Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    Would You Try a Vaccine for Celiac Disease?

    Reviewed and edited by a celiac disease expert.
    Would You Try a Vaccine for Celiac Disease? - Photo: CC--Frank Balsinger
    Caption: Photo: CC--Frank Balsinger

    Celiac.com 08/26/2016 - News that ImmusanT company is beginning full human trials for their celiac disease vaccine, NexVax 2, brought a number of comments from our readers.

    We first reported on their effort way back in 2002, with our story, Australian Researchers Begin Work on a Vaccine for Celiac Disease.

    Celiac.com Sponsor (A12):
    We followed up over the years, with stories in 2009, First Ever Celiac Disease Vaccine Trials Underway in Australia and again in 2011, with articles reporting on the company's efforts to raise investment funds, titled ImmusanT Raises $20 Million in Series A Financing to Advance Immunotherapeutic and Diagnostic for Celiac Disease and on how ImmusanT's Celiac Vaccine Passed Phase I Clinical Trials and in 2012, with Is a Vaccine for Celiac Disease Just Around the Corner?

    Comments generally ran toward the affirmative side, with many people expressing excitement or interest in such a vaccine.

    From Jared M: I hope this research goes well. The bread, crackers and pizza I can live without. But I would really like to be able to drink a good IPA again. The sorghum beers are horrible. I am quickly growing tired of ciders. I would definitely pay for this treatment if it works.

    From Toni: I have celiac. That [a vaccine] would be wonderful.

    From Traci: I would like to be involved in a study for this immunization.

    From Linda Haas: Can't wait to hear more about the progress made on this vaccine...it sounds very promising!

    From Donda: I'm thrilled with the possibility of this coming to market.

    From Muriel Weadick: This is what all celiacs have been waiting for, and I am sure I am not alone in wishing the company success.

    From Suzanne: A vaccine like this would make it easier to eat out and go on vacation.

    Jeanne Burge wrote: I would gladly volunteer for the trials in the US. Hope this works!

    Still, a few comments ran toward the less than glowing side, with some people expressing trepidation, or outright distrust toward such a vaccine.

    From Cathi: My Question is, "What will be the side effects of this turning off the body's ability to fight Gluten?" Will there still be destruction some place else and maybe worse? So, many times a pill is created to help one thing only to find out that it created another problem some place else in the body. Frankly, I am worried.

    From Donna: Absolutely agree with you, Cathi. There is always a problem and side effects with ANY drug! My question is this - WHAT ELSE will be shut off? Will we be even MORE susceptible to other illnesses? I am worried as well!

    From Balm: Thanks but no thanks. I'll remain a celiac and continue to eat healthy. While trying to fix one problem, some will end up with far worse problems.

    From Jonnys: Stupid idea! Just another way to make more money off of people.

    Certainly, those who may have a weakened or compromised immune system should consult with a physician before receiving most vaccines. But, in adults with a healthy immune system, such a vaccine would likely present little or no danger to the recipient. Most people with celiac disease have healthy immune systems, so the likelihood of any adverse reaction will be slight.

    Of course, this is all theoretical, even at this point, as vaccine trials have so far not proven how well the vaccine actually works in preventing or curing celiac disease.

    So, the question is, if such a vaccine is proven safe and effective, would you be open to trying it, or not?



    User Feedback

    Recommended Comments



    Guest Julie Mackay

    Posted

    Gee I would gladly try it. I wish I'd been in the trials, I'm so keen. I'd do just about anything at the thought of alleviating this rotten neuropathy and muscle /joint pain, extreme fatigue (9 months diagnosed celiac disease), so possibly still recovering /repairing.

    Link to comment
    Share on other sites
    Guest PhilW

    Yep. If they get good results from the trials, I'll try it. Cross-contamination is getting to be an issue for me. Really don't want to live like a hermit and I do miss my beer.

    Since the vaccine has to be taken on an ongoing basis, you can always stop using it. The vaccine is establishing a tolerance to dietary gluten via the peptides -

     

    "It is specific for celiacs with the HLA-DQ2 haplotype, accounting for about 90% of celiac patients. Nexvax2 encompasses these three proprietary peptides, presenting them to T cells in the absence of a second, T-cell stimulatory signal. T cell recognition of the HLA-DQ2 bound toxic peptides thus occurs in a non-inflammatory environment, establishing tolerance to dietary gluten. This peptide based approach has been successful in generating tolerance in people with cat-sensitive asthma, and has not been used more broadly because it has been difficult to identify the correct toxic epitopes."

    Link to comment
    Share on other sites
    Guest Laurie

    Yes please! I'm in Oregon and I'd LOVE to try it!

    Link to comment
    Share on other sites
    Guest murwared

    Posted

    Yep. If they get good results from the trials, I'll try it. Cross-contamination is getting to be an issue for me. Really don't want to live like a hermit and I do miss my beer.

    Since the vaccine has to be taken on an ongoing basis, you can always stop using it. The vaccine is establishing a tolerance to dietary gluten via the peptides -

     

    "It is specific for celiacs with the HLA-DQ2 haplotype, accounting for about 90% of celiac patients. Nexvax2 encompasses these three proprietary peptides, presenting them to T cells in the absence of a second, T-cell stimulatory signal. T cell recognition of the HLA-DQ2 bound toxic peptides thus occurs in a non-inflammatory environment, establishing tolerance to dietary gluten. This peptide based approach has been successful in generating tolerance in people with cat-sensitive asthma, and has not been used more broadly because it has been difficult to identify the correct toxic epitopes."

