12/06/2021 - Celiac disease is an auto-immune disease that can manifest in numerous ways. A team of researchers recently set out to assess rates of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially headache and migraine, and compare those to a healthy control group.
The team compared one thousand celiac subjects, with migraine and non-migrainous headache, registered at their celiac center, against a healthy control group, for headache parameters, in terms of GI and extra-intestinal symptoms.
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Overall, celiac subjects experienced higher rates of headache than control subjects, with the greatest prevalence in female celiacs. Celiac subjects also showed higher rates of migraine than controls, especially females. In fact 80% of females with celiac disease experienced migraine, and without aura nearly three-quarters of the time.
The most common GI symptoms in celiac subjects with headache were abdominal pain, diarrhea, and constipation, which were all more prevalent in celiac subjects with migraine. Conversely, celiac subjects with migraine saw lower rates of type 1 diabetes mellitus than celiac subjects with non-migrainous headache.
Multivariate logistic regression analysis showed that being female, and having celiac disease were independent predictors of headache, whereas patients over 60 years old saw some protective effects.
Celiac subjects have higher rates of headache, especially migraine, than healthy control subjects. Moreover, celiac subjects with migraine more commonly experience abdominal pain, diarrhea, and constipation than celiac subjects with non-migrainous headaches.
Because of this, the team recommends celiac screening for patients with migraine and simultaneous GI symptoms.
Read more at PLOS ONE
The research team included Mohammad M. Fanaeian, Nazanin Alibeik, Azita Ganji, Hafez Fakheri, Golnaz Ekhlasi, and Bijan Shahbazkhani. They are variously affiliated with the Division of Gastroenterology and Liver Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences inTehran, Iran; the Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran; the Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashahd, Iran; the Gut and Liver Research Center, Non-communicable Disease Institue at Mazandaran University of Medical Sciences in Sari, Iran; and the Digestive Disease Research Institute at Shariati Hospital, Tehran University of Medical Sciences in Tehran, Iran.
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