Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Test Results Help Please

veryami1

Recommended Posts

veryami1 Apprentice
veryami1
Posted

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


GottaSki Mentor
GottaSki
Posted

Hi,

 

I just returned from an appointment with my GI. She said I am negative for celiac, however, the copy of the test results I received said "supports a diagnosis of celiac." I am obviously confused. I went back to ask her why she said it was negative, and she didn't have time for me. Suffice to say, I won't be going back. But I do have these results and I'd like your opinion on how to interpret them.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU

Deamidated Giagin Peptide Antibody IgA - 9.3 EU

Anti-hunman tissue transglutaminase igA - 75.0 EU

Anti-endomysial igA IFA - positive

total serum iGA by Nephelometry, total igA - 129

 

One ellele HLA DqA1*05 of Dq2.5 detected, HLA DQB81*02 not detected.

Celiac risk haplotype not detected

 

I suspect because I do not test positive for the gene, she said I was negative for celiac? Any opinions? Would really appreciate any help!

 

For some reference, I blood test positive for a wheat allergy and I've been avoiding gluten for almost three weeks because I suspet celiac.

 

thank you!

 

Ami

 

Welcome Ami!

 

Looks like your doctor is wrong and you do have Celiac Disease in addition to your wheat allergy - Make sure your primary doc gets copies of all these tests -- unless you want to proceed with an endoscopy, there is no need for a celiac specialist.  If you decide to proceed with an endo -- try to find another GI that has training/experience with Celiac Disease.

 

Do you have the ranges for these tests -- they certainly look like they support a diagnosis of Celiac Disease - especially the positive Anti-Endomysial IgA -- also known as EMA-IgA.

 

Were you already gluten free for a time before these antibody tests were run?

 

Let us know the ranges if you have them.

veryami1 Apprentice
veryami1
Posted
  • Author

Hi Lisa,

Thanks for the quick reply. These are the ranges listed on the paperwork, in parenthesis.

 

Deamidated Gliadin Peptide Antibody - IgG - 43.0 EU  (<4.9 EU)

Deamidated Giagin Peptide Antibody IgA - 9.3 EU  (<6.1 EU)

Anti-hunman tissue transglutaminase igA - 75.0 EU (<10.3)

Anti-endomysial igA IFA - positive  (range, negative)

total serum iGA by Nephelometry, total igA - 129   (<3 years, 8-220, 3-13 years 41-395, >13, 44-441)

 

I don't know how to interpret any of the above!

 

I've been wheat/gluten free for 3 weeks, on Saturday. At the time of the above blood test, I was about 2 weeks free.

 

What leads you to quickly say that yes, I am celiac positive?

 

Thanks for any help! I found another doctor for a follow up in two weeks, will stay gluten-free regardless of all of this! My allergies seem to be clearing although my stomach issues are roughly the same since starting gluten-free.

 

Ami

cmc811 Apprentice
cmc811
Posted

Every one of your tests was positive. Get a new GI or like Lisa said make sure your PCP has these results.

GottaSki Mentor
GottaSki
Posted

Every one of these tests is strong positive, which is what it looked like - but I do like to see ranges because ranges vary between labs.

 

Glad you'll be seeing another doctor soon.

 

It takes time for symptoms to improve gluten-free.  Sometimes it is days, weeks, months and sadly even years....but things do improve.  Healing happens.

 

The tTG-IgA and EMA-IgA both indicate there is damage within your small intestine caused by an autoimmune reaction that your body has to gluten.  This is not an allergy, but a person can be both celiac and allergic to wheat, barley or rye.

 

The  Deamidated Gliadin Peptide (DGP-IgA and IgG) are tests that measure the antibodies your body is producing to one of the peptides in the protein of Gluten - called Gliadin.

 

Hope that make sense.  

 

If there is a chance that you will be having an endoscopic biopsy you will need to continue to consume gluten each day -- it can be very tough to add it back in, so talk to the new doctor about your options.

 

Here is a great thread for those newly diagnosed and those new to living gluten-free:

 

https://www.celiac.com/forums/topic/91878-newbie-info-101/

 

Hang in there :)

veryami1 Apprentice
veryami1
Posted
  • Author

Thank you all SO much! What do the allelle results mean?

 

Do you think that she interpreted the results as negative simply because I did not test positive for both genes? How can she be so stupid, to put it not so mildly?

 

With these results, is there ANY WAY I can not have celiacs, not taking into account possible testing errors or such?

