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  • Scott Adams
    Scott Adams

    More Than Half of Human Gut Bacteria Could Be Harmed by Glyphosate

    Reviewed and edited by a celiac disease expert.

    A new study says that glyphosate may have a negative affect on more than half of human gut microbiota.

    More Than Half of Human Gut Bacteria Could Be Harmed by Glyphosate - Image: CC BY 2.0--JeepersMedia
    Caption: Image: CC BY 2.0--JeepersMedia

    Celiac.com 12/07/2020 - A team of researchers has established the first bioinformatics method to determine and test the potential biological sensitivity of living organisms to glyphosate, the chemical in the herbicide commercially marketed as Roundup. Their research shows that glyphosate may negatively affect more than half of bacteria strains that make up the human gut microbiome. 

    The research team included Lyydia Leinoa,Tuomas Talla, Marjo Helandera, Irma Saloniemia, Kari Saikkonen, Suvi Ruuskanena, and Pere Puigbòacd. They are variously affiliated with the Department of Biology, University of Turku, Turku, Finland, the Biodiversity Unit, University of Turku, Finland, the Nutrition and Health Unit, Eurecat Technology Centre of Catalonia, Reus, Catalonia, Spain, and the Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Catalonia, Spain.

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    The team managed to identify the enzyme targeted by the broad-spectrum herbicide, glyphosate, and offers the first bioinformatics method for determining potential glyphosate sensitivity.

    Glyphosate targets an enzyme called 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in the shikimate pathway, which synthesizes three essential aromatic amino acids (phenylalanine, tyrosine and tryptophan) in plants.

    "Based on the structure of the EPSPS enzyme, we are able to classify 80-90% of microbial species into sensitive or resistant to glyphosate," says Docent Pere Puigbò, developer of the new bioinformatics tool.

    Glyphosate has been regarded as safe to use because shikimate pathway is found only in plants, fungi and bacteria. However, the widespread use of glyphosate may reduce the diversity and composition of microbial communities, including the human gut microbiome. 

    The team's new method has allowed them to create a dataset of EPSPS sequences from thousands of species that will enable major research advances. The method resulted in the classification of sequences from nearly 90% of eukaryotes and more than 80% of prokaryotes. 

    Analysis made with the team's new bioinformatics tool shows that more than half of the human core gut bacterial species are potentially sensitive to glyphosate.

    "This groundbreaking study provides tools for further studies to determine the actual impact of glyphosate on human and animal gut microbiota and thus to their health," explains Docent Marjo Helander.

    Read more at the Journal of Hazardous Materials

    Edited by Scott Adams



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    Posterboy

    Scott,

    That is good research thanks for sharing!

    Here is some other research that explains how a genetic disease could be triggered by our environment and it involves our MicroBiome.

    First one entitled "Virus may lead to celiac disease through disruption of intestinal immune homeostasis"

    https://www.gutmicrobiotaforhealth.com/virus-may-lead-celiac-disease-disruption-intestinal-immune-homeostasis/

    And this one just discovered about how Bacteria/Fungi use Thiamine entitled "Born to be wild: Fungal highways let bacteria travel in exchange for thiamine"

    https://www.sciencedaily.com/releases/2020/09/200924114128.htm

    This would explain how the overuse/competition for Thiamine in biological organisms like humans with Dysbiosis like SIBO or possibly Celiac disease can lead to Thin Villi from low Thiamine levels.

    https://www.celiac.com/celiac-disease/how-low-thiamine-can-thin-villi-old-research-rediscovered-and-its-clinical-significance-in-celiac-disease-r5100/:~:text=Beriberi%20is%20is%20caused%20by%20low%20thiamine%20(B1).,thiamin%20deficiency%20on%20intestinal%20functions%20in%20rats%20.%E2%80%9D

    Animals dependence on Thiamine was famously worked out in Lake Trout explaining generalized fish kills.....in a Region.

    https://www.researchgate.net/figure/Hypothetical-interaction-between-contaminants-and-thiamine-deficiency-a-Toxic_fig6_237150892

    And could explain how Glyphosate IE Roundup could be a trigger for Celiac disease.

    See this research entitled

    "Glyphosate (Roundup), pathways to modern diseases II: Celiac sprue and gluten intolerance"

    quoting from the article....

    "Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease match glyphosate's known depletion of these amino acids"

    This is exactly what the newer research discovered just this year on Tryptophan has found.

    https://www.news-medical.net/news/20201022/Tryptophan-found-in-turkeys-can-accelerate-intestinal-healing-in-people-with-celiac-disease.aspx

    I hope this is helpful but it is not medical advise.

    Posterboy,

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    Guest Wendellyn

    Posted

    I grew up on a farm and have no doubt that I was heavily exposed to Round-up. We sprayed fence rows and the area around our pond that was our source of water for the house. From an early age I had digestive issues and not until my daughter was diagnosed did I actually know what I had. I also have several autoimmune diseases, along with Lupus and I am allergic to a lot of pain relievers, including morphine, codeine, all opioids and latex. I realize at the age of 67 it would be very hard to prove that it was Round-up, but it just makes me wonder?

