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Positive ANA, Low IGA and IGM, What does everything mean as a whole?

meowmix
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meowmix Newbie
meowmix
Posted

Iron: 17 mcg/dL (Low) November 11, 2016

Ferritin: 1.8 ng/mL (Low) November 11, 2016

RBC: 4.05x10^6/uL (Low) November 11, 2016

Hemoglobin: 8.5 gm/dL (Low) November 11, 2016

Vitamin D: 25.7 ng/mL (Low) February 22, 2017

ANA Profile :  February 27, 2017

FANA:  Positive

 FANA Titer: 1:640

FANA Pattern: Homogenous

Gliadin IgA: 2 units June 29, 2017

Gliadin IgG: 3 units June 29,2017

TTG Ab IgA: <1 units/mL June 29, 2017

TTG Ab IgG: <1 units/mL June 29, 2017

Immunoglobulin A:  59.1 mg/Dl (Low) July 10, 2017

Immunoglobulin M: 44.2 mg/Dl (Low) July 10,2017

Immunoglobulin G: 1010.0 mg/Dl (Normal?) July 10, 2017

Immunoglobulin E: 5 KU/L July 10,2017

My RBC and Hemoglobin have come up and are normal.  My iron levels will get high (too high) when I take 65 mg elemental iron twice a day for several weeks but my ferritin has never gotten over 42 ng/mL.  When I stop taking my iron supplement my iron and ferritin plummet in just a matter of weeks.  My hair is falling out, I get rapid heartbeat when I get too low on iron and if I get my iron too high.  My whole body hurts especially my finger joints, back , knees and really all of my joints.  Going to the bathroom at least 2 times day and sometimes up to 5 times a day.   Extreme fatigue, Brain fog, extremely emotional and irritable.  I just went gluten free July 1, 2017 and am starting to feel better.  Joints feel better, I can sleep better, my mood is better.  Celiac or maybe just gluten sensitive?  Any thoughts?  What do my labs say about me?        

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cyclinglady Grand Master
cyclinglady
Posted
5 hours ago, meowmix said:

Iron: 17 mcg/dL (Low) November 11, 2016

Ferritin: 1.8 ng/mL (Low) November 11, 2016

RBC: 4.05x10^6/uL (Low) November 11, 2016

Hemoglobin: 8.5 gm/dL (Low) November 11, 2016

Vitamin D: 25.7 ng/mL (Low) February 22, 2017

ANA Profile :  February 27, 2017

FANA:  Positive

 FANA Titer: 1:640

FANA Pattern: Homogenous

Gliadin IgA: 2 units June 29, 2017

Gliadin IgG: 3 units June 29,2017

TTG Ab IgA: <1 units/mL June 29, 2017

TTG Ab IgG: <1 units/mL June 29, 2017

Immunoglobulin A:  59.1 mg/Dl (Low) July 10, 2017

Immunoglobulin M: 44.2 mg/Dl (Low) July 10,2017

Immunoglobulin G: 1010.0 mg/Dl (Normal?) July 10, 2017

Immunoglobulin E: 5 KU/L July 10,2017

My RBC and Hemoglobin have come up and are normal.  My iron levels will get high (too high) when I take 65 mg elemental iron twice a day for several weeks but my ferritin has never gotten over 42 ng/mL.  When I stop taking my iron supplement my iron and ferritin plummet in just a matter of weeks.  My hair is falling out, I get rapid heartbeat when I get too low on iron and if I get my iron too high.  My whole body hurts especially my finger joints, back , knees and really all of my joints.  Going to the bathroom at least 2 times day and sometimes up to 5 times a day.   Extreme fatigue, Brain fog, extremely emotional and irritable.  I just went gluten free July 1, 2017 and am starting to feel better.  Joints feel better, I can sleep better, my mood is better.  Celiac or maybe just gluten sensitive?  Any thoughts?  What do my labs say about me?        

What does your doctor say or advise?   I am glad that you are feeling better, we are not doctors and we can not diagnose you.  We can offer you supoort and we sure know a lot about the gluten free diet.   We can definitely help you with that!  

meowmix Newbie
meowmix
Posted
  • Author

I haven't heard back from my doctor yet.  I was just wondering if any of my these labs where common among people with celiac.  Thanks for responding!

cyclinglady Grand Master
cyclinglady
Posted

It seems like you have a lot going on, so it would be best to talk to your doctor.  Lab ranges are missing, so I could not say if your celiac panel is positive or not.  Each lab varies.  Would hate to point you in the wrong direction.  

