease that can occur in Celiac Disease. It starts in the salivary glands. Vitamin D deficiency can also make salivary glands swell. I was very deficient in Vitamin D also...
    3. cristiana
      - cristiana replied to MeghanEileenReilly's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      47

      Severe Itching And No Rash

      In my case I the rash and marks that present tend to be AFTER I have been scratching the skin, not before. There are several varieties of eczema. . https://www.aad.org/public/diseases/eczema/types A few years ago, I was convinced my son had ringworm. He had marks all over his torso, and given we live near livestock, I assumed he'd picked...
    4. knitty kitty
      - knitty kitty replied to MeghanEileenReilly's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      47

      Severe Itching And No Rash

      Are you scratching hard enough to leave bruising -- the dark marks? But no rash? And worse with exercise? And no flaking? I had vitamin deficiencies that caused neuropathy - itching, buzzing, tingling sensations, that I would scratch until I left bruising. Many of the B vitamins, if deficient, can cause this itchy feeling without a visible...
    5. SoBannaz
      - SoBannaz replied to MeghanEileenReilly's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      47

      Severe Itching And No Rash

      It’s interesting you mention eczema I had that as a child. Use to get it on my arms and hands . I wasn’t sure if this was the case again, because my skin isn’t flaky, I don’t have a rash like I did in childhood. But similarity I notice certain foods really triggers the itch. Rice, is a major tigger when I eat rice I end up itching all night long. I can ...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      125,661
    • Most Online (within 30 mins)
      7,748
    Tony690
    Newest Member
    Tony690
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.8k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Popular Now

    • Louise Broughton
      4
      Louise

      By Louise Broughton
      Started

    • sh00148
      19
      Vomiting - celiac or constipation

      By sh00148
      Started

    • pasqualeb
      9
      Muscle atrophy in legs

      By pasqualeb
      Started

    • Jean Shifrin
      14
      Severe joint swelling from Celiac

      By Jean Shifrin
      Started

  • Popular Articles

    • Scott Adams
      60
      The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free

      By Scott Adams

    • Scott Adams
      78
      Forbidden Gluten Food List (Unsafe Ingredients)

      By Scott Adams

    • Scott Adams
      66
      Safe Gluten-Free Food List (Safe Ingredients)

      By Scott Adams

    • Scott Adams
      144
      What Are the Symptoms of Celiac Disease?

      By Scott Adams

    • Scott Adams
      72
      Gluten-Free Alcoholic Beverages

      By Scott Adams

  • Upcoming Events

×
×
  • Create New...