Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    What's the Connection Between Infection, Antibiotic Exposure, and Celiac Disease Risk?

    Reviewed and edited by a celiac disease expert.

    New study shows that early infection and/or antibiotic exposure increase the odds of developing celiac disease.

    What's the Connection Between Infection, Antibiotic Exposure, and Celiac Disease Risk? - Image: CC BY-SA 2.0--Pitel
    Caption: Image: CC BY-SA 2.0--Pitel

    Celiac.com 12/26/2019 - Earlier studies have suggested a relationship between infection, associated antibiotic exposure, and the risk of celiac disease. However, there hasn't been a comprehensive evaluation of those studies that might help to deliver a clear answer.

    To address this, a team of researchers recently conducted a meta-analysis to investigate the relationship between infection, associated antibiotic exposure, and celiac disease risk.

    Celiac.com Sponsor (A12):
    They began looking for relevant studies by searching the PubMed, Embase, and Cochrane databases for articles published through April 2019. They used random effects models to determine overall pooled estimates and 95% confidence intervals (CIs). 

    Their meta-analysis contained 19 observational studies, including 15 on infection and six on antibiotic exposure. They found that any infection was associated with an increased risk of celiac disease later in life. The heterogeneity among studies was high enough to put the I2 at 94%.

    An analysis of subgroups indicates that celiac risk is independent of infection type, timing of exposure, or site of infection. Antibiotic exposure was also associated with new celiac disease cases. 

    These results provide strong evidence that early infection and/or antibiotic exposure increase the odds of developing celiac disease, and suggest that disruption of intestinal immune processes or gut microbiota may play a role in celiac disease development. 

    These findings could eventually influence clinical treatment and help to prevent celiac disease. Certainly, the rise of antibiotic use to treat infections mirrors the rise in cases of celiac disease over the last six or seven of decades.

    However, further study is needed to fully eliminate non-causal explanations for these connections. That is, they haven't fully discounted the possibility that there is another cause for the connection. Stay tuned for more developments on this and related stories.

    Read more at: wiley.com

     

    The research team included Hai-yin Jiang, Xue Zhang, Yuan-yue Zhou, Chun-min Jiang, and Yu-dan Shi. They are variously affiliated with the Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, the Department of Child Psychiatry, Hangzhou Seventh People’s Hospital,  Department of Pediatrics, The Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou and Department of Chinese Internal Medicine, Taizhou First People’s Hospital, Taizhou, China.



    User Feedback

    Recommended Comments

    sc'Que?

    I would like someone to better explain the interplay between genetic predispoal to Celiac... in relation/concert to the sort of information in this article. It is very confusing for moderately science-savvy readers to understand where the line between nature and nurture lies.  PLEASE HELP CLARIFY THIS!

    Link to comment
    Share on other sites
    Guest Jill

    This is true for me and my 2 children with Celiac. My other child who doesn’t have Celiac was not as sick as often and didn’t have as many antibiotics prescribed either. My oldest is 20 and I wish MD would’ve told me the importance of probiotics. 

    Link to comment
    Share on other sites
    Guest Ida

    I don't understand. I don't think you can just develop celiac disease later in life because of antibiotics. You need to be born with the gene in order for celiac to develop

    Link to comment
    Share on other sites
    Ging
    10 hours ago, sc'Que? said:

    I would like someone to better explain the interplay between genetic predispoal to Celiac... in relation/concert to the sort of information in this article. It is very confusing for moderately science-savvy readers to understand where the line between nature and nurture lies.  PLEASE HELP CLARIFY THIS!

    This page might help with understanding the conflict in the possible causes/understanding of Celiac and it's triggers and/or development.

    Open Original Shared Link

    At one point, under the 'Causes' drop down, the article states:

    " Almost all people with celiac disease have specific variants of the HLA-DQA1 and HLA-DQB1 genes, which seem to increase the risk of an inappropriate immune response to gliadin. However, these variants are also found in 30 percent of the general population, and only 3 percent of individuals with the gene variants develop celiac disease. "

    So, part gene, part environment, part other factors... .  I think no one is sure yet, but the study mentioned in the article we're responding to (connection to antibiotics, etc) is very broad and still extremely early to draw any conclusions.  It's a rare person that hasn't had an infection or some antibiotic treatment these days - we don't all have Celiac, though.

