Study to Examine Different Celiac Disease Phenotypes in Adults

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By Jefferson Adams

August 31, 2024
By Jefferson Adams • August 31, 2024

Study to Examine Different Celiac Disease Phenotypes in Adults

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Reviewed and edited by a celiac disease expert.

A new study will allow researchers to compare genetic, clinical, immunological, micobiota and novel biomedical markers between celiac disease phenotypes and control subjects, along with assessing their prognostic value.
Caption:
Comfortable Research by Joel Bedford is licensed under CC BY-ND 2.0.

Celiac.com 8/31/2024 - Understanding that celiac disease can look different in different people has helped doctors learn more about it. However, we still don't know what causes these differences, and exactly what they might mean for each individual. Because celiac disease varies so much from person to person, we need more personalized care and follow-up guidelines to better support each case.

A new study will recruit celiac disease and dermatitis herpetiformis patients, along with healthy control volunteers.

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The study will allow researchers to compare genetic, clinical, immunological, micobiota and novel biomedical markers between celiac disease phenotypes and control subjects, along with assessing their prognostic value.

Study Purpose

The main goal of the study is to examine genetic, blood, immune system, and gut bacteria differences between various types of celiac disease. The researchers also want to find markers that can help predict how each type of celiac disease will develop.

Inclusion Criteria

Cohorts 1 and 2: Celiac disease or dermatitis herpetiformis diagnosis.

Cohort 3: friend or non-related family member of celiac disease or dermatitis herpetiformis patient.

Exclusion Criteria

Cohorts 1-3 will exclude anyone under 18 years of age.

Cohorts 1 and 2 will exclude anyone with unconfirmed celiac disease or dermatitis herpetiformis diagnosis.

Cohort 3 will exclude anyone with a diagnosis of celiac disease or dermatitis herpetiformis.

Arms

Celiac disease patients

Adult (18 years or over) patients with previous celiac disease or dermatitis herpetiformis diagnosis

Healthy controls
The study will include 500 adults, aged 18 years or over, friends or non-related family members of celiac disease or dermatitis herpetiformis patients, all with no previous celiac disease or dermatitis herpetiformis diagnosis. An additional 1000 control subjects will be included from Biobank

Interventions

Genetic

Genetic predisposition

Assessment of genetic predisposition to various celiac disease phenotypes. No intervention.

Contact a Trial Team
Those interested in learning more about this trial should find the trial site nearest to your location and contact the site coordinator via email or phone. The sponsors also "strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service..."

Read more at trials.celiac.org
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About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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