Study to Examine Different Celiac Disease Phenotypes in Adults

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
By Jefferson Adams

August 31
By Jefferson Adams • August 31

Study to Examine Different Celiac Disease Phenotypes in Adults

Followers 1
Reviewed and edited by a celiac disease expert.

A new study will allow researchers to compare genetic, clinical, immunological, micobiota and novel biomedical markers between celiac disease phenotypes and control subjects, along with assessing their prognostic value.
Caption:
Comfortable Research by Joel Bedford is licensed under CC BY-ND 2.0.

Celiac.com 8/31/2024 - Understanding that celiac disease can look different in different people has helped doctors learn more about it. However, we still don't know what causes these differences, and exactly what they might mean for each individual. Because celiac disease varies so much from person to person, we need more personalized care and follow-up guidelines to better support each case.

A new study will recruit celiac disease and dermatitis herpetiformis patients, along with healthy control volunteers.

Celiac.com Sponsor (A12):
The study will allow researchers to compare genetic, clinical, immunological, micobiota and novel biomedical markers between celiac disease phenotypes and control subjects, along with assessing their prognostic value.

Study Purpose

The main goal of the study is to examine genetic, blood, immune system, and gut bacteria differences between various types of celiac disease. The researchers also want to find markers that can help predict how each type of celiac disease will develop.

Inclusion Criteria

Cohorts 1 and 2: Celiac disease or dermatitis herpetiformis diagnosis.

Cohort 3: friend or non-related family member of celiac disease or dermatitis herpetiformis patient.

Exclusion Criteria

Cohorts 1-3 will exclude anyone under 18 years of age.

Cohorts 1 and 2 will exclude anyone with unconfirmed celiac disease or dermatitis herpetiformis diagnosis.

Cohort 3 will exclude anyone with a diagnosis of celiac disease or dermatitis herpetiformis.

Arms

Celiac disease patients

Adult (18 years or over) patients with previous celiac disease or dermatitis herpetiformis diagnosis

Healthy controls
The study will include 500 adults, aged 18 years or over, friends or non-related family members of celiac disease or dermatitis herpetiformis patients, all with no previous celiac disease or dermatitis herpetiformis diagnosis. An additional 1000 control subjects will be included from Biobank

Interventions

Genetic

Genetic predisposition

Assessment of genetic predisposition to various celiac disease phenotypes. No intervention.

Contact a Trial Team
Those interested in learning more about this trial should find the trial site nearest to your location and contact the site coordinator via email or phone. The sponsors also "strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service..."

Read more at trials.celiac.org
adults

celiac disease

phenotypes

study
Share
Followers 1
Go to articles
User Feedback
- 0 Comments
Recommended Comments

There are no comments to display.

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!
Register a new account

Sign in

Already have an account? Sign in here.
Sign In Now
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

>VIEW ALL ARTICLES BY JEFFERSON ADAMS
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Study Shows Grain-Fed Beef is Naturally Gluten-Free
Celiac.com 12/23/2019 - Over the years, there's been some debate among celiac sufferers about meat. Specifically, is beef from conventionally-raised, grain-finished cattle gluten-free and safe to eat? It seems intuitive that cattle fed with grain might somehow contain gluten in their meat.
Many celiac sufferers claim to be sensitive to such beef, while others, either unsure, or worried about the possibility of contamination avoid eating conventional beef. These concerns lead many celiac sufferers to specifically seek out grass-fed beef, which is naturally gluten-free, but also typically more expensive than grain-fed beef.
Since people with celiac disease and non-celiac gluten sensitivity need to avoid gluten, it's crucial for them to know whether their food might contain gluten...

Read Full Article...

1 comment

13,159 views
Study Explores the Link Between Covid-19 and Celiac Disease
Celiac.com 06/12/2023 - Celiac disease is an autoimmune disorder characterized by gastrointestinal symptoms and nutrient deficiencies. While genetic factors, particularly HLA association, play a significant role in its development, the exact environmental triggers remain unclear.
Recent studies have proposed infections as potential contributing factors. With the Covid-19 pandemic causing a systemic inflammatory response and affecting the gastrointestinal tract, researchers in southern Sweden set out to investigate whether Covid-19 infection could increase the risk of developing celiac disease.
The research team included Jesper Lexner, Ylva Lindroth and Klas Sjöberg. They are variously affiliated with the Department of Gastroenterology and Nutrition, Department of Clinical Sc...

Read Full Article...

1 comment

2,738 views
Study Looks at Health Disparities and Autism
Celiac.com 11/08/2023 - Autistic adults often face more significant health challenges than their non-autistic counterparts, as revealed by numerous epidemiological studies. Although this issue has been explored, research has mainly been confined to specific geographical areas and has centered on young autistic individuals aged 35 and under.
Recent research points to a higher mortality rate in autistic people and less satisfactory self-reported healthcare experiences. A team of researchers recently set out to examine increased rates of chronic physical health conditions in autistic adolescents and adults.
The research team included John H. Ward, Elizabeth Weir, Carrie Allison & Simon Baron-Cohen. They are variously affiliated with the Royal Devon University NHS Foundation T...

Read Full Article...

0 comments

1,975 views
Study Looks at Iron Levels and Celiac Disease Development
Celiac.com 02/14/2024 - Rising celiac disease rates pose a significant health challenge, yet the environmental triggers behind the rise remain elusive. Among the various potential factors, iron deficiency has emerged as a potential contributor to the development of celiac disease. A recent study, employing Mendelian randomization (MR), sought to investigate the intricate relationship between iron status and the prevalence of celiac disease.
Understanding Mendelian Randomization
Mendelian randomization (MR) is a powerful method that explores potential causal relationships between an exposure and an outcome. In this case, the researchers delved into the connection between genetic variants associated with iron status and the presence of celiac disease.
Research Design ...

Read Full Article...

13 comments

5,003 views
Recent Activity
1. 1 hour ago - Wheatwacked replied to kate g's topic in Coping with Celiac Disease
  12
  
  So worried about 11 year old daughter
  
  Why the iron? Have the doctors tested for vitamin D. Is she eating enough eggs, milk, meat? Start her on the Thiamine today. The minimum for a child of four years is 0.6 milligrams. That's 600 mcg. That is 3X the minimum folate (200 mcg). fThere is no established upper limit for thiamin intake in humans because there is no evidence of adverse...
2. 4 hours ago - trents replied to Deborah123's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  4 year old with a negative Celiac test
  
  Looks like what was not done that should have been done was Total IGA. If total IGA is low, it can drive other IGA scores down toward the negative range. Was he avoiding wheat-based foods by any chance when the blood draw was taken?
3. 5 hours ago - Deborah123 replied to Deborah123's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  4 year old with a negative Celiac test
  
  We did these: Antigliadin Abs, IgA Antigliadin Abs, IgG tTg IgA Endomysial Antibody IgA
4. 5 hours ago - trents replied to Deborah123's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  4 year old with a negative Celiac test
  
  Welcome to the forum, @Deborah123! Can you be more specific about which blood test for celiac disease was done? Do you have a record of the testing that you can access? There are several that should be ordered by many physicians will only order the tTG-IGA which may not be a good choice for a child so young because their immune systems are immature. ...
5. 5 hours ago - Deborah123 posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  4 year old with a negative Celiac test
  
  My 4 year old was tested for celiac last summer (blood test) & it came back normal / negative. Can the blood test be wrong? I was surprised that he was negative - there are many things going on which would indicate celiac. - He is very tired & irritable - He is quite small for his age - He has enamel hypoplasia He had amino...