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    Rates of Anxiety and Depressive Symptoms Among Patients with Celiac Disease

    Reviewed and edited by a celiac disease expert.

    A new study looks at rates of anxiety and depressive symptoms in celiac patients in Jordan.

    Rates of Anxiety and Depressive Symptoms Among Patients with Celiac Disease - Depressed. Image: CC BY-SA 2.0--Sander van der Wel
    Caption: Depressed. Image: CC BY-SA 2.0--Sander van der Wel

    Celiac.com 07/17/2023 - Celiac disease has been associated with higher levels of anxiety, but study evidence is scant. A team of researchers recently set out to measure the frequency of anxiety and depressive symptoms in Jordanian patients with celiac disease.

    The Research Team

    The research team included Sara Haj Ali, Rahaf Alqurneh, Awni Abu Sneineh, Bandar Ghazal, Lana Agraib, Layali Abbasi, Sufian Rifaei, and Tarek Mazzawi. They are variously affiliated with the department of Medicine, Al-Balqa Applied University, Al-Salt, JOR; the department Gastroenterology and Hepatology, University of Jordan, Amman, JOR; and the department of Food Science and Nutrition, Jerash University, Jerash, JOR. 

    Celiac.com Sponsor (A12):
    Celiac disease is a condition where the immune system reacts to gluten, causing intestinal problems and other symptoms. Researchers conducted a study to understand the frequency of anxiety and depressive symptoms in Jordanian patients with celiac disease.

    Anxiety and Depressive Symptom Questionnaire

    The study involved sending a questionnaire electronically to celiac disease patients through WhatsApp. The questionnaire asked about demographics, disease-related information, and assessed anxiety and depressive symptoms using validated scales.

    A total of 133 patients participated in the study, mostly females with an average age of 33.9 years. About one-third of the patients were not following a gluten-free diet, and more than half were experiencing symptoms at the time of the study. 

    83% Report Depressive Symptoms

    The prevalence of anxiety and depressive symptoms among the participants was found to be high, with 85% reporting anxiety symptoms and nearly 83% reporting depressive symptoms. There were no significant correlations found between the variables and the presence of anxiety or depressive symptoms.

    These findings highlight the significant proportion of Jordanian celiac disease patients who experience anxiety and depressive symptoms. Considering the potential impact on their quality of life, it is important for healthcare providers to screen celiac disease patients for psychiatric comorbidities and refer them for further evaluation if needed. This can help improve their overall well-being and provide appropriate support.

    Read more at Cureus. 2023 Jun; 15(6): e39842


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    Guest mary14889

    Posted

    Was there a control group without celiac disease or gluten intolerance?  It could be that everyday life is very stressful in Jordan in general.  For myself, I was depressed much of my life, until I went gluten free and then it was like the sun came out.  

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    Wheatwacked

    No control group, except as compared to general public. "85% and 82.7%, respectively, which is higher than what was reported in the general Jordanian population"

    It was more of an effort to point out that depression and Celiac go hand in hand.

    Sometimes 1+1 = 2.

         Vitamin D deficiency and associated factors in Jordan "The prevalence of low vitamin D level is extremely high in Jordan. Age, gender, obesity, and unemployment were associated with low levels of vitamin D. Health authorities in Jordan need to increase the level of awareness about vitamin D deficiency and its prevention, particularly among women."

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    sc'Que?
    4 hours ago, Guest mary14889 said:

    Was there a control group without celiac disease or gluten intolerance?  It could be that everyday life is very stressful in Jordan in general.  For myself, I was depressed much of my life, until I went gluten free and then it was like the sun came out.  

    Great question.  I came here to ask basically the same question--though, your verbiage is far better than I might've been able to muster!

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    Guest Socalartgal

    Posted

    On 7/24/2023 at 8:58 PM, Guest mary14889 said:

    Was there a control group without celiac disease or gluten intolerance?  It could be that everyday life is very stressful in Jordan in general.  For myself, I was depressed much of my life, until I went gluten free and then it was like the sun came out.  

    I’m not sure how much of their depression is really tied to being celiac. Lack of vitamin D is a known component of depression. And it is also a fact that darker skin people are more apt to be deficient.  Avoiding all things gluten and taking vitamin D supplements has made a big difference in my gut, my health and my overall well being and yes, less depression and anxiety. 

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    Elizabeth M Blair

    This article actually made me feel less depressed. I am new to this forum and just had the celiac endoscopy and biopsies done last week and learned that I have it. Knowing that depression could be high in some groups of people with Celiac actually made me feel better immediately.  I thought, at least in this survey, it's the norm and then some to feel anxious and depressed about having celiac, both of which I had been feeling. 

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    trents
    19 minutes ago, Elizabeth M Blair said:

    This article actually made me feel less depressed. I am new to this forum and just had the celiac endoscopy and biopsies done last week and learned that I have it. Knowing that depression could be high in some groups of people with Celiac actually made me feel better immediately.  I thought, at least in this survey, it's the norm and then some to feel anxious and depressed about having celiac, both of which I had been feeling. 

    Eizabeth, the depression associated with celiac disease may also have a nutritional deficiency base. The damage done to the small bowel villous lining by celiac disease reduces the efficiency of vitamin and mineral absorption for those having lived with celiac disease for years without knowing it. We typically recommend some heavy duty vitamin and mineral supplementation to those who have been newly diagnosed.

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    Elizabeth M Blair

    Thank you so much, Trents.  I do think I have had it for a long time. What vitamin and mineral supplements would you suggest. CA I imagine and Vit C.  Anything else?

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    trents
    16 minutes ago, Elizabeth M Blair said:

    Thank you so much, Trents.  I do think I have had it for a long time. What vitamin and mineral supplements would you suggest. CA I imagine and Vit C.  Anything else?

    • Adult multivitamin
    • B-complex. It usually comes combined with vitamin C.
    • D3- 5000 to 10,000 IU daily
    • Magnesium glycinate or magnesium citrate (not magnesium oxide. It is not very bioavailable) - follow directions on bottle for dosage but be aware magnesium may cause loose stools so cut back some if necessary. I have settled on 200 mg daily of magnesium glycinate. You won't find this form in chain stores so you may need to order it from Amazon or you may find it in a vitamin store.
    • sublinqual B12 - 2500 mg daily
    • zinc - check daily dosage recommendations on the bottle. Zinc oxide is okay. zinc picolinate is better

    The above are all safe dosages. B vitamins are all water soluable so you just pee out the excess and it will make your pee bright yellow. This is a good sign. The D3 and B-complex are most likely to be critical in your case of all those I've listed. Costco Kirkland signature and Nature Made brands are good choices. Most of their products are gluten free and will say so on the package/bottle.

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    Elizabeth M Blair

    Trents, Thank you so much for the valuable information that I'm sure others newly aware of having celiac will also appreciate.  I will track down these vitamins. I appreciate you!

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    trents
    5 minutes ago, Elizabeth M Blair said:

    Trents, Thank you so much for the valuable information that I'm sure others newly aware of having celiac will also appreciate.  I will track down these vitamins. I appreciate you!

    These vitamin and mineral supplements are not going to be a quick fix. Give it about 3-4 months to see if there is a difference. D3 is turning out to be a master vitamin for the body and most who live in the civilized world are chronically low in D3 levels because we spend so much time indoors and out of the sun. Life guards in tropical locations would be an exception, hee, hee! RMDA levels are not the same as optimum levels of vitamins and minerals. RMDA is only good enough to ensure you don't get beriberi, scurvy and such obvious things like that.

    Edited by trents
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    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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