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Recent Activity
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- trents replied to Skg414228's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms8Does High DGP IGA Typically Mean Celiac?
No, you don't necessarily need multiple testing methods to confirm celiac disease. There is an increasing trend for celiac diagnoses to be made on a single very high tTG-IGA test score. This started in the UK during the COVID pandemic when there was extreme stress on the healthcare system there and it is spreading to the US. A tTG-IGA score of somewhere between... -
- Skg414228 replied to Skg414228's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms8Does High DGP IGA Typically Mean Celiac?
Okay yeah that helps! To answer your last bit my understanding was that you need to have multiple tests to confirm celiac. Blood, biopsy, dna, and then I think symptoms is another one. Either way I think everything has to be confirmed with the biopsy because that is the gold standard for testing (Doctors words). You also answered another question I forgot... -
- trents replied to Skg414228's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms8
Does High DGP IGA Typically Mean Celiac?
The tests outlined in the article I linked are rated according to "sensitivity" and "specificity". Sensitivity refers to how well the test does in not missing those who actually have the disease being tested for, in this case, celiac disease. The DGP-IGA test is estimated to have a sensitivity of 75% to 95%. Specificity refers to how well the test... -
- Flosdiner replied to jadhikary's topic in Traveling with Celiac Disease10Gluten-Free House Swaps
How cold is Ottawa in winter? -
- Skg414228 replied to Skg414228's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms8
Does High DGP IGA Typically Mean Celiac?
It is interesting you mentioned that it could be other things because I asked my gastro and she literally said it means nothing else. That that value was only considered for Celiac which is kind of why I asked here because I didn't understand how a celiac only value could be high and it wasn't celiac.
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No, you don't necessarily need multiple testing methods to confirm celiac disease. There is an increasing trend for celiac diagnoses to be made on a single very high tTG-IGA test score. This started in the UK during the COVID pandemic when there was extreme stress on the healthcare system there and it is spreading to the US. A tTG-IGA score of somewhere between 5x and 10x normal is good enough by itself for some physicians to declare celiac disease. And mind you, that is the tTG-IGA, not the DGP-IGA. The tTG-IGA is the centerpiece of celiac antibody testing, the one test most commonly ordered and the one that physicians have the most confidence in. But in the US, many physicians still insist on a biopsy, even in the event of high tTG-IGA scores. Correct, the biopsy is considered "confirmation" of the blood antibody testing. But what is the need for confirmation of a testing methodology if the testing methodology is fool proof? As for the contribution of genetic testing for celiac disease, it cannot be used to diagnose celiac disease since 40% of the general population has the genetic potential to develop celiac disease while only 1% of the general population actually develops celiac disease. But it can be used to rule out celiac disease. That is, if you don't have the genes, you don't have celiac disease but you might have NCGS (Non Celiac Gluten Sensitivity).
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Okay yeah that helps! To answer your last bit my understanding was that you need to have multiple tests to confirm celiac. Blood, biopsy, dna, and then I think symptoms is another one. Either way I think everything has to be confirmed with the biopsy because that is the gold standard for testing (Doctors words). You also answered another question I forgot to ask about which is does a high value push to a higher % on those scales. I truly appreciate your answers though and just like hearing what other people think. Digging into forums and google for similar stuff has been tough. So thank you again!
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The tests outlined in the article I linked are rated according to "sensitivity" and "specificity". Sensitivity refers to how well the test does in not missing those who actually have the disease being tested for, in this case, celiac disease. The DGP-IGA test is estimated to have a sensitivity of 75% to 95%. Specificity refers to how well the test does in not producing a positive score to medical conditions other than the one being tested for, in this case, celiac disease. The DGP-IGA test is estimated to have a specificity of 90% to 100%. Obviously, in your case there is no issue with sensitivity. So, the only remaining question would be in relation to specificity. It is my observation from participating in this forum for many years and reading the posted test results from many, many forum contributors, that the likelihood of misdiagnosis due to a specificity issue diminishes greatly with high test score numbers. Still, there is a slight chance it could be due to something else. Think about it. If this were not so, why would your GI doc even be scheduling you for a biopsy?
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It is interesting you mentioned that it could be other things because I asked my gastro and she literally said it means nothing else. That that value was only considered for Celiac which is kind of why I asked here because I didn't understand how a celiac only value could be high and it wasn't celiac.
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