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  • Jefferson Adams
    Jefferson Adams

    Study Shows GI Symptoms in Behçet's Disease, But No Clear Celiac Connection

    Reviewed and edited by a celiac disease expert.

    Behçet's disease shares some similarities with celiac disease, but there is very little data about a possible link between the two diseases.

    Study Shows GI Symptoms in Behçet's Disease, But No Clear Celiac Connection - Image: CC--Ajay Goel
    Caption: Image: CC--Ajay Goel

    Celiac.com 02/14/2019 - Behçet's disease is a rare disorder that causes blood vessel inflammation throughout the body. Symptoms and effects of the disease can seem unrelated, and can include mouth sores, eye inflammation, skin rashes and lesions, and genital sores. Other symptoms can include joint swelling and pain, and, more rarely, inflammation in the brain and nervous system that leads to headache, fever, disorientation, poor balance or stroke.

    Behçet's disease shares some similarities with celiac disease, but there is very little data about a possible link between the two diseases. Moreover, reports of gastrointestinal (GI) symptoms with marked upper GI symptoms in Behçet's disease are rare. A new study looks at celiac disease prevalence in a large series of patients with Behçet's disease

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    A team of researchers recently set out to determine rates of celiac disease and to assess endoscopic findings in Turkish Behçet's disease patients. The research team included Erdem Koçak  Erdem Akbal  Yavuz Beyazit  Bilal Ergül  Arzu Karataş  Seyfettin Köklü, and H. Meral Ekşioğlu. They are variously affiliated with the Department of Gastroenterology, Faculty of Medicine, Istanbul Bilim University in Istanbul; the Department of Gastroenterology at ßanakkale State Hospital in ßanakkale; the Department of Gastroenterology at Kırsßehir State Hospital in Kırsßehir; the Department of Dermatology at the Ankara Education and Research Hospital; and the Department of Gastroenterology at Hacettepe University Hospital in Ankara, Turkey.

    For the study, a total of 210 patients with Behçet's disease received anti‐gliadin and tissue transglutaminase antibody blood tests. The research team performed endoscopy in 190 patients, and performed duodenal biopsies on patients with positive serological assessment for celiac disease. Just over 4% of Behçet's disease patients tested positive for anti‐gliadin and tissue transglutaminase antibody immunoglobulin A (IgA) and IgG antibodies. Just over 1% of Turkish Behçet's disease patients had biopsy‐confirmed celiac disease. Antral gastritis, duodenitis and esophagitis were the most common GI findings in patients with Behçet's disease.

    Clinically, Behçet's disease and celiac disease seem to have some things in common, but this study showed no clear connection between the two. Stay tuned for more on the latest research on possible connections between Behçet's disease and celiac disease. 

    Source: International Journal of Rheumatic Diseases


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    Guest Anne

    I wonder how many would have improved symptoms if they had tried a gluten-free diet for at least a month. Gluten is so much more than celiac disease. 

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    Guest Behcets

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    Our 17 yo granddaughter shows nearly every sign of Behcet's. We all have celiac. My husband and her have the HLA-DRB1 and HLA-B genes that one study showed may be associated with Behcets. We now think some of his skin ailments have been related to Behcets, too. He, our daughter and granddaughter all have the HLA- DQA1, HLA-DQ2.5 which is associated with the dermatitis herpetiformis which generally has skin lesions and rashes. I carry the HLA-DQB1, HLA-DQ8 sequences as do the girls, also. My husband was not diagnosed with celiac until he was in his 60's and his kidneys were failing. We are now gluten-free and that has helped us greatly, but within the last year these other symptoms started occurring more regularly in our granddaughter. Ahe is a medical student and started researching her symptoms and came across a group of people that have been determined to have Behcet's, she's been corresponding with them and their stories are very much the same as hers. Some say their symptoms started or got worse in the later teens. One 40 year old woman said she only recently was diagnosed after years of pain, going from doctors to specialists and not getting any answers. Our granddaughter is extremely depressed, due to pain, lesions that won't heal after the use of many prescribed ointment's and medicines, headaches, eyesight problems and such. We will be curious to hear if your research does find a link between Celiac and Behcets.

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    trents

    Most consider Behcets to be an autoimmune disorder, as is celiac disease. We also know that a number of other autoimmune diseases that commonly are seen in the celiac population (Hashimoto, type 2 diabetes, lupus, etc.)  are located in the same genome region as is celiac disease. Perhaps that is a connection, though I realize my answer is kind of general.

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    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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