    Link to comment
    Share on other sites


    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Is a Reovirus Infection a Prime Cause of Celiac Disease?
    Celiac.com 04/17/2017 - A team of researchers recently set out to test this hypothesis and to gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens. To do so, they developed a viral infection model that makes use of two reovirus strains that infect the intestine, but which differ in their immunopathological outcomes.
    The research team included Romain Bouziat, Reinhard Hinterleitner, Judy J. Brown, Jennifer E. Stencel-Baerenwald, Mine Ikizler, Toufic Mayassi, Marlies Meisel, Sangman M. Kim, Valentina Discepolo, Andrea J. Pruijssers, Jordan D. Ernest, Jason A. Iskarpatyoti, Léa M. M. Costes, Ian Lawrence, Brad A. Palanski, Mukund Varma, Matthew A. Zurenski, Solomiia Khomandiak, Nicole McAllister, Pavithra Aravamudhan, Karl W. Boehme, Fengling Hu, ...


    Jefferson Adams
    Is There a Connection Between Antibiotic Use and Celiac Disease Autoimmunity?
    Celiac.com 11/07/2017 - Researchers still don't have much good data on the consequences of antibiotic use in early life and how that relates to the risk of certain autoimmune diseases.
    A team of researchers recently set out to test the association between early-life antibiotic use and islet or celiac disease autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or celiac disease. Their study is part of a larger study called The Environmental Determinants of Diabetes in the Young, or TEDDY, for short.
    The reasearch team enrolled HLA-genotyped newborns from Finland, Germany, Sweden, and the United States between November 20, 2004, and July 8, 2010, and analyzed data from November 20, 2004, to August 31, 2014.
    They also enrolled individuals...


    Jefferson Adams
    Enterovirus Infection in Childhood Could Trigger Celiac Disease
    Celiac.com 02/18/2019 - Many researchers have suspected that childhood infections with certain viruses may open the door for the development of celiac disease. Celiac.com has covered the connection in previous articles, such as Can Viruses Trigger Celiac Disease? and Is a Reovirus Infection a Prime Cause of Celiac Disease? Now there is even more evidence to support such a connection.

    A team of Norwegian researchers recently set out to learn whether early exposure to common intestinal viruses, specifically human enterovirus or adenovirus, are factors in the later development of celiac disease.
    The research team included Christian R Kahrs,  Katerina Chuda,  German Tapia,  Lars C Stene,  Karl Mårild,  Trond Rasmussen,  Kjersti S Rønningen,  Knut E A Lundin,  Lenka Kramna,...


    Jefferson Adams
    Study Connects Antibiotics in First Year of Life with Celiac Disease
    Celiac.com 03/11/2019 - Many researchers believe that intestinal microbiota play a key role in the development of celiac disease. Since gut microbiota are strongly influenced by systemic antibiotics, especially in early life, the role of antibiotics in the development of celiac disease comes into question. Do antibiotics in infancy influence celiac disease rates later on?
    The team’s observational nationwide register-based cohort study included all children born in Denmark from 1995 through 2012, and Norway from 2004 through 2012. They followed the children born in Denmark until May 8, 2015 and the children born in Norway until December 31, 2013. 
    In all, they gathered medical data on more than 1.7 million children, including 3,346 with a diagnosis of celiac disease. Any pa...


  • Recent Activity

    1. - Wheatwacked replied to Dhruv's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      20

      Confused with test results

    2. - trents replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      12

      Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos

    3. - Elliebee replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      12

      Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos

    4. - Scott Adams replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      12

      Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos

    5. - trents replied to Elliebee's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      12

      Does Hashimoto’s Hypothyroidism elevate Ttg levels ? I have had 3 blood test results where ttg levels are around 39-43 (range 0-19). The first test was in 2021 before I was diagnosed with autoimmune thyroid disease. I had an endos


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      125,778
    • Most Online (within 30 mins)
      7,748

    Cathy Roth
    Newest Member
    Cathy Roth
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.8k
    • Total Posts
      68.9k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Elliebee
    • mswhis
    • Dhruv
      20
    • Sking
    • jmiller93
      8
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...