Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • John B. Symes, D.V.M.
    John B. Symes, D.V.M.

    Lectins Meet Livers at the Fat Chance Saloon

    Reviewed and edited by a celiac disease expert.

    Journal of Gluten Sensitivity Spring 2007 Issue. NOTE: This article is from a back issue of our popular subscription-only paper newsletter. Some content may be outdated.

    Lectins Meet Livers at the Fat Chance Saloon - Image: CC BY 2.0--Boston Public Library
    Caption: Image: CC BY 2.0--Boston Public Library

    Celiac.com 08/11/2021 - It takes a well-trained CIA operative to decipher some of this stuff.  If the consumption of fat is thought to contribute to fatty liver (which it doesn’t), then why is it found in the context of starvation?  Why is alcoholism the leading cause of fatty liver disease in people?  And why does gastric bypass surgery, which involves a dramatic reduction in calories, trigger fatty liver disease?  This same surgery is also associated with the precipitous development of iron deficiency anemia, bone density issues (osteoporosis) and immune failure in many cases.  The morbidity rate following this harmful surgical invention is staggeringly high, and totally explainable.  They’re making acute surgical celiacs out of these people.  The symptoms they show could be the direct result of malabsorption of vital nutrients that would normally be picked up by the duodenum (calcium, iron, iodine, B complex, vitamin C, and trace minerals).  This kind of physiological stress could trigger just about anything, including a subclinical viral infection (or viral adaptation) of the liver.

    But why do I get so upset over seemingly insignificant news items claiming that fatty liver disease is the result of eating fat?  Because the low fat diet is one of man’s worst dietary inventions!  Fat is crucial to a healthy diet, serving as a vehicle for certain vitamins to enter our body (the fat soluble A,D,E,K) the source of essential fatty acids (omegas), and the provider of protection against things trying to affect and invade our body, including these pesky lectins I keep writing so much about.  Yes, dietary fat (animal fat not man-made trans fats) helps to block the attachment of certain dietary glycoproteins (e.g.  the harmful ones from gluten, dairy, soy, etc.) to the villi of our intestinal tract.  Other things that help in this regard are good carbs and glycoproteins from fruits and veggies such as pectin from apples.  Pectins actually bind lectins.  Fats more or less coat the GI tract and prevent the attachment of lectins.  That is why whole milk is less harmful than skim milk, as I have discussed before.  

    Celiac.com Sponsor (A12):
    About five years ago I started seeing more and more chicken allergies in dogs.  I wondered if it was because dogs were eating more chicken and that it was a secondary food allergen due to the damage being done by the “big 4” (gluten, casein, soy, and corn) like so many other food allergies, or whether there was something in the chicken that was inducing the problems.  

    I decided to check out what they were feeding poultry on the hunch that they were loading them up with gluten grains and corn.  Five minutes into an Internet search yielded my answer.  As of about 10 years ago now, they have been pouring the wheat to chickens and turkeys.  If they fed them too much wheat, do you know what happened?  They died of fatty liver syndrome.  Until now, fatty liver syndrome has been considered “idiopathic: in veterinary medicine.  Cats die from fatty liver syndrome.  Fatty liver disease is the leading cause of liver disease and failure in the cat.  

    And what is the leading cause of fatty liver disease in people?  Alcohol—grain alcohol.  Most alcohols are made from grains, including beer.  Could it really be the lectins in the grains that are inducing the fatty liver disease more than the alcohol itself?  That makes sense when you think about the number of people who drink (excessively) versus the number who develop fatty liver disease.  There has to be something special about those people.  Either they have gluten sensitivity or a resident virus or both.

    We are making great strides in expanding our understanding of lectins (e.g.  those in the “big four”, legumes, grains, corn and dairy), environmental pollutants, trans fats, and the damage done by some drugs.  Celiac awareness has opened a number of doors and will lead to improved understanding of dairy, soy and corn intolerance as well.  I can’t wait for cow milk to finally be publicly convicted for what it has done to human and veterinary health.  That time is coming soon.  

    We have had this wrong for years and the evidence has pointed us in a better direction for a number of years as well.  Fat is not the enemy.  You don’t get fat from eating fat.  Dr. Atkin’s helped prove this.  Similarly, your cholesterol does not go up primarily from eating dietary cholesterol.  Further, an unusually low cholesterol diet is not healthful.  Cholesterol, for example, is the building block for all of our hormones, including sex hormones and cortisones.  It is an essential component in immune responses and in the protection of individual cells from invasion by harmful substances and organisms.  The anti-cholesterol and anti-fat campaigns are ill-conceived, misguided, and harmful to our health, thus my passion on this topic.  



    User Feedback

    Recommended Comments

    Wheatwacked

    Deficient choline ingestion/absortion. AI for choline, male adult is 550 mg. Average male intake is only 402 mg. It was finally recognized as an essential in 1998, while investigating the cause of non-alcoholic fatty liver in complete parenteral patients. Demand for it rises in cases of folate malabsorption such as celiac and alcoholism, or insufficient intake.  

