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  • Jefferson Adams
    Jefferson Adams

    Gut Inflammation May Increase Risk for Parkinson’s Disease

    Reviewed and edited by a celiac disease expert.

    Parkinson's disease may manifest in the gastrointestinal tract may begin in the gut long before any motor symptoms show up. 

    Gut Inflammation May Increase Risk for Parkinson’s Disease - Image: CC BY 2.0--trendingtopics
    Caption: Image: CC BY 2.0--trendingtopics

    Celiac.com 12/02/2019 - Parkinson’s development can take many paths, with factors like genetics, aging, and environmental conditions all playing roles. Most people with Parkinson’s disease experience non-motor-symptoms, such as chronic constipation and/or impairment of gastrointestinal (GI) transit, long before the disease manifests clearly. Researcher Tomasza Brudek recently reviewed available medical literature for a possible link between Inflammatory Bowel Disease (IBD) and Parkinson's Disease.

    Brudek is affiliated with both the Research Laboratory for Stereology and Neuroscience, Copenhagen University Hospital, Bispebjerg-Frederiksberg Hospital in Copenhagen, Denmark; and the Copenhagen Center for Translational Research, Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital in Copenhagen, Denmark.

    Celiac.com Sponsor (A12):
    Build-up of α-synuclein protein in the form of Lewy bodies and Lewy neurites, and degeneration of substantia nigra dopamine neurons are classic clinical markers of Parkinson's Disease.

    Major features of Parkinson's Disease include inflammatory responses manifested by glial reactions, T cell infiltration, and increased expression of inflammatory cytokines, along with other toxic mediators derived from activated glial cells.

    Experimental, clinical and epidemiological data suggest that intestinal inflammation influences the development of Parkinson's Disease, while more and more studies suggest that Parkinson's disease may begin in the gut long before any motor symptoms show up.

    Patients with inflammatory bowel disease (IBD) have a higher risk of developing Parkinson's Disease compared with non-IBD individuals. Gene association study has found a genetic link between IBD and Parkinson's Disease, and an evidence from animal studies suggests that gut inflammation, similar to that observed in IBD, may induce loss of dopaminergic neurons.

    Based on preclinical models of Parkinson's Disease, some clinicians hypothesize that the early stages of early in Parkinson's Disease are marked by enteric microbiome changes, and gut infections triggering α-synuclein release and aggregation.

    Because gastrointestinal pathology can play such an important role in Parkinson's Disease development, there's good reason to believe that IBD and IBD treatments can influence Parkinson's Disease risk.

    This review underscores how important it is for physicians to be aware of Parkinson's Disease symptoms in IBD patients.

    Read more in the Journal of Parkinson's Disease, vol. 9, no. s2, pp. S331-S344, 2019



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    Jacqueline56

    This article scares me to death! I am an adopted. I was able to trace my family via DNA and found out alot about my grandmother and mother. Grandmother, in her 20s, died of malabsorption and so did her 4th baby. Also, her youngest child who I believe to be less than a year old. My mother and aunt survived. I don't know my mother's health issues except on her death certificate she had lung issues (smoking) and heart issues caused by Parkinson's. I now know why I have been sick for years, WHEAT/GLUTEN. I have also suffer several bouts of Candida and SIBO. I am, again, going gluten free to see if my health gets better. I am now scared that I am headed down the road to Parkinson's disease. Can anyone tell me the early signs/symptoms? 

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    cyclinglady
    2 hours ago, Jacqueline56 said:

    This article scares me to death! I am an adopted. I was able to trace my family via DNA and found out alot about my grandmother and mother. Grandmother, in her 20s, died of malabsorption and so did her 4th baby. Also, her youngest child who I believe to be less than a year old. My mother and aunt survived. I don't know my mother's health issues except on her death certificate she had lung issues (smoking) and heart issues caused by Parkinson's. I now know why I have been sick for years, WHEAT/GLUTEN. I have also suffer several bouts of Candida and SIBO. I am, again, going gluten free to see if my health gets better. I am now scared that I am headed down the road to Parkinson's disease. Can anyone tell me the early signs/symptoms? 

