How Solid is the Evidence for Non-celiac Gluten Sensitivity?

First off to test positive for Gluten you must be on a full regiment of gluten foods when tested. And yes, there is such a thing as having the same symptoms when you do not test positive. In fact, these individuals are more sensitive that the ones who test positive. Because most of these people cannot even eat gluten free food.

This study does not take a position on whether or not there might be a condition called non-celiac gluten sensitivity. Nor does the study negate the possibility that some people with celiac-like symptoms fail to test positive for anti-gliadin antibodies. The study merely describes the lack of evidence to support NCGS in double-blind studies. Could it still be a thing? Sure. Does the clinical evidence support it? Not in this study. Another serious problem, as pointed out by the study is the fact that 40% of patients routinely report celiac-like symptoms after receiving a placebo. This indicates either a psycho-somatic aspect to these symptoms, or possibly an unknown sensitivity. Either way, many questions need to be answered before we will have a solid scientific answer.

First off to test positive for Gluten you must be on a full regiment of gluten foods when tested. And yes, there is such a thing as having the same symptoms when you do not test positive. In fact, these individuals are more sensitive that the ones who test positive. Because most of these people cannot even eat gluten free food.

So true...I got tested many times for gluten sensibility and already got most of the tests available on the market (endoscopy,colonoscopy, barium, igA,igG) all with negative results. (except for early stage of Hashimoto (not confirmed by doctor yet) and probably IBS , but the doctor told me that she is not sure of right diagnosis, polycystic ovary, zero vitamin D, candida and pylori) anyway the gluten free product hurt my stomach more than the gluten. I can consume gluten for a week or two before my stomach gets upset, headaches and I start to get rash or eczema on my skin but it takes me a few gluten free cookies (2-3) to get upset stomach. At some point the doctor tell me is all stress and psychological problems.

This study does not take a position on whether or not there might be a condition called non-celiac gluten sensitivity. Nor does the study negate the possibility that some people with celiac-like symptoms fail to test positive for anti-gliadin antibodies. The study merely describes the lack of evidence to support NCGS in double-blind studies. Could it still be a thing? Sure. Does the clinical evidence support it? Not in this study. Another serious problem, as pointed out by the study is the fact that 40% of patients routinely report celiac-like symptoms after receiving a placebo. This indicates either a psycho-somatic aspect to these symptoms, or possibly an unknown sensitivity. Either way, many questions need to be answered before we will have a solid scientific answer.

Can it be possible that other genes cause this problem which are not yes discovered? It looks to me that there are not that many serious studies of non celiac gluten sensibility or possibly this can be connected to other autoimmune problems. There must be some connection that have been missing in the studies? Maybe there is something more than gluten that affects the autoimmune system and triggers all the problems?

On 8/29/2017 at 10:35 PM, Guest aileen said:

Can it be possible that other genes cause this problem which are not yes discovered? It looks to me that there are not that many serious studies of non celiac gluten sensibility or possibly this can be connected to other autoimmune problems. There must be some connection that have been missing in the studies? Maybe there is something more than gluten that affects the autoimmune system and triggers all the problems?