    Quote

    Choline also plays important roles in modulating gene expression, cell membrane signaling, lipid transport and metabolism, and early brain development ...the amount that the body naturally synthesizes is not sufficient to meet human needs...When a diet is deficient in folate, a B-vitamin that is also a methyl donor, the need for dietary choline rises because choline becomes the primary methyl donor...Plasma choline levels do not decline below 50% of normal, even in individuals who have not eaten for more than a week [3]. This may be due to the hydrolysis of membrane phospholipids, a source of choline, to maintain plasma choline concentrations above this minimal level...the average daily choline intake from foods and beverages is 402 mg in men and 278 mg in women.  Open Original Shared Link

     

    Link to comment
    Share on other sites


    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    John B. Symes, D.V.M.

    John B. Symes, AKA “DogtorJ”, DVM is a veterinarian who has been practicing veterinary medicine for over twenty-five years.  He graduated with honors from Auburn University in 1979 and followed that with an internship at the prestigious Angell Memorial Animal Hospital in Boston. 
     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Betty Wedman-St Louis, PhD, RD
    Lectins Are Toxins
    Celiac.com 12/01/2015 - Lectins are carbohydrate binding proteins which promote inflammatory responses like Crohn's disease, systemic lupus, asthma, and rheumatoid arthritis. They were discovered over 100 years ago and cause leaky gut and gastrointestinal dysbiosis yet the push for a plant-based diet focusing on legumes as meat alternatives has overlooked the damage lectins cause to the gut. Legumes offer inferior nutrition compared to animal proteins so toxicity needs to be considered when recommending food choices.
    As carbohydrate binding proteins, lectins are difficult to digest and irritate the brush border of the small intestine. Consequently, the tight junctions of the microvilli are damaged by prolamin and agglutinins which can lead to numerous disorders of the gastrointestinal...


    Sayer Ji
    Wheat Germ Lectin: Opening Pandora’s Bread Box
    Celiac.com 11/02/2019 - Now that celiac disease has been allowed official entry into the pantheon of established medical conditions, and gluten intolerance is no longer entirely a fringe medical concept, the time has come to draw attention to the powerful little chemical in wheat known as ‘wheat germ agglutinin’ (WGA) which is largely responsible for many of wheat’s pervasive, and difficult to diagnose, ill effects.  Not only does WGA throw a monkey wrench into our assumptions about the primary causes of wheat intolerance, but due to the fact that WGA is found in highest concentrations in “whole wheat,” including its supposedly superior sprouted form, it also pulls the rug out from under one of the health food industry’s favorite poster children.  
    Below the radar of conventional ...


    Scott Adams
    What Can Topographic Lectin Mapping Reveal About Celiac Disease?
    Celiac.com 04/07/2020 - In the past few years, clinicians have begun to use of specific sugar residue seeking dietary proteins, called lectins, to topographically map the small intestinal cell surface and goblet cell secretory mucins to reveal the tissue's structure and function. Better understanding of the gut microbiome may be crucial to discovering the origins and modes of development of celiac disease and other sprue-like intestinal disorders.
    Researcher Hugh James Freeman of the Department of Medicine, Gastroenterology, at the University of British Columbia, Vancouver, BC, Canada recently set out to examine the relationship between topographic lectin mapping of the epithelial cell surface in normal intestine and celiac disease.
    Researchers are still in the dark about th...


    John B. Symes, D.V.M.
    Lectins Explain So Much
    Celiac.com 05/28/2021 - In my search for medical answers, the study of lectins did explain so much.  (e.g. The “Lectin Report. Once we see that these harmful glycoproteins, especially those from gluten, dairy, soy and corn, can cause tissue damage/inflammation all by themselves, without an immune response, things really start making sense. The immune response is secondary to that damage, which helps to explain why we see such variation in the measurable response by different individuals. Some will respond with an outpouring of antibodies yielding positive tests while others will not, thus helping to explain the negative tests in individuals who end up responding quite well to the elimination diet when employ it despite those negative tests. 
    These dietary glycoproteins are also a b...


  • Recent Activity

    1. - knitty kitty replied to TerryinCO's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      9

      New Guy Here...

    2. - ellyelly replied to ellyelly's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      4

      Biopsy results - second opinion?

    3. - RonMc replied to Itchyperson's topic in Dermatitis Herpetiformis
      30

      Cycle of dermatitis herpetiformis

    4. - TerryinCO replied to TerryinCO's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      9

      New Guy Here...

    5. - knitty kitty replied to ellyelly's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      4

      Biopsy results - second opinion?


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      127,240
    • Most Online (within 30 mins)
      7,748

    Eilidh Aitchison
    Newest Member
    Eilidh Aitchison
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • ellyelly
      4
    • trsprecker
    • TerryinCO
      9
    • joleenrae
    • AndiOgris
      5
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...