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    Scott Adams
    Scott Adams

    Untreated Celiac Disease not Associated with Poor Birth Outcome

    Reviewed and edited by a celiac disease expert.

    Gut. 2004 Jan;53(1):149-51

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    Celiac.com 12/31/2003 – Italian researchers report in the journal Gut that their previous hypothesis which was based on their hospital study that reported a 1 in 80 incidence of celiac disease in pregnant women and an unfavorable pregnancy outcome for them needs to be revised. With the goal of proving their initial research the group conducted a "large population based study on a stratified sample from the whole Campania region" in Italy. The study looked at 5,055 pregnant women and tested them for IgA class anti-tissue transglutaminase (TGASE) antibodies using the ELISA method. In addition "Endomysial antibodies (EMA) were investigated on thin sections of human cord blood by an immunofluorescence test. The HLA class II DQA1*0501/DQB1*02 and DQA1*0301/DQB1*0302 haplotypes were assessed using the Eurospital Eu-DQ kit."

    The researchers found that 51 of the 5,055 patients tested positive for celiac disease, and 12 women with known celiac disease were added to the results which yielded a ratio of 1 in 80 pregnant women with celiac disease, results that matched the groups first study. When the celiac-positive groups birth outcomes were compared with the normal group the researchers did "not observe an excess risk of abortion, premature delivery, small birth weight, or intrauterine growth retardation," although anemia was more frequent in the celiac disease group.

    The researchers conclude that "undiagnosed coeliac disease is frequent among pregnant women (>1%) but is not associated with an unfavorable outcome of pregnancy."



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  • About Me

    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.


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