Celiac.com 10/25/2021 - Celiac disease is an autoimmune disorder marked by a strong immune response to dietary gluten proteins, which causes gastrointestinal symptoms, and damages the small intestine. Despite being fairly common, the only current treatment for celiac disease is a strict gluten-free diet.
A number of clinical trials have looked to impede or reduce the immune response, many by targeting gluten proteins via immunosuppression, enhanced protein degradation or protein sequestration.
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Some data indicates that polyphenols may provide protection from celiac disease damage by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis, and driving a reduction in inflammation.
Researchers Charlene B. Van Buiten, and Ryan J. Elias recently set out to review mechanisms by which polyphenols can protect against celiac disease, critically assess recent works, and sketch out future applications for using polyphenols to protect against celiac disease.
Van Buiten and Elias are affiliated with the Department of Food Science and Human Nutrition, College of Health and Human Sciences, Colorado State University, Fort Collins, Colorado, and the Department of Food Science, College of Agricultural Sciences, Pennsylvania State University, University Park, Pennsylvania.
Their review highlights ways in which polyphenols can protect against celiac disease, offers a critical assessment of recent studies, and sketches potential applications for treating celiac disease in this manner.
Their review appears in the International Journal of Molecular Science.
Read more in Int. J. Mol. Sci. 2021, 22(2), 595
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