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  • Scott Adams
    Scott Adams

    Probiotics May Reduce GI Symptoms in Celiac Disease Patients

    Reviewed and edited by a celiac disease expert.

    A recent systematic review and meta-analysis of randomized controlled trials shows that probiotics may help to reduce gastro-intestinal symptoms in celiac patients.

    Probiotics May Reduce GI Symptoms in Celiac Disease Patients - Probiotics. Image: CC BY 2.0--Ryan Snyder
    Caption: Probiotics. Image: CC BY 2.0--Ryan Snyder

    Celiac.com 11/02/2020 - Many people with celiac disease experience persistent symptoms despite adhering to the gluten-free diet. Different studies have assessed the use of probiotics as an adjuvant treatment for celiac disease. 

    A team of researchers recently set out to to evaluate the efficacy of probiotics in improving gastrointestinal (GI) symptoms and quality of life (QOL) in patients with celiac disease, and used EMBASE, MEDLINE, CINAHL, Web of Science, CENTRAL, and DARE databases to search for randomized controlled trials (RCTs) evaluating probiotics compared with placebo for treating celiac disease, before February 2019. 

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    The researchers collected data on GI symptoms, QOL, adverse events, serum tumor necrosis factor-α, intestinal permeability, and microbiota composition. After examining 2,831 records, they found seven articles describing 6 RCTs, totaling 5,279 participants, that met their eligibility criteria for quantitative analysis. 

    Probiotic use increased Bifidobacteria an average of 0.85 log colony-forming units (CFU) per gram. When measured by the GI Symptoms Rating Scale, which measures average difference symptom reduction, probiotics reduced GI symptoms. However, there was no difference in GI symptoms after probiotics when different questionnaires were pooled. 

    There was just not enough data on tumor necrosis factor-a levels or QOL for probiotics compared with placebo. Meanwhile, the team saw no difference in adverse events between probiotics and placebo. 

    Because the overall certainty of the evidence ranged from very low to low, the best the team can say is that probiotics MAY be helpful to celiac patients. The team is calling for high-quality clinical trials to increase the certainty of the data in this matter.

    Do you have celiac disease, and take probitiotics to help your gut health? Do they help? Share your experience in our comments section.

    Read more in Am J Gastroenterol. 2020 Oct;115(10):1584-1595.

     

    The research team included Caroline L Seiler, Michel Kiflen, Juan Pablo Stefanolo, Julio César Bai, Premysl Bercik, Ciaran P Kelly, Elena F Verdu, Paul Moayyedi, Maria Ines Pinto-Sanchez. They are variously affiliated with the Department of Medicine, Farncombe Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada; the Population Health Research Institute, Genetic and Molecular Epidemiology Laboratory, Hamilton, Ontario, Canada; the Hospital de Gastroenterologia Dr C B Udaondo, Buenos Aires, Argentina; and the Celiac Center Beth Israel Deaconess Medical Center and Celiac Research Program, Harvard Medical School, Boston, Massachusetts, USA.



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    Posterboy

    To All,

    While it is nice to know.....some Probiotics might help Celiac's....it is much more relevant to know which Probiotics have been studied that one could take specifically take that could help you.

    Since I do a lot of research I came across this research that might help others...

    Entitled "Lactobacillus rhamnosus GG Protects the Epithelial Barrier of Wistar Rats from the Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy"

    Open Original Shared Link

    It specifically has already been studied and follow up studies could be conducted that can confirm this same affect in humans for the Probiotic strain Lactobacillus rhamnosus GG....

    I hope this is helpful but it is not medical advise.

    Posterboy,

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    Guest Scott

    Thanks Poster boy-  do you know of a specific probiotic that you use that has "Lactobacillus rhamnosus GG that is gluten free and you have done well with?  I know some probiotics have been found to contain gluten.  Thanks, Scott

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    Guest Geliza

    I find high strength Saccharomyces boulardi very helpful on occasions, the one I take is a gluten-free, vegan and soy free live culture.

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    Posterboy

    Guest Scott,

    Here are some articles that might help you.

    Open Original Shared Link

    Culturelle is L. GG

    Here is an article about it....

