Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

False Positive Vs False Negative. What's More Reliable?


woodyfly

Recommended Posts

woodyfly Rookie

Did a skin allergy test about half a year ago. Tested to be maximum allergic to wheat, medium-mild allergy to chicken, eggs, beer. Wasn't convinced because I've been eating those foods since as long as I can remember and although I do have -some- symptoms that can be tied to an allergy (stuff nose, gas, adult acne, eczema). I did another skin test today at another location and all those allergies were NEGATIVE this time. 

 

So... what's more probable? That the first time resulted in a bunch of false positives or this time they were false negatives?


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



kareng Grand Master

Did a skin allergy test about half a year ago. Tested to be maximum allergic to wheat, medium-mild allergy to chicken, eggs, beer. Wasn't convinced because I've been eating those foods since as long as I can remember and although I do have -some- symptoms that can be tied to an allergy (stuff nose, gas, adult acne, eczema). I did another skin test today at another location and all those allergies were NEGATIVE this time. 

 

So... what's more probable? That the first time resulted in a bunch of false positives or this time they were false negatives?

I moved this to " Other food intolerances" because you are talking about allergy testing, not Celiac testing.

I don't know a lot about allergy testing, but I have heard it is very hard to test for food allergies.

StephanieL Enthusiast

A positive result is 50/50 on accuracy.

 

A negative result is about 90% accurate.

 

it is not recommended that you have allergy testing unless there has been a KNOW reaction because of the unreliable nature of these tests.

 

(This is for IgE mediated allergies via blood or skin testing- NOT alternative testing which has no science to back it up.)

cyclinglady Grand Master

Have you considered getting tested for celiac disease? Celiac disease is not an allergy to wheat. It is an autoimmune response to gluten. There is special celiac blood test.

In my experience I had no intestinal issues, just anemia at the time of my diagnosis and I was consuming lots of wheat daily!

nvsmom Community Regular

Celiac testing is different than allergy testing: false negatives are more common that false positives.  With celiac disease blood testing, the specificity is usually around 95%, which means only 5% of people get a positive result that was not caused by celiac disease, whereas the sensitivity can range between (approximately) 20 to 95%, meaning these tests can miss from 1/20 to 4/5 celiacs.

 

This report (page 12) discusses the celiac disease tests and their reliability: Open Original Shared Link

 

If you get tested for celiac disease, you must be eating gluten in the 8-12 weeks prior to testing or a celiac has a large chance of getting a false negative result.  If you are avoiding wheat and barley (beer) due to an allergy, you'll have to focus on rye, durum, semolina, spelt, kamut or graham flours

 

Best wishes.

kareng Grand Master

Celiac testing is different than allergy testing: false negatives are more common that false positives. With celiac disease blood testing, the specificity is usually around 95%, which means only 5% of people get a positive result that was not caused by celiac disease, whereas the sensitivity can range between (approximately) 20 to 95%, meaning these tests can miss from 1/20 to 4/5 celiacs.

This report (page 12) discusses the celiac disease tests and their reliability: Open Original Shared Link

If you get tested for celiac disease, you must be eating gluten in the 8-12 weeks prior to testing or a celiac has a large chance of getting a false negative result. If you are avoiding wheat and barley (beer) due to an allergy, you'll have to focus on rye, durum, semolina, spelt, kamut or graham flours

Best wishes.

Actually, durum, semolina, spelt, kaput and graham are actually wheat. They are just a slightly different version of wheat. Like a Granny Smith is a bit different version of an apple from a Red Delicious.
nvsmom Community Regular

Good point!


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      127,739
    • Most Online (within 30 mins)
      7,748

    Klsdurbin
    Newest Member
    Klsdurbin
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.4k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Scott Adams
      That’s an interesting observation! The timing you mention does raise questions about the relationship between modern wheat varieties and the emergence of Non-Celiac Gluten Sensitivity (NCGS). Norman Borlaug’s work on high-yield, disease-resistant wheat during the Green Revolution significantly increased global food production, but it also led to changes in the composition of wheat, including higher gluten content to improve baking qualities. While NCGS was formally recognized as a condition in the 2010s (https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-10-13 and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820047/) , it’s important to note that the awareness and diagnosis of gluten-related disorders have evolved over time. Some researchers suggest that modern wheat breeding practices, along with changes in food processing and gut health, may contribute to the rise in gluten sensitivity. However, the exact mechanisms behind NCGS are still not fully understood, and it remains a debated topic in the scientific community. It’s also worth considering that increased awareness and improved diagnostic tools have played a role in identifying conditions like NCGS that may have existed but were previously unrecognized. The interplay between genetic, environmental, and dietary factors makes this a complex issue, and more research is needed to fully understand the connections.
    • Scott Adams
      Here is a recent reply to a Celiac.com email asking for comment about gluten contamination detected in their bakery products: You can read more about it in this thread:  
    • trents
      @Marie70, it is very important that your daughter not begin experimenting with eating gluten free until all testing for celiac disease is complete. Doing so will invalidate the testing. Normally, the testing involves two stages. The first stage is blood antibody testing as per the article linked by Scott above. As you can see from the article, there are a number of tests that can be ordered when diagnosing celiac disease but most physicians will not order a complete panel. At the very minimum, your daughter should request two antibody tests, "total IGA" and "tTG-IGA". The tTG-IGA is considered the centerpiece of celiac disease testing but if total IGA is low (i.e., if she is IGA deficient), this will result in an artificially low tTG-IGA score and possibly a false negative. Many general practitioners are not very knowledgeable about celiac disease testing so we have found we have to be a little assertive in order to get proper testing done. I don't know under the relational circumstances how much input you will have with your daughter about these things but I thought I'd pass the info on to you anyway. The second stage of celiac disease testing involves an endoscopy with biopsy of the small bowel lining which is then sent to a lab for microscopic analysis. This checks for damage to the small bowel lining and is confirmation if any of the blood antibody tests are positive. It is also considered to be the gold standard of celiac disease diagnosis. Again, should her antibody testing be positive, your daughter would still need to be consuming gluten until after the endoscopy/biopsy is complete.
    • Klsdurbin
      No!!! Celiacs disease does not go away. You can’t outgrow it, and if all proper diagnostic procedures (blood test and endoscopy) were followed when you were 8, it’s almost impossible to be mis-diagnosed.    stoms and reactions to gluten do change over time, but the fact you have celiacs does not.    I think that a lot of people misunderstand that the goal to managing your celiacs is to eventually test negative for celiacs. This does not mean it went away, it means that your gluten-free diet is working and you’re no longer producing the anti-bodies that will wreak havoc on your health.    if you can access the medical records from when you were 8 and have a GI doctor review them, I would highly recommend you do this. 
    • Klsdurbin
      Inovera offers a supplement called Forvia that they claim is formulated for better absorption for those with GI issues including Celiacs Disease.    I would love to hear if anyone has tried it and thinks it might be good. 
×
×
  • Create New...