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    Higher Rates of Headache and Migraine in Adults with Celiac Disease

    Reviewed and edited by a celiac disease expert.

    Adults with celiac disease have higher rates of mheadache and migraine that healthy control subjects.

    Higher Rates of Headache and Migraine in Adults with Celiac Disease - Image: CC BY 2.0--Unlisted Sightings
    Caption: Image: CC BY 2.0--Unlisted Sightings

    12/06/2021 - Celiac disease is an auto-immune disease that can manifest in numerous ways. A team of researchers recently set out to assess rates of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially headache and migraine, and compare those to a healthy control group.

    The team compared one thousand celiac subjects, with migraine and non-migrainous headache, registered at their celiac center, against a healthy control group, for headache parameters, in terms of GI and extra-intestinal symptoms.

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    Overall, celiac subjects experienced higher rates of headache than control subjects, with the greatest prevalence in female celiacs. Celiac subjects also showed higher rates of migraine than controls, especially females. In fact 80% of females with celiac disease experienced migraine, and without aura nearly three-quarters of the time. 

    The most common GI symptoms in celiac subjects with headache were abdominal pain, diarrhea, and constipation, which were all more prevalent in celiac subjects with migraine. Conversely, celiac subjects with migraine saw lower rates of type 1 diabetes mellitus than celiac subjects with non-migrainous headache. 

    Multivariate logistic regression analysis showed that being female, and having celiac disease were independent predictors of headache, whereas patients over 60 years old saw some protective effects.

    Celiac subjects have higher rates of headache, especially migraine, than healthy control subjects. Moreover, celiac subjects with migraine more commonly experience abdominal pain, diarrhea, and constipation than celiac subjects with non-migrainous headaches. 

    Because of this, the team recommends celiac screening for patients with migraine and simultaneous GI symptoms.

    Read more at PLOS ONE

     

    The research team included Mohammad M. Fanaeian, Nazanin Alibeik, Azita Ganji, Hafez Fakheri, Golnaz Ekhlasi, and Bijan Shahbazkhani. They are variously affiliated with the Division of Gastroenterology and Liver Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences inTehran, Iran; the Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran; the Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashahd, Iran; the Gut and Liver Research Center, Non-communicable Disease Institue at Mazandaran University of Medical Sciences in Sari, Iran; and the Digestive Disease Research Institute at Shariati Hospital, Tehran University of Medical Sciences in Tehran, Iran.



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    NCMtnMomma

    I was diagnosed w/celiac in 2008. I had no symptoms other than joint pain & gas. I am a female, age 75. My digestive problems started after diagnosis. The usual, diarrhea & gas. I rarely ever get headaches & never had a migraine.  I'm just weird.  I also have Hashimotos. No symptoms there either, it just showed up in annual bloodwork. My doctor said I had thyroid problems & I take  levothyroxine.  I had to ask for a specific test for Hashimotos because I wanted to know if it was autoimmune & it is  I am very strict with my gluten free diet.  I never ever cheat. I have experienced cross contamination over the years (not fun).  Now I rarely eat out, maybe 2 or 3 times a year.  I have found a digestive supplement that is enzymes & all natural & have been taking it for about 3 months.  It does 'not' cure celiac, but my  symptoms have improved about 97%.  The results were almost immediate.  It works better than fiber supplements & I feel like it has definitely improved my quality of life.  I won't name the product, it is only available by mail.  I feel almost normal.  

     

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    Guest Flav

    Most of my life i had migraines. In 2011 (age 31) at its worst, i was literally having 20-25 migraines a month. I was at the point where advil and excedrin did nothing to relieve the pain. I went gluten free in march 2012 and within a month my headaches stopped. Now i get a headache once a month or every other month. 

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    LindaD24

    I was diagnosed with Celiac in 1997, up until then I suffered with intense migraines about once a month and headaches.  I had started taking Triptans for the migraines in 1992.  However, I hoped that once I was menopaused, the migraines would stop.  They just became increasingly worse.....14, 15, 16 per month.   I am currently under the care of a Neurologist and receiving Botox injections to help prevent migraine.  

    I eat a gluten free diet and stick to it....yes, there are times I eat in a restaurant and there is a possibility of cross contamination.  

    I have been wondering if there had been any connection between Celiac Disease and migraine.   This article helped.  Thank you.

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    trents
    2 hours ago, LindaD24 said:

    I was diagnosed with Celiac in 1997, up until then I suffered with intense migraines about once a month and headaches.  I had started taking Triptans for the migraines in 1992.  However, I hoped that once I was menopaused, the migraines would stop.  They just became increasingly worse.....14, 15, 16 per month.   I am currently under the care of a Neurologist and receiving Botox injections to help prevent migraine.  

    I eat a gluten free diet and stick to it....yes, there are times I eat in a restaurant and there is a possibility of cross contamination.  

    I have been wondering if there had been any connection between Celiac Disease and migraine.   This article helped.  Thank you.

    My physician put me on 25mg daily of nortriptyline and it seems to have dramatically cut down the frequency of my migraines. I have had 2-3 migraines in about a three month period as opposed to several a week before. I am still with holding final judgement, however, because mine are somewhat seasonal.

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    Guest Samenk

    I had migraines for many years and was given typical med with only 9 pills a month allowed. It helped but didn’t prevent future headaches. Finally I omitted dairy from my diet and had almost immediate results. Now I only get an occasional mild headache, usually weather related. I find omitting dairy harder than gluten, however I’ve strictly followed a gluten-free diet for 35 years. It’s very worth trying!  
     

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    Scott Adams
    4 hours ago, LindaD24 said:

    I was diagnosed with Celiac in 1997, up until then I suffered with intense migraines about once a month and headaches.  I had started taking Triptans for the migraines in 1992.  However, I hoped that once I was menopaused, the migraines would stop.  They just became increasingly worse.....14, 15, 16 per month.   I am currently under the care of a Neurologist and receiving Botox injections to help prevent migraine.  

    I eat a gluten free diet and stick to it....yes, there are times I eat in a restaurant and there is a possibility of cross contamination.  

    I have been wondering if there had been any connection between Celiac Disease and migraine.   This article helped.  Thank you.

    There is a strong connection between migraines and untreated celiac disease, and we have summarized much of the medical research on this topic in the category below:

    https://www.celiac.com/celiac-disease/celiac-disease-amp-related-diseases-and-disorders/migraine-headaches-and-celiac-disease/

    Eating out could definitely be a source of cross-contamination, so you may want to look again at your diet to see if you may be getting contamination on a regular basis. Doing another celiac disease blood panel screening may show that your antibody levels are high again, so it may be worth doing that to find out.

    This article has some detailed information on how to be 100% gluten-free, so it may be helpful:

     

     

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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