Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    By Jefferson Adams •

    Why Some High-risk Individuals Develop Celiac Disease and Others Do Not

    Reviewed and edited by a celiac disease expert.

    Celiac.com 06/11/2009 - Specialty pharmaceutical and diagnostic company, Prometheus Laboratories Inc., announced new findings regarding a correlation between an important serologic marker used in the detection of Crohn's disease and particular genetic markers in patients at risk for celiac disease.

    Using proprietary Prometheus technology, researchers analyzed blood and serum samples from 5,406 patients at risk for celiac disease who are EMA positive. Results showed a significant correlation between antibodies to the flagellin CBir1 and HLA haplotypes DQ2.5 and DQ8.

    Celiac.com Sponsor (A12):
    They found that an overly aggressive immune response to particular bacteria in the intestine, as in Crohn's disease, may contribute to the inflammation seen in patients with celiac disease.

    Relatively few susceptible individuals "actually develop the disease, despite gluten ingestion, for reasons that are not well understood," said Dr. Michelle Pietzak, a Pediatric Gastroenterologist in the Division of Gastroenterology at the University of Southern California Keck School of Medicine. Research like this is helping us figure out the answers to those questions.

    Source: Open Original Shared Link

     Share
    Go to articles

    User Feedback

    Recommended Comments

    There are no comments to display.



    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate

  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Related Articles

    Kim Hopkins
    Celiac.com 06/05/2009 - Recently, the British Journal of Nutritionreported that following a gluten-free diet may be detrimental to guthealth, which may also affect immune health, according to a new studyfrom the Spanish National Research Council. The Spanish researchersanalyzed the gut microflora of ten healthy subjects with an average ageof 30 assigned to consume a gluten-free diet for one month.   Analysisof the participants’ feces showed that populations of healthy gutbacteria decreased following the gluten-free diet, while populations ofunhealthy bacteria increased.

    It has been previously documented that gluten can cause leaky gut, evenwithout celiac disease.  Chronic gluten exposure has been shown toactivate zonulin resulting in increased intestinal permeability (orleaky gut)...
    Jefferson Adams
    Celiac.com 08/06/2009 - A study by a team of Spanish researchers puts the world on notice that gluten may trigger adverse reactions in both celiacs and non-celiacs alike. The research team was made up of E. Arranz, D. Bernardo, L. Fernandez-Salazar, J. A. Garrote and their colleague S. Riestra, all doctors based in Spain.
    According to the current medical wisdom, innate immunity to gluten plays a critical role in the development of celiac disease (celiac disease).
    This innate immune response is caused by a reaction to the ‘toxic’ gluten peptides that is mediated by interleukin (IL) 15, like the 19-mer through a DQ2-independent mechanism, and which causes epithelial stress and triggers the intraepithelial lymphocytes to turn into natural killer (NK)-like cells, which then causes ent...
    Jefferson Adams
    No Link Between Early Psychological Stress and Later Celiac Disease
    Celiac.com 12/15/2010 - A small study in Swedish children has found no association between early childhood psychological stress and later development of celiac disease. Previous studies have shown links between psychological stress and a number immunological diseases, such as inflammatory bowel disease.
    A team of researchers sought to look more closely at the connection between psychological stress in families and biopsy-proven celiac disease in children. The team included Karl Mårild, Anneli Sepa Frostell, and Jonas F. Ludvigsson.
    Their measure of psychological stress included factors such as serious life events, parenting stress, and parental worries. Using a questionnaire data from the ABIS study (All Babies In southeast Sweden), the team collected data on 11,000 children at ...
    Jefferson Adams
    Can Online Intervention Help Improve Gluten-free Diet Adherence in Adults with Celiac Disease?
    Celiac.com 05/08/2013 - A team of researchers recently set out to test determine if an interactive online intervention might help to improve gluten free diet adherence in adults with celiac disease.
    The research team included Kirby Sainsbury BA/BEd, DCP (candidate), Barbara Mullan PhD and Louise Sharpe PhD. They are affiliated with the School of Psychology, and the Clinical Psychology Unit at the University of Sydney in Sydney, New South Wales, Australia
    For their controlled trial, the researchers recruited 189 adults with biopsy-confirmed celiac disease. They randomly assigned 101 adults to receive the intervention, and 88 adults to a wait-list control condition.
    They retrieved post-intervention data for 70 intervention subjects and 64 wait-list participants, along with three...