 

Looking forward to getting to know everyone here more, since I think I'll be staying around :)

 

Ami

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      127,509
    • Most Online (within 30 mins)
      7,748
    Mr-Collateral531
    Newest Member
    Mr-Collateral531
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.2k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Matt13
      Certified gluten free oats

      By Matt13 · Posted

      Thanks for the reply ! I am asking because tomorow i have egd and nobody told me not to eat gluten-free oats… and i was scared that it could ruin my biopsy results… 
    • trents
      Certified gluten free oats

      By trents · Posted

      Yes, I would think that for the 10% of celiacs who can't tolerate oats it would cause villous atrophy just like gluten. No, it would not produce marsh 3b villous atrophy in a couple of days. Nothing will produce measurable villous atrophy that fast. It takes at least two weeks of at least 10g of gluten consumption daily (10g is the amount found in about 4-6 slices of wheat bread) to develop measurable villous atrophy and even then probably not 3b villous atrophy. Are you asking these questions in because you are considering taking on a gluten challenge?
    • Matt13
      Certified gluten free oats

      By Matt13 · Posted

      Thanks for the awnsers i understand there is maybe system reaction but do they create or cause villious atrophy? And igmf you it them for example a couple of days di they instantly induce marsh 3b?
    • robingfellow
      Can gallbladder issues cause symptoms of celiac disease?

      By robingfellow · Posted

      My gallbladder was at 94% ejection fraction according to my HIDA scan before surgery, when the "normal" range is considered to be between 30-80%, so the surgeon recommended removal because I had been experiencing severe chronic upper quadrant pain and even vomiting despite having a strong stomach. A biopsy after surgery showed intense inflammation suggesting my gallbladder was on the verge of bursting if I hadn't gotten it removed.   The last time my iron and vitamin d levels were checked post-gluten free diet they were in a normal range (I take 60mg iron tablets every other day, and vitamin D capsules daily) I do also take magnesium daily, specifically 400mg magnesium bisglycinate at night to aid my sleep since I try to avoid taking melatonin due to personal preference.   I'll definitely have to keep in mind the point about celiac possibly causing gallbladder problems, I'll probably wait until I can see a proper GI and get their input before I attempt to reintroduce gluten back into my diet that way any reaction I may or may not have can be properly assessed.
    • Mr-Collateral531
      Can gallbladder issues cause symptoms of celiac disease?

      By Mr-Collateral531 · Posted

      I have dealt with gallbladder issues on-and-off for about ten years now. I was diagnosed with biliary dyskinesia in 2016 but chose to keep my gallbladder. Then in July 2022, I was diagnosed with celiac disease. Your surgeon is partially right in that your gallbladder can definitely cause some of those issues. However, the flip side to the coin is celiac can cause issues with your gallbladder. It’s a lesser studied area of disease manifestation, but limited research has shown a correlation between celiac, gallbladder dismotility, and how a gluten-free diet can help increase the gallbladder ejection fraction. Which literally happened in my case. In 2016 my HIDA scan measured my gallbladder ejection fraction as 29%. Then in 2023 after going strict gluten free, my HIDA scan measured it as 100%. It’s not perfect. I get right upper quadrant pain from time to time still. But at least I got that piece of evidence for myself.  I haven’t found any empirical studies on it but I have a theory. The gallbladder stores your bile for digestion. When the food enters your small intestine, the cells of your duodenum secrete cholecystokinin (CCK). CCK is what tells your gallbladder to empty. It’s literally Greek for “bile sac move.” Since the duodenum is a prime location for epithelial cell damage in celiac, it seems very possible that this can alter production of digestive hormones like CCK. As the small intestine begins to heal it produces more CCK and therefore the gallbladder can once again function. If you care to share, why did you need to have yours removed? In regards to the low iron and low vitamin D despite supplementation, that is also common in celiac. I fought vitamin D deficiency for almost a year despite taking 5000 IUs a day. I don’t have anemia, but I know I can use more iron based on my last round of blood work. Best I can say is you need to right cofactors as well. My vitamin D level virtually stayed the same for three different blood tests all 12 weeks apart. One was even after taking the prescription vitamin D of 50,000 IUs once a week. Once again, something not all doctors seem to know, but a nutrient deficiency isn’t necessarily treated by just taking more of that nutrient. Vitamin D metabolism requires many cofactors and processes in the small intestine, liver, and kidneys. And iron metabolism requires many cofactors as well including vitamin D. The biggest thing is to find a supplement regiment that works for you. Do you take specific vitamins or do you take a multivitamin? How much iron is in the supplement you take? What type of iron is it? Do you take magnesium? Another big game changer for me was adding 450mg/day of magnesium supplements for about two months and then dropping to 200mg/day. I would take 250mg of magnesium aspartate at lunch time and then 200mg of magnesium glycinate around 7:00pm. Magnesium is a huge cofactor for both vit D and iron metabolism. And that’s just one. Zinc, copper, vitamin K, boron, vitamin B6, folate, vitamin B12, and vitamin C are all contributing cofactors to vitamin D and iron metabolism. But too much supplementing is also dangerous. I’ve also been through iron overload and zinc toxicity in my post-celiac journey. Once again, doctors just saying to do one thing without considering anything else. I hope this helps and if you have any more questions don’t hesitate to ask.          
×
×
  • Create New...