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  • Scott Adams
    Scott Adams

    Uncovering the Genetic Connection Between Heart Disease, Celiac Disease and Psoriasis

    Reviewed and edited by a celiac disease expert.

    For those with celiac disease, the results are reassuring as they show no genetic link between cardiovascular risks and the condition.

    Celiac.com 10/23/2024 - Cardiovascular diseases, such as coronary artery disease and stroke, have long been connected with various immune-mediated disorders due to the role inflammation plays in both conditions. This study explores whether there is a genetic connection between cardiovascular diseases and specific immune-mediated diseases, with a particular focus on psoriasis. Psoriasis is a chronic inflammatory condition that has previously been associated with an increased risk of cardiovascular disease. However, it is unclear whether the genetic risk factors for cardiovascular disease are also linked to an increased risk of psoriasis and other immune-related conditions.

    Study Objectives

    The main goal of the study was to investigate whether genetic predispositions to coronary artery disease and stroke also increase the risk of developing psoriasis or other immune-mediated diseases. The researchers utilized a method called Mendelian randomization, which uses genetic data to determine whether there is a causal relationship between two traits, as opposed to just an observed association. By using large datasets from genome-wide association studies, the study aimed to uncover whether genetic predictors of cardiovascular disease are directly linked to immune-mediated diseases, such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease.

    Methods and Data

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    To conduct the analysis, the study used Mendelian randomization to evaluate the genetic links between cardiovascular disease and immune-mediated diseases. This approach is particularly effective in differentiating causality from correlation because it uses genetic markers as proxies for risk factors. The researchers analyzed summary data from genome-wide association studies for coronary artery disease, stroke, psoriasis, and nine other immune-mediated diseases. The data included a large sample of participants, with over 1.1 million individuals for cardiovascular disease traits and nearly 500,000 for psoriasis.

    The study specifically examined whether genetic markers associated with coronary artery disease and stroke were linked to an increased risk of developing psoriasis or any of the other immune-mediated diseases.

    Key Findings

    The results of the study revealed that genetic predictors for both coronary artery disease and stroke were significantly associated with an increased risk of psoriasis. In particular, genetic risk factors for coronary artery disease were found to increase the risk of developing psoriasis by about 7%, while genetic risk factors for stroke increased the risk by 22%. Interestingly, when adjustments were made for stroke risk, the association between coronary artery disease and psoriasis became statistically insignificant. This suggests that there may be a shared genetic component that links both cardiovascular diseases and psoriasis, rather than two separate pathways.

    On the other hand, the study found no significant genetic link between cardiovascular disease risk factors and other immune-mediated diseases, such as rheumatoid arthritis and inflammatory bowel disease. This finding was somewhat unexpected, as these diseases also involve inflammation, which is thought to be a common factor in both cardiovascular disease and immune-mediated disorders.

    Genetic Risk and Celiac Disease

    The study also explored the relationship between genetic predictors of cardiovascular disease and various immune-mediated diseases, including celiac disease. Data from 4,533 cases of celiac disease and 10,750 controls were included in the analysis. The results indicated no significant association between genetic risk factors for cardiovascular disease—such as coronary artery disease or stroke—and the risk of developing celiac disease. This finding suggests that while cardiovascular genetic factors may influence the risk of developing psoriasis, they do not appear to have the same effect on celiac disease or other immune-mediated conditions.

    Understanding the Relationship Between Psoriasis and Cardiovascular Disease

    The discovery that genetic risk factors for cardiovascular disease are linked specifically to psoriasis, but not to other immune-mediated diseases, points to the possibility of a unique shared biological mechanism. Psoriasis is a disease driven by inflammation, and inflammation is also a key factor in the development of cardiovascular diseases like coronary artery disease and stroke. However, the study’s findings suggest that this connection may not extend to all immune-mediated diseases, challenging previous assumptions about the broad relationship between cardiovascular disease and inflammation-driven conditions.

    One possible explanation for this connection could lie in the specific inflammatory pathways involved in both cardiovascular disease and psoriasis. Psoriasis is known to involve certain inflammatory cellular and cytokine pathways, and these same pathways may play a role in the development of cardiovascular disease. However, these pathways may not be as significant in other immune-mediated diseases, which could explain the lack of genetic association with conditions like rheumatoid arthritis and inflammatory bowel disease.