  • Recent Activity

    1. knitty kitty
      - knitty kitty replied to Bindi's topic in Super Sensitive People
      38

      Refractory or super sensitive?

      @glucel, I agree with @trents. You can still do the AIP diet while taking aspirin. I'm one of those very sensitive to pharmaceuticals and have gotten side affects from simple aspirin. Cardiac conduction abnormalities and atrial arrhythmias associated with salicylate toxicity https://pubmed.ncbi.nlm.nih.gov/3952006/ Another part...
    2. Wheatwacked
      - Wheatwacked replied to pasqualeb's topic in Related Issues & Disorders
      14

      Muscle atrophy in legs

      Polymyositis is a rare autoimmune disease that makes your immune system attack your muscles. Any autoimmune disease is associated with low vitamin D. Even as a kid I had weak legs. Now I feel the burn just walking to the mailbox. A case-control study found that patients with polymyositis (PM) had higher lactate levels at rest and after...
    3. Wheatwacked
      - Wheatwacked replied to aperlo34's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      3

      2 months in... struggling with symptoms

      Micronutrient Inadequacies in the US Population "A US national survey, NHANES 2007-2010, which surveyed 16,444 individuals four years and older, reported a high prevalence of inadequacies for multiple micronutrients (see Table 1). Specifically, 94.3% of the US population do not meet the daily requirement for vitamin D, 88.5% for vitamin E, 52.2% for...
    4. Wheatwacked
      - Wheatwacked replied to Bindi's topic in Super Sensitive People
      38

      Refractory or super sensitive?

      The paleo diet is based on the idea that the human body evolved to consume a balanced ratio of omega-6 and omega-3 fatty acids, and that the modern diet is out of balance. A healthy ratio of omega-6 to omega-3 is 1:1–4:1, while the modern diet is closer to 20:1–40:1. The paleo diet aims to restore this balance.
    5. Wheatwacked
      - Wheatwacked replied to Savannah Wert's topic in Coping with Celiac Disease
      3

      Hey all!

      Best thing you can do for them! First-degree family members (parents, siblings, children), who have the same genotype as the family member with celiac disease, have up to a 40% risk of developing celiac disease. Make sure you and they get enough vitamin D and iodine in their diet. Iodine deficiency is a significant cause of mental developmental...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      125,961
    • Most Online (within 30 mins)
      7,748
    MaryEH
    Newest Member
    MaryEH
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.1k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Popular Now

    • Dawn R.
      4
      Gluten Ataxia

      By Dawn R.
      Started

    • jadeceoliacuk
      5
      How to choose a Naturopath for 6yr old

      By jadeceoliacuk
      Started

    • pasqualeb
      14
      Muscle atrophy in legs

      By pasqualeb
      Started

    • Bindi
      38
      Refractory or super sensitive?

      By Bindi
      Started

    • Jordan Carlson
      8
      Raw Meat Craving

      By Jordan Carlson
      Started

  • Popular Articles

    • Scott Adams
      60
      The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free

      By Scott Adams

    • Scott Adams
      78
      Forbidden Gluten Food List (Unsafe Ingredients)

      By Scott Adams

    • Scott Adams
      66
      Safe Gluten-Free Food List (Safe Ingredients)

      By Scott Adams

    • Scott Adams
      144
      What Are the Symptoms of Celiac Disease?

      By Scott Adams

    • Scott Adams
      72
      Gluten-Free Alcoholic Beverages

      By Scott Adams

  • Upcoming Events

×
×
  • Create New...