Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    Malignant Cancers are a Hidden Danger for Celiacs

    Reviewed and edited by a celiac disease expert.

    A new study shows a high danger of malignancy in celiac patients.

    Malignant Cancers are a Hidden Danger for Celiacs - Image: CC BY-SA 2.0--Thomas Berg
    Caption: Image: CC BY-SA 2.0--Thomas Berg

    Celiac.com 05/01/2023 - Celiac disease is a condition that affects millions of people worldwide. Celiac disease is an immune-mediated enteropathy triggered by gluten, a protein found in wheat and related grains. For people with celiac disease, eating gluten can lead to a range of symptoms and damage to the small intestine. 

    The only effective treatment for the disease is a strict gluten-free diet, which allows the intestines to heal and prevents further complications. However, recent research has shed light on the potential dangers of having celiac disease: the danger of malignant complications.

    Celiac.com Sponsor (A12):
    A group of researchers at the Department of Internal Medicine and Gastroenterology, University Hospital Brno, recently conducted a study examining the occurrence of malignancies in patients with celiac disease. They wanted to raise awareness of these potentially life-threatening complications, with the hope of promoting earlier diagnoses and better outcomes.

    Occurrence of Malignancies in Patients with Celiac Disease

    The study analyzed seven cases of malignancies that occurred among 190 celiac disease patients over a seven-year period. The patients ranged in age from 36 to 82 years old, with a mix of men and women. The malignancies found by the team included small bowel adenocarcinoma, diffuse large B-cell lymphoma, carcinoma of the tongue, and colorectal carcinoma.

    The overall findings were alarming, as malignancies were present in nearly 4% of the patients in the study. This highlights the need for better awareness of the potential risks associated with celiac disease. 

    Professionals Need to Work Towards Earlier Diagnoses

    By understanding the risk factors, recognizing the presentation of malignant complications, and closely monitoring the disease course, healthcare professionals can work towards earlier diagnoses and better outcomes for patients.

    The study also emphasized the importance of continued research into potential risk factors for malignancies in celiac disease patients. Identifying these factors could help in developing strategies for prevention and early intervention.

    For people living with celiac disease, this research underscores the need for regular check-ups and close monitoring of their condition. It's really important for patients to maintain a strict gluten-free diet, as this remains the only real way for celiacs to stay as healthy as possible. By doing so, celiacs can reduce their risk of complications and improve their overall quality of life.

    Read more in Journal of Medical Case Reports



    User Feedback

    Recommended Comments



    LP023
    3 hours ago, trents said:

    I don't know. Depriving one's self of gluten free comfort foods may create anxiety that does more harm than the comfort food.

    That’s just me. It’s full of junk. I wasn’t much of a carb eater to begin with so the diet has been easy for me. My biggest worries come from accidentally getting it.  Knowing the link between celiacs and diabetes I just stay away from it. If someone needs it to feel   better mentally I say go for it. 

    Link to comment
    Share on other sites
    cristiana
    7 hours ago, trents said:

    I don't know. Depriving one's self of gluten free comfort foods may create anxiety that does more harm than the comfort food.

    I sympathise with this, coming from England where afternoon tea has been a big part of our family's traditions!

    I have managed to reduce my sugar consumption from time to time but I find it hard to give up totally, partly because I have a sweet tooth (nature or nurture, who knows?!) but also as a coeliac often the only food available at a cafe or restaurant which has been made in a guaranteed gluten free facility is a pre-packed cake or cookie.  So while everyone else is eating their food, at least I can order a coffee and a gluten-free brownie.

    I love being able to eat something when I go out that I know is safe, and if all there is is something sweet, I'll eat it.  I know people will say to me they are never glutened if they order a jacket potato and salad, but I've been glutened several times by eating just that, including last week.  I eat out rarely, but there is one chef I can trust at a local pub.  Turns out both time I've been glutened there she was off duty!  

     

    Edited by cristiana
    Link to comment
    Share on other sites
    LP023
    9 hours ago, cristiana said:

    I sympathise with this, coming from England where afternoon tea has been a big part of our family's traditions!

    I have managed to reduce my sugar consumption from time to time but I find it hard to give up totally, partly because I have a sweet tooth (nature or nurture, who knows?!) but also as a coeliac often the only food available at a cafe or restaurant which has been made in a guaranteed gluten free facility is a pre-packed cake or cookie.  So while everyone else is eating their food, at least I can order a coffee and a gluten-free brownie.

    I love being able to eat something when I go out that I know is safe, and if all there is is something sweet, I'll eat it.  I know people will say to me they are never glutened if they order a jacket potato and salad, but I've been glutened several times by eating just that, including last week.  I eat out rarely, but there is one chef I can trust at a local pub.  Turns out both time I've been glutened there she was off duty!  

     

    It’s perfectly fine. He was commenting on the post I made. I was only saying that the link to cancer in celiacs may not be a direct link. It could be the processed gluten free foods we eat. The gluten free processed food could be the reason we have a higher risk of cancer. (According to their study) Many other studies say something different. 🙂

    Link to comment
    Share on other sites
    cristiana
    51 minutes ago, LP023 said:

    It’s perfectly fine. He was commenting on the post I made. I was only saying that the link to cancer in celiacs may not be a direct link. It could be the processed gluten free foods we eat. The gluten free processed food could be the reason we have a higher risk of cancer. (According to their study) Many other studies say something different. 🙂

    No problem - I am sure all the processed stuff can't be doing much good on all sorts of levels. My mother in law has always cooked from scratch and enjoys fantastic health in her 80s, I'm sure that's why. 