    Open Original Shared Link

    I have taken some on and off....I might try Culturelle again.....I probably didn't take it long enough the first time....I usually have to take something more than once to get it right...

    I do like Kefir and usually us it.....a 99% Lactose Fermented Milk product usually...

    I hope this is helpful but it is not medical advise.

    Posterboy,

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    Posterboy

    Guest Scott,

    This is not a Probiotic but I did find a supplement recently that might also help.

    I started a new thread about it....

    I have bought some....but have had a chance to take it yet....

    Let us know if you find it helps you so it can benefit others too!

    Again I hope this is helpful but it is not medical advise.

    Posterboy,

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    Guest Jean

    I was diagnosed over 20 yrs ago and have struggled every day, even though I follow a strict gluten-free diet.  I started prebiotic about 2 months ago, and I think they have really improved my bloating, I also take a digestive enzyme once a day before my main evening meal, not really sure if this helps, but overall I've been feeling better.  I have had a polyp removed and have recently been diagnosed with diverticular disease.

    I have also purchased Gliding, that break down gluten if ingested by accident, they are great, only a preventative, not to be used as a way of eating gluten, only if feeling unwell due to contamination.

    I look forward to more studies on the subject as we really need help to deal with this bloating and prevent damage to our bowled x

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    Guest DebT

    I am still fairly new to this but have been taking probiotics with psyllium husk and it has helped. I am taking Klaire Labs THER-BIOTIC COMPLETE.

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    Guest Karen

    Hi Scott,

    I was diagnosed with Dermatitus Herpetiformus by a dermatologist two years ago and have been on the gluten-free diet since. I have not been intestinal biopsied, but do experience sudden GI symptoms when accidentally exposed to gluten, usually as a consequence of eating out. I have not had a breakout of the rash (and my liver enzymes have returned to normal) since being on the gluten-free diet. I began taking Lean and Pure Prebiotic & Probiotic Extra Strength brand supplement 3 months ago. It has significantly helped regulate my GI system, so much so that I intend to keep taking it to both support my immune system and manage my GI symptoms. I have recently learned that it is important to purchase probiotic supplements packaged in blister packs instead of bottles so that the quality of the supplement is not compromised by exposure to air--an important factor to consider with your research. This brand is blister packed.  It is also important that the supplement is produced under carefully controlled temperatures. I have tried other probiotic supplements (before being diagnosed with celiac disease-DH) with unremarkable results, and therefore, did not continue purchasing them. I realize now I should have done my homework on how to choose a good probiotic before buying the cheapest one on the shelf. May God bless your research, Scott, and your health. I look forward to reading your book.

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    Guest ANTHONY COLATRELLA

    Posted

    The headline here sounds more optimistic than the actual content of the article----the "MAY" here is a rather weak MAY:  the improvement in symptoms was found only when the GI Symptoms Rating Scale was used, but NO Difference when different rating scales were pooled and over-all---"the certainty of the evidence ranged from very low to low"-----and as Posterboy has pointed out the most relevant issue about the probiotics is which specific probiotics were used in these 6 RCT's and when you read this review and the actual individual studies that comprise it, you find that 5 of the studies used MIXTURES of 2 to several probiotics, the others used one probiotic; all the studies used DIFFERENT probiotics and these are probiotics not necessarily found in OTC products; none of the studies used Lactobacillus rhamnosus GG---so "high quality clinical trials are needed" and in the meanwhile I suspect Celiac patients will search for remedies that MAY work for them

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    Scott Adams

    Yes, our summary does include much of what your summary says... 😄

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    Wheatwacked
    On 11/10/2020 at 12:13 PM, Guest Scott said:

    Thanks Poster boy-  do you know of a specific probiotic that you use that has "Lactobacillus rhamnosus GG that is gluten free and you have done well with?  I know some probiotics have been found to contain gluten.  Thanks, Scott

    Home made kosher dill pickles. Fermented, not quick pickles made with vinegar. It only takes a few days.

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    AnonyousCda

    Research and try out Berberine supplement... then introduce probiotics. 

    For a few days prepare for gassy moments and burps, especially when drinking probiotic kefir/kombucha drinks. Maybe hold back alcohol. 

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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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