    Implications for Treatment and Future Research

    The findings of this study have several important implications. First, they highlight the need for further research into the shared genetic mechanisms underlying cardiovascular disease and psoriasis. Understanding these mechanisms could lead to the development of new treatments that target both conditions. For example, therapies that reduce inflammation in psoriasis patients could potentially help lower their risk of cardiovascular disease, and vice versa.

    Second, the study underscores the importance of personalized medicine. As more is learned about the genetic links between different diseases, it becomes increasingly possible to develop tailored treatments that address an individual's unique genetic risk factors. For patients with psoriasis who are also at risk for cardiovascular disease, this could mean more targeted interventions that address both conditions simultaneously.

    Implications for Those with Celiac Disease

    The study’s findings highlight the importance of understanding the genetic overlap between cardiovascular disease and psoriasis, but they also underline the distinction when it comes to celiac disease. For those with celiac disease, the results are reassuring as they show no genetic link between cardiovascular risks and the condition. This separation emphasizes that while shared inflammatory pathways may exist between certain immune-mediated diseases and cardiovascular disease, celiac disease does not appear to be influenced by these cardiovascular genetic factors. As such, this research may provide a better understanding of how different immune-mediated diseases interact with cardiovascular health, guiding future research and treatment strategies.

    Read more at: jamanetwork.com


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    Brian C. Comstock

    How come no one's talking about the connection between tainted GMO wheat pollen spreading around the globe in contaminating the entire Global wheat Supply? Isn't that the real cause of celiac? Shouldn't there be the largest class action suit in history in the process? They told us they were trying to change the genetic code of wheat in order to grow in harsher climates like Africa. Seems kind of obvious that this might affect the protein structure... no one is talking about it. I find that highly suspect.

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    trents
    8 minutes ago, Brian C. Comstock said:

    How come no one's talking about the connection between tainted GMO wheat pollen spreading around the globe in contaminating the entire Global wheat Supply? Isn't that the real cause of celiac? Shouldn't there be the largest class action suit in history in the process? They told us they were trying to change the genetic code of wheat in order to grow in harsher climates like Africa. Seems kind of obvious that this might affect the protein structure... no one is talking about it. I find that highly suspect.

    No, it can't be the real cause of celiac disease because celiac disease existed long before genetic modification technology existed. There is historical evidence of the existence of celiac disease from ancient times. Please provide links to support your claims and ideas about GMO wheat pollen "contaminating the entire Global wheat Supply" and being "the real cause of celiac".

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    Scott Adams
    27 minutes ago, Brian C. Comstock said:

    How come no one's talking about the connection between tainted GMO wheat pollen spreading around the globe in contaminating the entire Global wheat Supply? Isn't that the real cause of celiac? Shouldn't there be the largest class action suit in history in the process? They told us they were trying to change the genetic code of wheat in order to grow in harsher climates like Africa. Seems kind of obvious that this might affect the protein structure... no one is talking about it. I find that highly suspect.

    Although there are projects to create GMO wheat that won't trigger celiac disease, commercial wheat is not genetically modified (GMO). In fact, there is no approved GMO wheat grown for human consumption anywhere in the world. The primary cause of celiac disease is an autoimmune response to gluten, a protein found naturally in wheat, barley, and rye. This condition has been documented long before modern agricultural practices. While GMO crops exist for other grains like corn and soy, the gluten in wheat has always been the trigger for celiac, unrelated to genetic modification. Claims about GMO wheat causing celiac are not supported by scientific evidence.

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    Brian C. Comstock
    6 hours ago, trents said:

    No, it can't be the real cause of celiac disease because celiac disease existed long before genetic modification technology existed. There is historical evidence of the existence of celiac disease from ancient times. Please provide links to support your claims and ideas about GMO wheat pollen "contaminating the entire Global wheat Supply" and being "the real cause of celiac".