    Before you go gluten free, please ask your primary care physician to run a celiac disease blood test on you.  Going gluten free for a person with celiac disease is very hard.   Make sure you need to do so.  

    Just because you might have a genetic issue in your family, does not mean that you will get that disease.   35% of the population in the US has the genes that COULD turn into celiac disease, BUT only about 1 to 2% of those actually do.   Since you have Gastrointestinal issues, it would be a good idea to get tested.  

    The article was about Inflammatory Bowel Disease which includes Crohn’s and Ulcerative Colitis and not celiac disease.  People with IBD do not go gluten free as a general rule.  Try googling Parkinson’s since this is a celiac disease forum.  

    I think the article is pointing out that there MIGHT be a link between IBD and Parkinson’s.  So I would not panic.  I think it helps validate that many illnesses may start in the gut.  RESEARCHERS REALLY DO NOT KNOW.  

    Talk to your doctor.  ?

    Edited by cyclinglady
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    Jacqueline56
    57 minutes ago, cyclinglady said:

    Before you go gluten free, please ask your primary care physician to run a celiac disease blood test on you.  Going gluten free for a person with celiac disease is very hard.   Make sure you need to do so.  

    Just because you might have a genetic issue in your family, does not mean that you will get that disease.   35% of the population in the US has the genes that COULD turn into celiac disease, BUT only about 1 to 2% of those actually do.   Since you have Gastrointestinal issues, it would be a good idea to get tested.  

    The article was about Inflammatory Bowel Disease which includes Crohn’s and Ulcerative Colitis and not celiac disease.  People with IBD do not go gluten free as a general rule.  Try googling Parkinson’s since this is a celiac disease forum.  

    I think the article is pointing out that there MIGHT be a link between IBD and Parkinson’s.  So I would not panic.  I think it helps validate that many illnesses may start in the gut.  RESEARCHERS REALLY DO NOT KNOW.  

    Talk to your doctor.  ?

    No insurance, no doctor. I reached out to online doctor, told him my symptoms and he suggested, to help my symptoms, a gluten-free diet. I thought I had IBS, but other issues suggest wheat trouble. My mother's sister has 4 different digestive diseases and many surgeries to keep her alive. My middle son was born with malabsorption issues. He was 5 yrs before meds finally helped..he still suffers in his 40s. The diet has really helped my issues.

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    cyclinglady
    1 hour ago, Jacqueline56 said:

    No insurance, no doctor. I reached out to online doctor, told him my symptoms and he suggested, to help my symptoms, a gluten-free diet. I thought I had IBS, but other issues suggest wheat trouble. My mother's sister has 4 different digestive diseases and many surgeries to keep her alive. My middle son was born with malabsorption issues. He was 5 yrs before meds finally helped..he still suffers in his 40s. The diet has really helped my issues.

    Okay.  If you trial the diet, make sure you are really gluten free. Read through the forum for tips and advice like avoiding processed Foods and not eating out until you see results.  

    Good luck and I wish you well!  

    Edited by cyclinglady
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    Jacqueline56
    1 hour ago, cyclinglady said:

    Okay.  If you trial the diet, make sure you are really gluten free. Read through the forum for tips and advice like avoiding processed Foods and not eating out until you see results.  

    Good luck and I wish you well!  

    This will be my second time on gluten-free diet...I have cookbooks, recipes and most of the flour s I need to make fresh food. I am also, before this, changing my sugar to a better source. I bought a Nutribullet pro to make my morning smoothies with fresh fruits and vegs. My challenge is baking bread, so finding a recipe that I can handle is very important now...any suggestions?

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    cyclinglady
    13 hours ago, Jacqueline56 said:

    This will be my second time on gluten-free diet...I have cookbooks, recipes and most of the flour s I need to make fresh food. I am also, before this, changing my sugar to a better source. I bought a Nutribullet pro to make my morning smoothies with fresh fruits and vegs. My challenge is baking bread, so finding a recipe that I can handle is very important now...any suggestions?

    Please post your question under the food/recipe section of the forum.  You will get a better response.  ?

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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