Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    Why Do So Few Patients with Non-Celiac Gluten Sensitivity React to Gluten Challenges?

    Reviewed and edited by a celiac disease expert.

    Celiac.com 11/30/2015 - A new study by researchers in Italy shows that only a minority of patients who meet clinical criteria for non-celiac gluten sensitivity actually show symptoms when exposed to gluten in a controlled gluten challenge. Why is that?

    Photo: CC--Dean HochmanResearchers haven't had much good information on whether symptoms in people who meet clinical diagnostic criteria for non-celiac gluten sensitivity (NCGS) are specifically triggered by gluten. To provide better information, a team of researchers recently set out to assess gluten sensitivity in patients diagnosed with NCGS.

    Celiac.com Sponsor (A12):
    The research team includes B. Zanini; R. Basché; A. Ferraresi; C. Ricci; F. Lanzarotto; M. Marullo; V. Villanacci; A. Hidalgo; and A. Lanzini. They are variously affiliated with Department of Gastroenterology, and the Department of Pathology at the University and Spedali Civili of Brescia, Brescia, Italy, and the Department of Food, Environmental and Nutritional Sciences at the University of Milan, Milan, Italy.

    For their in a double-blind challenge study, their team looked at 31 females and 4 males without celiac disease, who were following a gluten-free diet (GFD). Participants were randomly broken into groups that received either gluten-containing flour or gluten-free flour for 10 days, followed by a 2-week washout period, followed by a switch in gluten-free/non-gluten-free diets.

    The main outcome measure was the test subjects' ability to identify which flour contained gluten. Secondary outcome measures were based upon Gastrointestinal Symptoms Rating Scale (GSRS) scores.

    Only 12 participants (34%) classified as having NCGS correctly pointed out the gluten-containing flour. These participants showed much higher average GSRS dimension scores following gluten challenge compared to baseline.

    The team measured scores for: pain, 1.7 ± 0.8 vs. 2.6 ± 1.0; reflux, 1.6 ± 0.5 vs. 2.2 ± 0.9; indigestion, 1.9 ± 0.7 vs. 3.2 ± 1.1; diarrhea, 1.6 ± 0.7 vs. 2.9 ± 1.5 and constipation, 1.9 ± 0.9 vs. 2.9 ± 1.3.

    Seventeen participants, nearly half, erroneously considered the gluten-free flour to contain gluten. Their average GSRS dimension scores were significantly higher following gluten-free flour challenge compared to baseline.

    The scores were: pain, 1.6 ± 0.9 vs. 3.0 ± 0.9; reflux, 1.4 ± 0.5 vs. 2.3 ± 1.1; indigestion, 2.0 ± 1.1 vs. 3.7 ± 1.1; diarrhea, 1.6 ± 0.7 vs. 3.0 ± 1.2 and constipation, 1.6 ± 0.9 vs. 2.6 ± 1.3.

    The other six participants (17%) were unable to distinguish between the flours.

    Based on this study, only about one in three patients with clinical non-celiac gluten sensitivity showed an adverse reaction to gluten.

    Clearly, more needs to be done to determine the exact nature of non-celiac gluten-sensitivity, and to determine what, if anything, may be driving these adverse reactions that can be triggered by non-gluten containing foods.

    Source:

    • Open Original Shared Link


    User Feedback

    Recommended Comments

    Guest Michael

    Posted

    A woman in my CSA group who does not have DQ2 or 8, but rather perhaps 5 and 7 or 9 (can't remember) gets a migraine if eating a salad from which croutons have been removed. Gastroenterologists and people in general need to realize that the effects of gluten are more likely to be neurological than anyplace and more likely to be extra intestinal.

     

    I just met a woman with MS who says she cannot handle some kinds of gluten-free bread, and she is "trying" to be paleo, but did not even know she has to read the ingredients of a turkey, and she is sensitive to coconut.

     

    No wonder the gastroenterologists are confused.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 08/11/2014 - A study establishing the existence of non-celiac gluten sensitivity has been turned on its head; by the very scientist who conducted it. In 2011, a small but scientifically rigorous study found that dietary gluten can trigger gastrointestinal distress in people without celiac disease. That study was conducted by Peter Gibson at Monash University in Australia.
    Last year, Gibson published a follow-up study, which indicated that the real culprit might not be gluten, but fermentable, poorly absorbed short-chain carbohydrates known as FODMAPs. Specifically, Gibson’s second study found no effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. That is, once these a...


    Jefferson Adams
    Non-Celiac Gluten Sensitivity Not Holding Up to Scrutiny
    Celiac.com 08/25/2014 - Numerous people without celiac disease claim to suffer from celiac-like gastrointestinal symptoms when they consume wheat, rye or barley products, and claim that avoiding these products makes them feel better. However, even though many people make this claim, this is largely a self-reported condition. Some data have supported the idea of gluten sensitivity, but the most recent and more complete data seem to indicate that the real culprit might not be gluten, but fermentable, poorly absorbed short-chain carbohydrates known as FODMAPs.
    In fact the same researcher whose early data supported the idea of non-celiac gluten sensitivity also headed the follow-up study that showed no effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary...


    Jefferson Adams
    Celiac.com 03/23/2015 - There's been a bit of ping-ponging going on about the status of non-celiac gluten sensitivity as a valid medical condition. Studies have yielded conflicting results, with some supporting, and others negating, the existence of non-celiac gluten-sensitivity. 
    So what's the deal? Does non-celiac gluten sensitivity exist, or not? Researchers and clinicians continue to debate whether people without celiac disease or wheat allergy who consume gluten can experience intestinal and extra-intestinal symptoms attributable to non-celiac gluten sensitivity (NCGS).
    Taking the latest stab at the problem, a team of researchers recently conducted a randomized, double-blind, placebo-controlled, cross-over trial to determine the effects of administration of low doses of gluten ...


    Jefferson Adams
    Celiac.com 06/11/2015 - Non-celiac gluten sensitivity (NCGS) is a somewhat controversial emerging disorder. There is no current medical consensus regarding its criteria, and study data have been inconclusive.
    Many alternative health practitioners recommend gluten-free diets for people who claim to be sensitive to gluten, but do not have celiac disease. Despite numerous reports of people without celiac disease experiencing celiac-like symptoms when eating gluten, there are currently no clear diagnostic guidelines for NCGS. NCGS is still diagnosed by excluding celiac disease, and finding no reliable celiac biomarkers.
    A team of researchers recently set out to evaluate the prevalence, diagnostic exclusion of celiac disease and the efficacy of a gluten-free diet (GFD) for NCGS patients...


  • Recent Activity

    1. - RMJ replied to Jean Shifrin's topic in Traveling with Celiac Disease
      1

      Implications of glutening after repairing villi

    2. - Jean Shifrin posted a topic in Traveling with Celiac Disease
      1

      Implications of glutening after repairing villi

    3. - Scott Adams replied to Patrick-Tyler's topic in Gluten-Free Restaurants
      5

      Is McDonald's Safe for Gluten-Free Orders?

    4. - trents replied to Patrick-Tyler's topic in Gluten-Free Restaurants
      5

      Is McDonald's Safe for Gluten-Free Orders?

    5. - Scott Adams replied to GeordieGeezer's topic in Food Intolerance & Leaky Gut
      17

      Anybody else have a similar experience...theories welcome as its something which i dont really understand.....


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      125,803
    • Most Online (within 30 mins)
      7,748

    Emeraeld
    Newest Member
    Emeraeld
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.8k
    • Total Posts
      69k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Patrick-Tyler
    • Elliebee
    • mswhis
    • Dhruv
      20
    • GeordieGeezer
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...