    Listen, I know Celiac existed before they polluted the world's wheat supply with tainted GMO pollen released into the wild with out any concern. They did, it is a fact.  Big IQ test here.  Suddenly the tendency of Celiac began exploding after the 1990s. You can look up the statistics.  Something previously rare and thought to be exclusively genetic, suddenly starts rising exponentially?  Might there be an aggravating factor introduced? 20 years ago, there was no talk about gluten.  No one knew what gluten was.  There were no isles in the grocery stores for "gluten-free" products. No jokes about it in movies. Anyone over the age of 30 should know what I am talking about.  I never said GMO wheat was the singular cause of Celiac.  I specifically stated it seems to correlate directly with the MASSIVE INCREASE in Celiac cases world wide. I do not need to provide links.  And neither do you.  Just give me an explanation for the extreme coincidence for the massive rise in Celiac correlating with the release of GMO wheat in the 1990s? A better one than "medical technology for detecting it got better."  Because that is a fallacy.  Medical technology tends to improve by demand.  More people showing symptoms means more medical investment... Its is just as easily further evidence of the correlation.

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    knitty kitty
    4 hours ago, Brian C. Comstock said:

    Just give me an explanation for the extreme coincidence for the massive rise in Celiac correlating with the release of GMO wheat in the 1990s?

    I never said GMO wheat was the singular cause of Celiac.  I specifically stated it seems to correlate directly with the MASSIVE INCREASE in Celiac cases world wide. 

     

    The use of Microbial Transglutaminase as a food additive, used in baked goods, dairy products, and processed foods since 1989, has increased rapidly.   Microbial transglutaminase has been found to be an agent that triggers Celiac Disease.  

    High fructose corn syrup was introduced in the 1970's as a cheaper alternative to sugar.  

    High fructose corn syrup in the digestive tract provides a mesh that colonic bacteria use to climb into the small intestine.  Small Intestinal Bacterial Overgrowth, SIBO, results in inflammation,  leaky gut syndrome, and nutritional deficiencies.  The bacteria compete with the human to absorb essential vitamins, like Thiamine.  Gut dysbiosis is a trigger for Celiac Disease.

    Non Alcoholic Fatty Liver Disease (now called NASH) has increased epidemically since high fructose corn syrup was introduced.  High fructose corn syrup has to be processed through the liver, just like alcohol.  The liver uses Thiamine to process both high fructose corn syrup and alcohol.  If there's not sufficient Thiamine, the liver becomes filled with fat deposits.  

    A Western diet is loaded with carbohydrates.  When a diet high in carbohydrates is consumed, there is an increased demand for Thiamine (and the other B vitamins).  Gluten containing products are required to have vitamins added to them.  Unfortunately, food manufacturers add shelf stable forms (like thiamin mononitrate) that the human body doesn't absorb nor utilize well.  This results in High Calorie Malnutrition, where there's sufficient calories, but insufficient vitamins needed, so the excess calories are stored as fat.  Obesity is another global epidemic.  

    Thiamine Deficiency Disorders are on the rise globally as more foreign countries reject traditional diets and adopt a Western diet, replete with high fructose corn syrup, gut dysbiosis, microbial transglutaminase, obesity and High Calorie Malnutrition.

    When there is a Thiamine deficiency inside a cell, the autoimmune disease genes get turned on, activating Celiac Disease and other autoimmune disease genes, too.  

    Thiamine is destroyed by heat and sunlight.  Global Warming is causing thiamine deficiency in wildlife.  Fish, birds and plants are being affected.  Our crops and livestock are being affected, too, so I'm not really worried about "FrankenWheat" any more.

    Edited by knitty kitty
    Typo correction
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    Scott Adams
    13 hours ago, Brian C. Comstock said:

    I never said GMO wheat was the singular cause of Celiac.  I specifically stated it seems to correlate directly with the MASSIVE INCREASE in Celiac cases world wide. I do not need to provide links.  And neither do you.  Just give me an explanation for the extreme coincidence for the massive rise in Celiac correlating with the release of GMO wheat in the 1990s? A better one than "medical technology for detecting it got better."  Because that is a fallacy.  Medical technology tends to improve by demand.  More people showing symptoms means more medical investment... Its is just as easily further evidence of the correlation.