    Link to comment
    Share on other sites
    Wheatwacked

    I have no doubt it is the low vitamin D and iodine levels we are encouraged to follow.  And deficiency in other vitamins that prevent defective DNA by apoptosis. It's like losing all of your local police due to attrition. US adults are 42% deficient in D, the communication net of the immune system and barely enough iodine for thyroid health. There are others.  That's why it is important to exceed the Recommended Daily Allowances.

         June 1, 2014 Iodine and Cancer     "The first report of geographical regions with high rates of goiter having higher rates of cancer mortality was published in 1924."

    Choline and dna

    Quote

    In the US, dietary intake of choline is marginal. Choline deficiency in people is associated with liver and muscle dysfunction and damage, with apoptosis, and with increased DNA strand breaks...   Choline deficiency alters DNA methylation, which alters gene expression for critical genes involved in DNA mismatch repair, resulting in increased mutation rates. Any dietary deficiency which increases mutation rates should be associated with increased risk of cancers, and this is the case for choline deficiency. In rodent models, diets low in choline and methyl-groups result in spontaneous hepatocarcinomas. In human epidemiological studies, there are interesting data that suggest that this also may be the case for humans, especially those with SNPs that increase the dietary requirement for choline. Dietary Choline Deficiency causes DNA Strand Breaks

     

    Link to comment
    Share on other sites



    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Scott Adams
    PD-L1 in Small Bowel Adenocarcinoma More Common in Celiac Patients
    Celiac.com 04/28/2020 - People who suffer from small bowel adenocarcinomas (SBAs) usually have poor outcomes, and face limited treatment options. Programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway blockade is an effective treatment in many micro-satellite instability-high (MSI-H) solid tumors. 
    A team of researchers recently set out to investigate PD-L1 and PD-1 expression in non-hereditary, non-ampullary SBAs, associated with celiac disease, Crohn’s disease, or sporadic, recruited through the Small Bowel Cancer Italian Consortium. 
    The researchers assessed PD-L1 and PD-1 by immunohistochemistry in a series of 121 surgically resected SBAs, including 34 celiac disease-SBAs, 49 CrD-SBAs, and 38 sporadic SBAs. They found that expression of PD-...


    Scott Adams
    Low Overall Risk of Small Bowel Adenocarcinoma in People with Celiac Disease
    Celiac.com 08/10/2020 - Small bowel cancers are on the rise. Research has shown some possible connections with celiac disease, but there have not been any detailed large group studies. To better understand the connections between celiac disease and small bowel cancers, a team of researchers recently set out to conduct a large group study.
    The UK and Swedish based team turned to the nationwide ESPRESSO cohort study to gather data on everyone diagnosed for celiac disease from 1965 through 2017 at any of the twenty-eight pathology centers in Sweden. 
    They defined celiac disease as duodenal or jejunal villous atrophy, with a stage 3 Marsh score, and matched celiac patients with up five control subjects randomly chosen from the general population. They used stratified Cox regression to...


    Jefferson Adams
    Major Cohort Study Assesses Cancer Risk in Celiac Disease
    Celiac.com 09/20/2021 - People with celiac disease face an increased risk of death, in part due to cancer. Most studies investigating this cancer risk involved patients diagnosed before widespread increases in celiac disease diagnosis rates and access to gluten-free food. A team of researchers recently conducted a population-based study to assess the risk of cancer for people with celiac disease.
    For their study, the team used the Epidemiology Strengthened by histoPathology Reports in a Swedish cohort to gather data from all celiac disease patients in Sweden, with celiac disease defined as duodenal/jejunal villus atrophy. 
    They then matched each patient by age, sex, and county to five or fewer control subjects. Then, following patients from diagnosis until first cancer, o...


    Jefferson Adams
    Celiac Disease Brings a Higher Risk of Colorectal Cancer
    Celiac.com 04/10/2023 - The association between celiac disease and the development of small bowel lymphoproliferative disorders and esophageal adenocarcinoma is well-established, but there is limited evidence of an increased risk of colorectal cancer in these patients. 
    Cross-sectional Population-based Study
    To evaluate the risk of developing colorectal cancer in patients with celiac disease a team of researchers recently conducted a cross-sectional population-based study using a commercial database that contains the electronic health records from 26 major integrated US healthcare systems. 
    The team included patients aged 18-65 years of age, and excluded those with inflammatory bowel disease. They used multivariate analysis to calculate the risk of developing colorectal can...


  • Recent Activity

    1. - Kathleen JJ replied to Kathleen JJ's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Options - 7 year old boy - Helicobacter pylori and serology

    2. - StaciField replied to StaciField's topic in Related Issues & Disorders
      6

      My bone structure is disintegrating and I’m having to have my teeth removed

    3. - Kathleen JJ replied to Kathleen JJ's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Options - 7 year old boy - Helicobacter pylori and serology

    4. - cristiana replied to Kathleen JJ's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Options - 7 year old boy - Helicobacter pylori and serology

    5. - Kathleen JJ posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Options - 7 year old boy - Helicobacter pylori and serology


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      126,055
    • Most Online (within 30 mins)
      7,748

    malcolmg
    Newest Member
    malcolmg
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.1k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Captain173
      10
    • jjiillee
      5
    • Kristina12
      7
    • StaciField
    • ShRa
      9
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...