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- knitty kitty replied to Travel Celiac's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2Test says no, but body says Yes?
Welcome to the forum, @Travel Celiac! You have to be consuming gluten for your body to trigger the autoimmune response and produce anti-gluten antibodies. If you're not consuming gluten, the autoimmune response is not triggered and you won't produce anti-gluten antibodies. Celiac Disease is genetic. Your genes don't change. You will always have... -
- trents replied to Kipman's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms5Indeterminate transglutaminase iga
I've never heard it said that celiac disease is a connective tissue disease. It is an autoimmune disorder that (classically) attacks the lining of the small bowel but we now know it can manifest in other body systems. It is also true that autoimmune disorders tend to cluster. That is, when you have one you often develop others. -
- Kipman replied to Kipman's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms5Indeterminate transglutaminase iga
I did for a week, though that was 4 weeks before I had the test done. The doctor told me the lab rang her and said they hadn't seen results like it in their lab. Them being nearly all indeterminate that is. I also tested positive for a multiple connective tissue disease but when they did further testing it was all indeterminate too (I've only just... -
- trents replied to Kipman's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms5
Indeterminate transglutaminase iga
So, it sounds like you may have already been avoiding gluten before the blood draw was done for the antibody testing. Is this correct? -
- trents replied to Travel Celiac's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms2
Test says no, but body says Yes?
Welcome to the forum, @Travel Celiac! The high total IGA does not indicate that your celiac disease is actively flaring up. Total IGA is not a test for celiac disease per se but rather is test given to determine if you are IGA deficient, which you are not. IGA deficient people will experience artificially low individual IGA antibody tests such as the...
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By knitty kitty · Posted
Welcome to the forum, @Travel Celiac! You have to be consuming gluten for your body to trigger the autoimmune response and produce anti-gluten antibodies. If you're not consuming gluten, the autoimmune response is not triggered and you won't produce anti-gluten antibodies. Celiac Disease is genetic. Your genes don't change. You will always have the Celiac genes whether you eat gluten or not. Your negative tTg-IgA shows that you are successfully keeping gluten out of your diet. You are doing very well on that point, but you still are Celiac. Be proud of your accomplishment! -
I've never heard it said that celiac disease is a connective tissue disease. It is an autoimmune disorder that (classically) attacks the lining of the small bowel but we now know it can manifest in other body systems. It is also true that autoimmune disorders tend to cluster. That is, when you have one you often develop others.
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I did for a week, though that was 4 weeks before I had the test done. The doctor told me the lab rang her and said they hadn't seen results like it in their lab. Them being nearly all indeterminate that is. I also tested positive for a multiple connective tissue disease but when they did further testing it was all indeterminate too (I've only just realised that celuac is a connective tissue disease)
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So, it sounds like you may have already been avoiding gluten before the blood draw was done for the antibody testing. Is this correct?
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Welcome to the forum, @Travel Celiac! The high total IGA does not indicate that your celiac disease is actively flaring up. Total IGA is not a test for celiac disease per se but rather is test given to determine if you are IGA deficient, which you are not. IGA deficient people will experience artificially low individual IGA antibody tests such as the tTG-IGA and can result in false negatives. The other question is why is your total IGA count high? That can indicate other health issues besides celiac disease so I suggest you research that question and also talk to your physician about it. Here is an article that explains the various tests that can be run to detect celiac disease and the significance of the total IGA test: Having said all that, I gather that for some reason you are under the mistaken impression that, having been diagnosed with celiac disease some years ago, your recent antibody test should still show elevated levels if you actually do have celiac disease, at least when you have accidental gluten exposure. I think you misunderstand how this all works and what the testing is designed to detect. When someone has celiac disease, the consumption of gluten triggers an autoimmune response that, typically, causes inflammation in the lining of the small bowel. This inflammation produces specific antibodies that can be detected by serum testing specifically designed to look for these antibodies. Upon the onset of celiac disease, it can take weeks or months of consistent exposure to gluten for the serum antibody levels to build up to the point where they are detectable by the tests. Once gluten is removed from the diet, inflammation begins to subside and antibody levels begin to drop. An occasional gluten exposure will not result in restoring antibody levels to detectable amounts once they have receded to normal levels after going gluten free. Again, it takes weeks or months of consistent gluten ingestion for the antibody counts to reach sufficient levels to produce a positive test result. Yes, you still have celiac disease but it looks like from your recent tTG-IGA test result that you are doing a good job with the gluten free lifestyle.
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