    Wheat has not been genetically modified (GMO) for commercial use. Though research has been conducted on GMO wheat, it has not been approved or widely grown for a few key reasons. First, wheat is a major export crop, and many of the countries importing U.S. wheat do not accept GMO crops, which would affect trade. Additionally, there isn't strong consumer demand for GMO wheat within the U.S., reducing the incentive to produce it. This means that any wheat products labeled as "non-GMO" in the U.S. are essentially accurate by default, as there is no commercially available GMO wheat.

    For more information, you can check sources like the Non-GMO Project, the U.S. Department of Agriculture, and the Whole Grains Council for details about GMO policies and the status of wheat production.

    Sources:

    Non-GMO Project (nongmoproject.org)

    U.S. Department of Agriculture (ers.usda.gov)

    Whole Grains Council (wholegrainscouncil.org)

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    Brian C. Comstock

    Once again I get a deliberately obtuse and misleading response along with a warning and a strike...  It seems someone has an interest in running interference for those who have something to lose if the truth about the world's wheat having been tainted by GMO pollen where to get attention. 

    I do not need to provide links.  Fallacious demand.   I just need to illustrate the logic and the facts. 
    We all agree they started experimenting with GMOs in the 1950s. Fact. 
    They were advanced enough by the 1990s for them to begin openly breeding their GMO wheat in uncontrolled open environments in places literally covering every corner of the Globe. Fact.
    Pollen is air borne. Fact. It cannot be contained or accounted for. 
    What did they seek to create with their GMO experiments?  Stronger wheat. Fact.
    Wheat that can grow in harsher climates and survive with less water.  They succeeded but for some reason world hunger was not mitigated... 
    Here is the logic.  We all understand Darwin's law of survival of the fittest, right? They created a strain of stronger wheat. They released that pollen unbridled into the environment all over the globe. Fact. 
    What happens in Darwinism when a stronger gene is introduced into the gene pool?  It takes over the gene pool given enough time and exposure.  It took 20 years to contaminate the worlds wheat crops enough to begin showing clear statistical correlation in the dramatic rise in Celiac sensitivity.

    Or else it is one whopper of a coincidence and I sure would like you to attempt an explanation for that coincidence instead of running interference and trying to silence me with intimidation tactics.

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    trents

    As myself and others have pointed out, your use of the term GMO is flawed. GMO technology was not available in the 1950s.

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    Scott Adams
    10 hours ago, Brian C. Comstock said:

    Once again I get a deliberately obtuse and misleading response along with a warning and a strike...  It seems someone has an interest in running interference for those who have something to lose if the truth about the world's wheat having been tainted by GMO pollen where to get attention. 

    I do not need to provide links.  Fallacious demand.   I just need to illustrate the logic and the facts. 
    We all agree they started experimenting with GMOs in the 1950s. Fact. 
    They were advanced enough by the 1990s for them to begin openly breeding their GMO wheat in uncontrolled open environments in places literally covering every corner of the Globe. Fact.
    Pollen is air borne. Fact. It cannot be contained or accounted for. 
    What did they seek to create with their GMO experiments?  Stronger wheat. Fact.
    Wheat that can grow in harsher climates and survive with less water.  They succeeded but for some reason world hunger was not mitigated... 
    Here is the logic.  We all understand Darwin's law of survival of the fittest, right? They created a strain of stronger wheat. They released that pollen unbridled into the environment all over the globe. Fact. 
    What happens in Darwinism when a stronger gene is introduced into the gene pool?  It takes over the gene pool given enough time and exposure.  It took 20 years to contaminate the worlds wheat crops enough to begin showing clear statistical correlation in the dramatic rise in Celiac sensitivity.

    Or else it is one whopper of a coincidence and I sure would like you to attempt an explanation for that coincidence instead of running interference and trying to silence me with intimidation tactics.

    There is no wheat GMO pollen contaminating anything, because commercial wheat is not GMO. It would take too long to debunk all of what you believe to be facts in this post, but given that your entire premise, that wheat is a GMO is incorrect, there is no need for me to waste my time.

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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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