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  • Scott Adams
    Scott Adams

    By Scott Adams •

    The Appeal of Vaccine Treatments for Celiac Disease

    Reviewed and edited by a celiac disease expert.

    Recent preliminary data suggest that the main involvement of innate immune pathways, versus adaptive immune pathways, might help explain clinical and serological differences among celiac disease patients.

    The Appeal of Vaccine Treatments for Celiac Disease - Image: CC BY 2.0--Daniel Paquet
    Caption: Image: CC BY 2.0--Daniel Paquet

    Celiac.com 12/21/2020 - Recent leaps in understanding the development of celiac disease have led efforts toward a new, non-dietary, vaccine therapy. 

    A lifelong gluten-free diet remains the only treatment for celiac disease, but research shows that even the most diligent gluten-free dieters are likely to be exposed to gluten on a regular basis. This is part of the appeal of safe, effective non-dietary treatments for celiac disease. And adjunctive and/or vaccine therapy is one of those approaches.

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     New therapies might focus on immune regulation by IL-10, as in vitro models of treated celiac patients show that external IL-10 can overwhelm the gliadin driven IFN-γ response in intestinal biopsies. But, even though people with active celiac disease show high levels of anti-inflammatory IL-10 it's not enough to suppress the overwhelming Th1-mediated response.

    However, vaccination with gluten might trigger the extension of regulatory T cells, which could restore oral tolerance to gluten. It remains to be seen whether these approaches can strongly decrease the inflammatory intestinal response in celiac disease. 

    A few experimental clinical trial studies have been run, though only one trial has used concurrent gliadin-based immunotherapy; that study is numbered NCT00879749 using the ClinicalTrials.gov Identifier. 

    One recent study indicated a safety evaluation and estimates an inducible immune response by intradermal injections of Nexvax2 in treated celiac patients, which is specific to HLA-DQ2 patients. That vaccine contains three gluten peptides established by ImmunsanT for the treatment of celiac disease. These epitopes are responsible for the various immune responses by isolated T cells. A phase I in 40 HLA-DQ2+ celiac disease patients, using subcutaneous doses, showed no clinically applicable harmful effects.

    So far, however, few experimental therapies have been emerged as new targets for celiac disease in phase I–II trials and larger randomized controlled trials. Any suitable unique therapy needs to be harmless, operative and inexpensive. This invites further examination into the development of a new non-dietary treatment for celiac disease patients.

    Read the full paper by Mohammad Rostami Nejad of the Celiac Disease Department, Gastroenterology and Liver Diseases Research Center at Shahid Beheshti University of Medical Sciences in Tehran, Iran in the International Journal of Celiac Disease, 2015, Vol. 3, No. 4, 115-117.


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    Posterboy

    Scott,

    I tried clicking on your link to read it in more detail....but It didn't work for me....

    I have been busy with life issues.....so I am just now getting around to comment....

    Could you verify the Link is good and let me know If it works for you or others.

    Thanks,

    Posterboy,

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    RMJ
    3 hours ago, Posterboy said:

    Scott,

    I tried clicking on your link to read it in more detail....but It didn't work for me....

    I have been busy with life issues.....so I am just now getting around to comment....

    Could you verify the Link is good and let me know If it works for you or others.

    Thanks,

    Posterboy,

    Posterboy,

    Here is a better link.  It is a short article.  I tried downloading the pdf but it wasn’t any longer.

    Open Original Shared Link

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    Rhyo9

    Thanks for this story; I needed some good news today.

    Is there any work being done on other ways to increase IL-10 or Treg function in Celiac?

    There has been research showing that mannose (the sugar that is popularly used for urinary tract infections) increases Treg function:

    Open Original Shared Link

    Stem cell-based therapy benefits are in part due to increasing IL-10, and cell free exosome based therapies (exosomes derived from stem cells) show promise in terms of efficacy, safety and cost.

    ~

    The paper by Nejad is not indexed by PubMed; indexing in PubMed is not an indication of quality. Lately I have noticed a number of scholarly papers not showing up in PubMed and this is unfortunate. For people that like reading up on biomedical topics, be aware that searching PubMed alone is no longer sufficient for a thorough search.

     

     

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    Posterboy
    21 hours ago, RMJ said:

    Posterboy,

    Here is a better link.  It is a short article.  I tried downloading the pdf but it wasn’t any longer.

    Open Original Shared Link

     

    8 hours ago, Rhyo9 said:

    Thanks for this story; I needed some good news today.

    Is there any work being done on other ways to increase IL-10 or Treg function in Celiac?

    There has been research showing that mannose (the sugar that is popularly used for urinary tract infections) increases Treg function:

    Open Original Shared Link

    Stem cell-based therapy benefits are in part due to increasing IL-10, and cell free exosome based therapies (exosomes derived from stem cells) show promise in terms of efficacy, safety and cost.

    ~

    The paper by Nejad is not indexed by PubMed; indexing in PubMed is not an indication of quality. Lately I have noticed a number of scholarly papers not showing up in PubMed and this is unfortunate. For people that like reading up on biomedical topics, be aware that searching PubMed alone is no longer sufficient for a thorough search.

     

     

    RMJ et Al,

    Thanks for the Link!

    Here is a couple research articles you might enjoy reading.

    I have been trying to make sense of them.  Maybe you can offer some insight....

    I have planned on writing a blog post about them especially the new research on Tryptophan but I haven' had time to complete it  yet.  Maybe I will finish it soon!

    Open Original Shared Link

    Open Original Shared Link

    I hope this is helpful but it is not medical advice.

    Posterboy,

    ETA: Here is longer and probably better description of Virus's ((Environment) could/can trigger an Genetic disease like Celiac disease...

    Open Original Shared Link

    The research is a couple years old.....also the Epstein Barr Virus has also been associated with Celiac disease.

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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.

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