Persistent Chemical Exposure Means Higher Celiac Disease Rates

To All,

I think is essentially the same research but has a more pointed emphasis on common household chemicals like "Non-Stick" Teflon....that could be coating our intestines increasing our risk of Celiac disease...

https://medicalxpress.com/news/2020-05-celiac-disease-linked-common-chemical.html

The link to the Environment effecting genes is not new....it just has taken a little while to acknowledge how things in our environment effect our genes....

It is essentially a "two way" street....and not the "one way" street commonly held belief....Celiac disease is a genetic disease with an environmental trigger....we  just don't know what it (trigger) is often...

https://www.upi.com/Health_News/2017/08/16/Genetic-risk-factors-for-disease-can-be-affected-by-environment/4251502820421/

quoting from the above research

"It's been known for a long time that most diseases have both genetic and environmental risk factors," Dr. Tuuli Lappalainen of the New York Genome Center said in a news release.

"But it's actually more complicated than that because genes and environment interact. As demonstrated in our study, a genetic risk factor may manifest only in certain environments"....

They go on to say...."Some of the variants included four associations to diseases such as cholesterol level and Celiac disease....Researchers also discovered a tendency in genetic risk for autoimmune diseases such as lupus and Celiac disease to be enriched for gene regulatory effects altered by the immune state."

Environmental Toxins possibly triggering our Celiac disease makes perfect sense in this context.

I hope this helpful but it is not  medical advise.

Posterboy,

Careful here...  The research only establishes an "association" between high serum levels of persistent organic pollutants and celiac disease and does not establish that those pollutants are an actual "cause" of celiac disease. 

The high pollutant serum levels can also be explained by the high intestinal permeability of existing celiac disease patients which allows these inhaled or ingested pollutants to readily leak from the gut into the bloodstream along with an abundance of toxins released from gut microflora.  (Inhaled pollutants enter the lungs, become trapped in mucus, expelled, swallowed, enter the gut, and then pass through the highly permeable intestinal lining into the bloodstream.) 

The liver then has the job of filtering out and detoxifying all these bloodborne toxins and pollutants, producing special enzymes to break them down.  The high intestinal permeability from existing celiac disease causes a toxin overload for the liver which cannot produce enough enzymes or keep up with the detoxification process allowing the persistent organic pollutants to continually build up in the bloodstream to the high serum levels observed. 

Rather than the high serum pollutant levels causing celiac disease, it is more likely that existing celiac disease is responsible for the greater incidence of high pollutant serum levels in subjects compared to those without celiac disease.  High pollutant serum levels may thus be an indicator that celiac disease likely already exists as opposed to being a cause of celiac disease.  The 30 celiac disease subjects in the study were diagnosed with celiac disease only AFTER their high pollutant serum levels were identified.

Could the agent orange and other chemicals used in Vietnam war be related to my husband's celiac sprue?

I don't think it can be ruled out. This article reminded me of a high school job I had where I worked at a shop that build sprint car engines and had to wash parts with solvent for 1-2 hours a day...no gloves of course. I also wondered if all those solvents were not a trigger in my case.

I agree with all of the above, but also suspect a cause of celiac disease is pesticides like Roundup, and glyphosate that are sprayed on all our produce.  I believe mothers are affected and the pesticides are passed early (in the womb) to the baby, and on thru generations.

Why do they call these pollutants "organic"? I thought organic meant stuff was free of pesticides? I think this term probably confuses a lot of people. I know I was trying to explain it to a friend the other day. Because these days when you see the word Organic you think of organic food that hopefully is free of pesticides, etc. Because I don't really see anything "organic" about a bunch of mammade chemicals like nonstick surfaces or stuff inside plastic or pesticides, etc.

1 hour ago, TrailWalker said:

Why do they call these pollutants "organic"? I thought organic meant stuff was free of pesticides? I think this term probably confuses a lot of people. I know I was trying to explain it to a friend the other day. Because these days when you see the word Organic you think of organic food that hopefully is free of pesticides, etc. Because I don't really see anything "organic" about a bunch of mammade chemicals like nonstick surfaces or stuff inside plastic or pesticides, etc.

Like most words in the English language, there can be many definitions.  A dictionary or a quick google search can be useful and enlightening.  

Another view of time dependent reaction to irritant exposure is demonstrated when a person quickly rinses a harsh chemical from their skin to completely resolve the concern. If irritants do not stick around the results won't likely be chronic.

I can't find enough exploration into the mundane aspects of prolonged contact of irritants and antigens from the physical aspects of stickiness found in gluten and its combination with environmental irritants. Unwanted substance could amount to everything that 'stings your eye' or creates a blister when applied within the lower lip and held in place for 5 or 10 minutes. 

That's a 'reach', of course, but more reach towards nuances of heightened reactions via extended contact is needed..IMHO. And there is chemistry in that!

There is chemistry for extending contact, perfusion, and grab are more. Observing the chemistry of glues and polymers, you find aspects of emulsifiers, wetting agents, catalysts of polymerization, gelling agents, driers, thickeners, etc ad-nauseum. 

Add a related focus on the absorptive capacity of a glutenous blob with environmental irritants when they meet. Also, the means by which those irritants gain their propensity to mix, adhere, and further their entry under the likeness of a medical patch.

A view towards other sticky food items or inert agents should be included as. 'controls'. However, few are likely to stick around GI conditions to the extent of gliadin.

I could have just said, more 'sticky notes' needed. DOH!!!