    I have celiac disease and I am 13 years old... is there is any vaccine for celiac? If yes where did we can get it and how much is that?

    Link to comment
    Share on other sites
    Guest Tammy

    A vaccine would be a prayer come true! To be able to travel and not worry about where to eat would be freedom. I would most certainly try it.

    Link to comment
    Share on other sites
    Guest Jeffrey W. Adams

    Posted

    I agree what is wrong with going back to growing wheat and others that have not been genetically altered to produce MORE . Then we would not have this problem. I will not take the vaccine.

    Currently, commercial wheat is NOT genetically modified. All strains of commercial wheat currently available were created through standard hybridization techniques.

    Link to comment
    Share on other sites
    Guest Jeffrey W. Adams

    Posted

    I do not believe you have stated if this vaccine is for people with celiac disease or only to keep people without it from getting the disease?

    The vaccine is designed to inoculate people who currently have the disease, desensitizing them so that no adverse gluten reaction took place.

    Link to comment
    Share on other sites
    Guest Jeffrey W. Adams

    Posted

    No vaccines, period!

    Are you in favor of smallpox, diphtheria, polio, measles, and the myriad other diseases that have killed and crippled millions of people over the centuries? Should we just let those go unchecked?

    Link to comment
    Share on other sites
    Guest Jefferson Adams

    Posted

    Seeing as vaccines in general don't work....no. I wouldn't put this crap in my or my child's body.

    Vaccines "don't work?" Do you have any idea the number of people who no longer die from smallpox, diphtheria, polio, measles, and the myriad other diseases that have killed and crippled millions of people over the centuries? Vaccines do, in fact, "work." Open Original Shared Link

    Link to comment
    Share on other sites
    Guest Brent

    Would love a cure for coeliac diease. I am one of those people who are very sensitive and even the smallest amount of gluten makes me violently ill. I wouldn't eat gluten full time though. Would be good to have options again and not get ill from that I eat and can enjoy traveling more without worry.

    Link to comment
    Share on other sites



    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 03/30/2012 - A company called Microtest Laboratories is manufacturing doses of what they claim may be the first effective vaccine treatment for celiac disease. At this point, the only treatment for celiac disease is to avoid gluten in the diet.
    Other companies are working on vaccines for celiac disease, and several working trials are underway. However, this new drug's creator, ImmusanT, based in Cambridge says that, unlike other vaccines, which prevent an infection, their drug, Nexvax2 works by changing the immune system so it no longer attacks gluten.
    Production on Nexvax2, began last week, Steven G. Richter, Microtest’s president and science director, told a local reporter. So far, ImmusanT has raised $20 million in investor capital to bring the vaccine to market. ...


    Jefferson Adams
    How Close Are New Celiac Disease Treatments?
    Celiac.com 04/10/2015 - Of course, a strict gluten free diet is still the only safe and effective treatment for celiac disease. However, new drugs in development, some of which are currently being tested on humans, might allow people with celiac disease to safely eat gluten again, at least in small amounts.
    To be fair, even if all goes smoothly, it will be a few years at least before we see such treatments on the market. Moreover, even though many early results have been encouraging, none have yet entered safety trials, the final step before Food and Drug Administration approval and commercial availability.
    Drugs currently under trial include an enzyme that splits the protein in wheat that triggers adverse reactions, into smaller harmless products, and another which promises...


    Jefferson Adams
    Celiac.com 07/25/2016 - Celiac disease is one of the most common immune-mediated diseases. Often, a gluten-free diet does not fully control celiac symptoms and disease activity.
    Even though no new therapies have been approved, a growing effort, coupled with a rapidly expanding knowledge of the regulatory pathway could soon lead to new breakthroughs.
    A team of researchers recently reviewed the epidemiology, pathophysiology, and current treatment paradigm for celiac disease. The researchers were M Wungjiranirun, CP Kelly, and DA Leffler, both of the Division of Gastroenterology at the Celiac Center of Beth Israel Deaconess Medical Center in Boston, Massachusetts, USA.
    They also reviewed the major types of therapies being proposed for celiac treatment, and expounded broadly upon...


    Jefferson Adams
    Celiac.com 07/19/2016 - The world's first vaccine aimed at curing celiac disease is slated to begin full trials later this year, and residents of the Australian state of Victoria will be among the first humans to give it a try against celiac disease.
    The vaccine, called Nexvax2, was developed by Australian scientist Dr Bob Anderson, and is aimed at giving celiac patients a chance to overcome their immune reaction to the gluten found in products containing wheat, rye and barley. Nexvax2 aims to de-sensitise patients to three peptides contained in gluten that trigger a damaging reaction in their immune system.
    Previous trials on 150 patients from Melbourne, Perth, Adelaide, Brisbane and Auckland were aimed at finding a safe dosage rather than assessing its ability to beat celiac disease...


  • Recent Activity

    1. - jmiller93 replied to jmiller93's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      What do my test results mean?

    2. - knitty kitty replied to jmiller93's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      What do my test results mean?

    3. - knitty kitty replied to HWB's topic in Related Issues & Disorders
      16

      strange symptoms/ diagnosis accuracy

    4. - Wheatwacked replied to HWB's topic in Related Issues & Disorders
      16

      strange symptoms/ diagnosis accuracy

    5. - sh00148 posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      0

      Nighttime Soiling (5 year old)


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      125,734
    • Most Online (within 30 mins)
      7,748

    Allana
    Newest Member
    Allana
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.8k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • jmiller93
      6
    • MomofGF
    • Louise Broughton
      4
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...