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    Guest ANTHONY COLATRELLA

    Posted

    Glyphosate has been blamed for a whole host of evils without any substative evidence--its claimed carcinogenic effects, despite judicial verdicts, are highly and hotly debated and remain unsettled. I do not see where this article was intended to demonstrate any specific "bad-ogenic" effects---I read the entire article and NOWHERE did I find the words "harmed" or "negative" effect of glyphosate which were used in your introduction of the article so I must assume these were your choice of words and do not seem to be justified by the conclusions of the article--this was an experimental study which appears to show by these authors methods that some of the microbiome is "sensitive" to glyphosate and some is "resistant" ---the effects or consequences of this are not known----the authors conclude: "to determine the actual impact of glyphosate on human gut microbiota...further empirical studies are needed--to reveal glyphosate residues in food, the effects of pure glyphosate on the microbiome...assess the extent to which our EASS amino acid method predicts bacterial susceptibility in vitro and real world scenarios--it is not entirely surprising at all if it WERE shown that glyphosate did have some specific effect on the microbiome since almost anything we ingest---FOOD, MEDICATION--does, so perhaps we should wait for definitive studies before we label very preliminary and non-specific findings as harmful and negative--perhaps a bit rash and prejudicial

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    Scott Adams

    The study concludes that "Analysis made with the team's new bioinformatics tool shows that more than half of the human core gut bacterial species are potentially sensitive to glyphosate," so clearly the possibility that the effects on our microbiome could be negative, not positive. Further, other studies have linked changes in the microbiome over the years with an increase in the overall rates of celiac disease:

    and chemical exposure has also been linked to higher rates of celiac disease:

     and the rates of celiac disease have shot up 400% since the 1950's:

    Sometimes you have to see the forest by looking at the trees.

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    Wheatwacked

    When I think of the Roundup of today I always remember DDT and the Bald Eagle. This research should be commended.

    Norman E. Borlaug Founder, The World Food Prize
    1970 Nobel Peace Prize Laureate These new wheat varieties and improved crop management practices transformed agricultural production in Mexico during the 1940's and 1950's and later in Asia and Latin America, sparking what today is known as the "Green Revolution." Because of his achievements to prevent hunger, famine and misery around the world, it is said that Dr. Borlaug has "saved more lives than any other person who has ever lived."

    Most of the world's wheat today is descended from this research. 

    On 12/16/2020 at 1:20 PM, Scott Adams said:

     and the rates of celiac disease have shot up 400% since the 1950's:

     Glyphosate was first registered for use in the U.S. in 1974.

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    AnonyousCda

    Berberine supplement 1 pill 500mg 3 a day = 1,500mg. Resets proper good gut flora. There is some burping and farts no puns intended. 

    Iodine intake to keep the thyroid nice and strong. Potassium iodide, sodium iodide, molecular iodide from kelp. (selenium)

    Chaga mushroom protect the DNA of the body. 

    Broccoli spouts: cleaning the body that ails us. 

    honorable mentions: Arabinogalactan, licorice root, marshmallow root, slippery elm, aloe vera. 

    Once a celaic/gluten person has good flora and stop eating gluten. Only then the body can repair itself. This will help to increase absorption of nutrients and vitamins. On repairing the damaged inner lining large intestine??? 

    I know, I know $$$. 

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    Guest ANTHONY COLATRELLA

    Posted

    On 12/19/2020 at 10:22 PM, Wheatwacked said:

    When I think of the Roundup of today I always remember DDT and the Bald Eagle. This research should be commended.

    Norman E. Borlaug Founder, The World Food Prize
    1970 Nobel Peace Prize Laureate These new wheat varieties and improved crop management practices transformed agricultural production in Mexico during the 1940's and 1950's and later in Asia and Latin America, sparking what today is known as the "Green Revolution." Because of his achievements to prevent hunger, famine and misery around the world, it is said that Dr. Borlaug has "saved more lives than any other person who has ever lived."

    Most of the world's wheat today is descended from this research. 

     Glyphosate was first registered for use in the U.S. in 1974.

    Borlaug's research resulted in new wheat varieties that improved crop MANAGEMENT and PRODUCTION---more wheat was able to be grown in lesser space -more people were able to be fed-----a great deal of study has shown that it had no effect on the protein composition and more importantly not on the concentration of any of the immunogenic or toxic peptides responsible for celiac disease---in fact some modern wheat varieties contain less of these   

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    Wheatwacked

    "Looking back over the last five decades, several trends are apparent in wheat consumption: an increase in wheat consumption per capita (Rubio-Tapia et al. 2009) (http://www.ers.usda.gov/AmberWaves/september08/findings/wheatflour.htm), an increase in celiac disease-related T-cell stimulatory epitopes in wheat (as for the major epitope Glia-α9, this paper), an increase in the use of gluten in food processing (Day et al. 2006; Atchison et al. 2010), and an increase in the consumption of processed foods. To some extent this can be attributed to an increase in awareness and improved diagnostic techniques. Given the relation between incidence of celiac disease and exposure to cereals, it cannot be ruled out that an increased content of T-cell stimulatory epitopes has also contributed to this increased prevalence." ... "Considering the epitope impact on celiac disease patients of the major immunodominant Glia-α9 epitope, it is concluded from these data that in general the toxicity of modern wheat varieties has increased."

     

    Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease (nih.gov)           Theor Appl Genet. 2010 Nov; 121(8): 1527–1539.
    Published online 2010 Jul 28. doi: 10.1007/s00122-010-1408-4
    PMCID: PMC2963738
    PMID: 20664999

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    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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