Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

  • Record is Archived

    This article is now archived and is closed to further replies.

    Scott Adams
    Scott Adams

    By Scott Adams •

    Gluten-Sensitive Enteropathy in Patients with Insulin-Dependent Diabetes Mellitus

    Reviewed and edited by a celiac disease expert.

    Author: Rensch MJ; Merenich JA; Lieberman M; Long BD; Davis DR; McNally PR.
    Address: Fitzsimons Army Medical Center, Aurora, Colorado, USA.
    Source: Ann Intern Med, 124: 6, 1996 Mar 15, 564-7

    Celiac.com Sponsor (A12):
    OBJECTIVE: To determine the prevalence of celiac disease in a cohort of patients with insulin-dependent diabetes mellitus and to describe the clinical characteristics of patients with coexistent disease.

    DESIGN: Prospective cohort study.

    SETTING: U.S. Army medical center.

    PATIENTS: 47 patients with insulin-dependent diabetes mellitus.

    MEASUREMENTS: Antiendomysial antibody testing was used to screen for celiac disease. The diagnosis of celiac disease required histologic evidence of villous atrophy and crypt hyperplasia and a positive antiendomysial antibody test result. In patients identified as having coexistent disease, complete blood counts, multiphasic biochemical testing, D-xylose absorption testing, and bone mineral density estimates were done.

    RESULTS: 3 of 47 patients with insulin-dependent diabetes mellitus (6.4%; 95% CI, 1.4% to 17.5%) had positive antiendomysial antibody test results and small-bowel biopsy specimens consistent with celiac disease. The 95% CI lies entirely above the estimated prevalence of celiac disease expected in the general U.S. population, which ranges from 0.02% to 0.1%. Mean bone mineral densities were 0.8 and 1.1 SD below age-, ethnicity-, and sex-matched controls in each of the 2 antiendomysial antibody-positive patients tested. Small bowel absorption was abnormal in 1 of the 2 patients tested by D-xylose. Anemia and hypoalbuminemia were not detected in any of the patients with coexistent disease. Only 1 of the 3 patients had symptoms of diarrhea. All patients were at or above their ideal body weights.

    CONCLUSIONS: Celiac disease appears to be more common among patients with insulin-dependent diabetes mellitus than in the general U.S. population (p less than 0.001). Two of the three patients with coexistent disease in this study had sub-clinical or latent celiac disease.


     Share
    Go to articles

    User Feedback

    Recommended Comments

    Guest Scott

    Test Celiac is a very lonely, isolating disease. You turn down food at social gatherings, because when in doubt go without, and you suddenly become the obsessive freak about her food. It's up for the judges to prove plagiarism

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate

  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Related Articles

    Scott Adams
    Celiac.com 10/28/2004 - The following study demonstrates a connection between the length of time a celiac is exposed to gluten and the prevalence of anti-islet cell antibodies. This study supports many others that have shown that celiac patients are at high risk of developing insulin-dependent diabetes mellitus, which is a condition that has a long pre-diabetic period. It would be interesting to conduct a similar study on non-celiacs to determine if gluten has the same effect, which, if demonstrated, would mean that gluten has toxic, disease-causing properties in other people in addition to those with celiac disease.

    Rev Med Chil. 2004 Aug;132(8):979-84.
    BACKGROUND: Celiac patients are at high risk of developing insulin-dependent diabetes mellitus, a condition that...
    Jefferson Adams
    Celiac.com 09/24/2009 - Could a reduced level of antibodies against infectious agents indicate a protective role for such infections in T1DM development in susceptible individuals? Recent research points in that direction. Type 1 diabetes mellitus (T1DM) is an autoimmune disease with intricate and poorly understood associations between genetic and environmental factors.
    A joint Israeli-Colombian research team recently set out to examine the connections between anti-infectious antibodies and autoimmune-associated autoantibodies in patients with Type I diabetes mellitus and their close family members. Among other things, their findings confirmed a strong association between celiac disease and Type 1 diabetes mellitus.
    The research team was made up of Ilan Krause, Juan Manuel Anaya...
    Jefferson Adams
    Celiac.com 05/27/2013 - A team of researchers recently investigated whether celiac disease influences risk for non–insulin-dependent diabetes mellitus (NIDDM) and metabolic syndrome. To do so, they examined the prevalence of NIDDM and metabolic syndrome among adults with celiac disease, compared with healthy matched control subjects.
    The research team included Toufic A. Kabbani, Ciaran P. Kelly, Rebecca A. Betensky, Joshua Hansen, Kumar Pallav, Javier A. Villafuerte–Gálvez, Rohini Vanga, Rupa Mukherjee, Aileen Novero, Melinda Dennis, and Daniel A. Leffler.
    They are variously affiliated with the Celiac Center, Department of Medicine, Division of Gastroenterology at Beth Israel Deaconess Medical Center, and the Harvard School of Public Health in Boston, Massachusetts.
    ...

  • Recent Activity

    1. Wheatwacked
      - Wheatwacked replied to More2Learn's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      9

      Celiac Maybe a Possibility?

      Yeah, but that's probably not where you want to eat, anyway.
    2. BoiseNic
      - BoiseNic posted a topic in Dermatitis Herpetiformis
      0

      Skinesa

      Anyone try this? No matter what the brand, probiotics have ALWAYS made me break out bad. I am hesitant to try this simply for that fact, but I ordered a 3 month supply. Any input would be appreciated. Wish me luck.
    3. Wheatwacked
      - Wheatwacked replied to llisa's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Gluten free vitamins

      @llisa, I am curious to know how much vitamin D you are taking and what is your plasma level in nmol/L or ng/ml what the doctor's target 25(OH)D is. Hopefully with the gluten free diet you'll be able to feel better.
    4. trents
      - trents replied to llisa's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Gluten free vitamins

      Yes, but if you had been avoiding bread because of the stricture, that might explain the negative result of the previous celiac antibody test.
    5. llisa
      - llisa replied to llisa's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Gluten free vitamins

      Hashimoto diagnosed over 20 years ago after my daughter was diagnosed and told me to get checked due to similar symptoms. Diabetes diagnosed same time. Exocrine pancreatic insufficiency this past summer. Celiac last Wednesday. Have been having the digestive issues for a couple of years, several doctors--thought we had it solved with the Creon. Then symptoms...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      126,238
    • Most Online (within 30 mins)
      7,748
    Christi Brown
    Newest Member
    Christi Brown
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.3k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Popular Now

    • llisa
      20
      Gluten free vitamins

      By llisa
      Started

    • More2Learn
      9
      Celiac Maybe a Possibility?

      By More2Learn
      Started

    • CeliacChica
      45
      Muscle Twitching

      By CeliacChica
      Started

    • ellanataliw
      6
      Looking for a Pen Pal?

      By ellanataliw
      Started

  • Popular Articles

    • Scott Adams
      60
      The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free

      By Scott Adams

    • Scott Adams
      78
      Forbidden Gluten Food List (Unsafe Ingredients)

      By Scott Adams

    • Scott Adams
      66
      Safe Gluten-Free Food List (Safe Ingredients)

      By Scott Adams

    • Scott Adams
      144
      What Are the Symptoms of Celiac Disease?

      By Scott Adams

    • Scott Adams
      72
      Gluten-Free Alcoholic Beverages

      By Scott Adams

  • Upcoming Events

×
×
  • Create New...