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  • Jefferson Adams
    Jefferson Adams

    How Promising is Gliadin Sequestration as a Therapy for Celiac Disease?

    Reviewed and edited by a celiac disease expert.

    Can gliadin sequestration therapy lead to new celiac therapies?

    How Promising is Gliadin Sequestration as a Therapy for Celiac Disease? - Armor protection. Image: CC BY 2.0--mark6mauno
    Caption: Armor protection. Image: CC BY 2.0--mark6mauno

    Celiac.com 10/25/2021 - Celiac disease is an autoimmune disorder marked by a strong immune response to dietary gluten proteins, which causes gastrointestinal symptoms, and damages the small intestine. Despite being fairly common, the only current treatment for celiac disease is a strict gluten-free diet. 

    A number of clinical trials have looked to impede or reduce the immune response, many by targeting gluten proteins via immunosuppression, enhanced protein degradation or protein sequestration. 

    Celiac.com Sponsor (A12):
    Some data indicates that polyphenols may provide protection from celiac disease damage by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis, and driving a reduction in inflammation. 

    Researchers Charlene B. Van Buiten, and Ryan J. Elias recently set out to review mechanisms by which polyphenols can protect against celiac disease, critically assess recent works, and sketch out future applications for using polyphenols to protect against celiac disease.

    Van Buiten and Elias are affiliated with the Department of Food Science and Human Nutrition, College of Health and Human Sciences, Colorado State University, Fort Collins, Colorado, and the Department of Food Science, College of Agricultural Sciences, Pennsylvania State University, University Park, Pennsylvania.

    Their review highlights ways in which polyphenols can protect against celiac disease, offers a critical assessment of recent studies, and sketches potential applications for treating celiac disease in this manner.

    Their review appears in the International Journal of Molecular Science.

    Read more in Int. J. Mol. Sci. 2021, 22(2), 595
     



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    olajuwon.okubena

    This is a very beautiful article on polyphenols and celiac disease. I will like to know if you have any information about polyphenols from Sorghum bicolor and how it can help in improving the health of people with celiac disease. 

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    Scott Adams

    We've not seen a research article on that topic, but if there is one available we'd be interested in it. This is the source of this article: Open Original Shared Link

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    Distressed

    Encouraging article, but my gut has worsened recently.  Can not eat anything except plain meat and well cooked vegetables.  Nothing else.  It's strange and frightening. The only side benefit has been weight loss. 

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    Guest Janet
    47 minutes ago, Distressed said:

    Encouraging article, but my gut has worsened recently.  Can not eat anything except plain meat and well cooked vegetables.  Nothing else.  It's strange and frightening. The only side benefit has been weight loss. 

    Are you using gluten-free lipstick, chapstick, lotion, cleaning products, deoderant, make up, hair products and anything else you bring into your home?  I have heard people say "why do I need all these things to be gluten-free?"  Because you  get these things on your hands, touch your face or mouth without even realizing it and get gluten in your mouth. gluten-free lip products are especially important  (Eos lip balms and body lotions are all gluten-free  They even have colored lip balm .)

    A great place to search ingrdients in non-food products is "skin safe". It lists all ingredients that are contained in thousands of products. Also "very well fit" is a place to search whether products have gluten.   My 16 year old daughter was diagnosed with celiacs  seven months ago and uses these sites.  Her blood work after six months gluten-free showed no antibodies for gluten so that makes me think we can trust these sites for keeping her gluten-free 

    Hope this helps. Good luck to everyone. 

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    Mrs.Sikes
    On 10/26/2021 at 1:45 PM, Scott Adams said:

    We've not seen a research article on that topic, but if there is one available we'd be interested in it. This is the source of this article: Open Original Shared Link

    I agree with you, unfortunately I am gaining weight and I’m devastated. I’m not a big meat eater so it makes it very hard to get enough protein.  Geez my choices are next to nothing now so you would think I would not be able to gain weight. 

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    Distressed
    1 hour ago, Mrs.Sikes said:

    I agree with you, unfortunately I am gaining weight and I’m devastated. I’m not a big meat eater so it makes it very hard to get enough protein.  Geez my choices are next to nothing now so you would think I would not be able to gain weight. 

