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A Novel Serogenetic Approach Determines The Community Prevalence Of Celiac ... - 7Thspace Interactive (Press Release)

Scott Adams

By Scott Adams
in Publications & Publicity

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Scott Adams Grand Master
Scott Adams
Posted

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7thSpace Interactive (press release)

Changing perspectives on the natural history of celiac disease (celiac disease), new serology and genetic tests, and amended histological criteria for diagnosis cast doubt on past prevalence estimates for celiac disease. We set out to establish a more accurate prevalence ...

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      Can you please educate me regarding my recent test results. Ive been gluten free for years. Recent deamidated gliadin Abs, IgA result is 0.9/‘not detected’ but deamidated gliadin Abs, IgG is 26.6/abnormal high. (Normal range is <15.0) So…what can this indicate? 
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      The positive Anti-deamidated Gliadin IgA result (12 U/ml) suggests possible celiac disease, but it is not definitive on its own, as this marker can also be elevated in other conditions or even in non-coeliac gluten sensitivity (NCGS). Do you know if they also ran a tTg-Iga test? This is the definitive test for celiac disease. The absence of classical symptoms like significant bloating or pain upon gluten reintroduction, along with your history of IBS and sensitivity to legumes, complicates the picture (legumes can be cross-contaminated with wheat). While celiac disease remains a possibility, other conditions like NCGS, leaky gut, or additional food intolerances could also explain your symptoms. A biopsy would provide more conclusive evidence for celiac disease, but for that you need to be eating lots of gluten daily in the weeks leading up to the endoscopy. In the meantime, adopting a gluten-free diet and supporting gut health with supplements (e.g., probiotics, L-glutamine) may help reduce inflammation and symptoms, but it’s important to consult a healthcare professional to tailor your approach and rule out other underlying issues. This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. One test that always needs to be done is the IgA Levels/Deficiency Test (often called "Total IGA") because some people are naturally IGA deficient, and if this is the case, then certain blood tests for celiac disease might be false-negative, and other types of tests need to be done to make an accurate diagnosis. The article includes the "Mayo Clinic Protocol," which is the best overall protocol for results to be ~98% accurate.    
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