    Calcium Deficiency: A Cause of Obesity? | (robertbarrington.net).  Back in 2009, I had 4 bowel movements after each meal.  Never lost weight during that time and my calcium serum levels rose.  Peripheral neuropathy and eventually hyperparathyroidism with many neurological problems.  After surgery, calcium was a daily requirement.  I reacted poorly to the D3 contained in the supplement (confusion & joint pain).  I switched to one that contained calcium, mag & zinc.  Recently I tried a Di-calcium malate and Di-Magnesium malate.  Strangely, my thyroid function improved and the dosage of medication was reduced. 

    7 weeks ago: I was doing well until my SO had a quad-flu shot.  It has a powerful adjunct this year. The man who never gets a reaction to vaccines had the expected S&S of reaction the first day. Day 2, respiratory manifestations was the start of the full-blown SARS/MERS disease.  He was not around others & the pharmacy aide wore a mask.  I had not been in contact with anyone other than him for 7 days prior to this.  Day 4 and I began with: respiratory & gastrointestinal manifestations on top of every symptom. Diarrhea for over 3 weeks.  It began to slow down and then I made a grave error.  Bought food item with phosphates & then a feta that contained cellulose to prevent caking & a fungicide. Preservatives & cellulose = diarrhea.  Still having bowel issues.  The last 7 weeks have been a "major" set-back.  I'm "married" to the toilet bowl.  So upset at having a "leaky" gut.  Thank you for sharing and life is super tough with celiac.

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    Wheatwacked
    1 hour ago, Mrs.Sikes said:

    I’m not a big meat eater so it makes it very hard to get enough protein.

    A cup, 6 ounces, of pinto beans, small red beans and chick peas (better mouth feel combined) has 45 grams of protein (75%RDA), 125% rda of fiber, 130% iron, 120 % phosphorus, 53% potassium, 300% folate, only 7 grams of fat. 814 calories.  Soak overnight, rinse, bring to a boil then simmer an hour and rinse and drain. Cooked weight is just over double dry weight. Add two jumbo hard boiled eggs (130 grams) and you have 100% RDA protein and 91% choline at only 988 calories. Salt to taste because without adding salt the Sodium to Potassium ratio is 1:10

    Quote

    Our Paleolithic hunter-gatherer ancestors took in about 11,000 milligrams (mg) of potassium a day from fruits, vegetables, leaves, flowers, roots, and other plant sources, and well under 700 mg of sodium. That's a sodium-to-potassium ratio of 1 to 16.   Open Original Shared Link

    "The ideal ratio of sodium to potassium intake is roughly 1:3 — that is, potassium intake would ideally be around three times our sodium intake.   Open Original Shared Link

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    Mrs.Sikes
    1 hour ago, Distressed said:

    Calcium Deficiency: A Cause of Obesity? | (robertbarrington.net).  Back in 2009, I had 4 bowel movements after each meal.  Never lost weight during that time and my calcium serum levels rose.  Peripheral neuropathy and eventually hyperparathyroidism with many neurological problems.  After surgery, calcium was a daily requirement.  I reacted poorly to the D3 contained in the supplement (confusion & joint pain).  I switched to one that contained calcium, mag & zinc.  Recently I tried a Di-calcium malate and Di-Magnesium malate.  Strangely, my thyroid function improved and the dosage of medication was reduced. 

    7 weeks ago: I was doing well until my SO had a quad-flu shot.  It has a powerful adjunct this year. The man who never gets a reaction to vaccines had the expected S&S of reaction the first day. Day 2, respiratory manifestations was the start of the full-blown SARS/MERS disease.  He was not around others & the pharmacy aide wore a mask.  I had not been in contact with anyone other than him for 7 days prior to this.  Day 4 and I began with: respiratory & gastrointestinal manifestations on top of every symptom. Diarrhea for over 3 weeks.  It began to slow down and then I made a grave error.  Bought food item with phosphates & then a feta that contained cellulose to prevent caking & a fungicide. Preservatives & cellulose = diarrhea.  Still having bowel issues.  The last 7 weeks have been a "major" set-back.  I'm "married" to the toilet bowl.  So upset at having a "leaky" gut.  Thank you for sharing and life is super tough with celiac.

    Wow I am so sorry. Sometimes we think we have it bad until we hear another’s woes.  Hanging in there how you have a bidet. Paper products are no bueno. Thank you for sharing your struggles.

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    AmyMcHenry
    On 11/4/2021 at 3:39 PM, Mrs.Sikes said:

    I agree with you, unfortunately I am gaining weight and I’m devastated. I’m not a big meat eater so it makes it very hard to get enough protein.  Geez my choices are next to nothing now so you would think I would not be able to gain weight. 

    My story!!!!

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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