I can tell you that anemia  was my main symptom.  Doctors all my life blamed menstruation for my iron deficiency and I already had a genetic anemia.  So, I was dismissed.  Find out the real reason as to why you continue to be anemic.   

meowmix Newbie
meowmix
Posted
  • Author

Thanks for responding again.  None of the nurse practitioners or the doctor would ever really say what caused my anemia.  They all kinda thought that it was from heavy periods.  Gosh, you go in to see a doctor or nurse practitioner and they have about 10 minutes to give you before they start backing out the door.  Its kinda no wonder why no one ever gets the whole story or finds out whats really wrong (or why it takes so long to finally figure it out).  It sucks for the patient but it also sucks for the nurses and doctors because they are stretched so thin.  I know what it is like to work when there is too much to do and not enough time or people to do it.  It hurts everyone.  

Hatbox121 Apprentice
Hatbox121
Posted

Have you not been sent to rheumatology to further investigate the positive ANA? A positive ANA alone can't diagnose anything but it does warrant further investigation and more blood work, ie lupus, RA, scleroderma, etc depending on symptomology. 

There is also an anemia of chronic disease which I think can be connected to certain connective tissue disorders.

meowmix Newbie
meowmix
Posted
  • Author

My RA blood test was negative and my dsDNA was negative too.  I think that the dsDNA is the lupus test.  I think.  I haven't been referred to a rheumatologist.   

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Hatbox121 Apprentice
Hatbox121
Posted
16 hours ago, meowmix said:

My RA blood test was negative and my dsDNA was negative too.  I think that the dsDNA is the lupus test.  I think.  I haven't been referred to a rheumatologist.   

No anti-sm(lupus)? Yes, anti dsDNA is for SLE(lupus). No ENA panel,anti-RNP, anti-SS-A, anti-SS-B, anti histone, scl-70, etc? I'd ask for a referral, if you feel that there is something going on. I think that would be a logical step because of the positive ANA and lack of investigation. 1:640 is definitely positive. 

meowmix Newbie
meowmix
Posted
  • Author

SSB <3.3 RLU <=20 (reference range)

RNP <3.5 RLU <=20

Sm <3.3 RLU <=20

SSA Ro52 <2.3 RLU <=20

SSA Ro60 <4.9 RLU <=20

Scl 70 <1.2 RLU <=20

Jo 1 <2.2 RLU <=20

ds DNA Negative

FANA Positive

FANA Titer 1:640

FANA Pattern Homogeneous

 

 

  • 2 years later...
caulodren Newbie
caulodren
Posted

ana+ positive can be positive with seasonal allergies as well, i had a similar problem

pikakegirl Enthusiast
pikakegirl
Posted

I always have a high positive ANA. Diagnosed 13 years ago. Militant gluten free, I don't eat out at all. My thyroid causes many of the symptoms you describe if it is out of my comfort range, which is individual on a large scale of normal. The normal range is to wide and I feel that is why many are not properly diagnosed. My perfect number is 1.5 but I am best going closer to hyper than to hypo. Have you been checked for Hashimotos?

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    • trents
      Family education

      By trents · Posted

      Rogol72, your recommendation to the OP to "show them pictures of dermatitis herpetiformis" confuses me as the OP does not mention having dermatitis herpetiformis.
    • Rogol72
      Family education

      By Rogol72 · Posted

      Hi @sillyyak52, I empathize with you. I would suggest showing them pictures of "dermatitis herpetiformis" which is a complication of undiagnosed/untreated Coeliac Disease. You can find them on Google images. It's pretty alarming to see and it may be the wake up call they need to visually understand what gluten can really do to the body. In this case the skin ... The Coeliac rash that won't go away without a strict gluten free diet and Dapsone treatment (a toxic antibiotic). I'd also look at @glutenhatesmyguts on youtube  ... a funny educational take on Coeliac Disease ... the clips titled as follows may help ... "Celiac Disease Explained | Why Gluten REALLY Hates My Guts!" and "Story time: I almost ..." This person is on Tiktok also and has a category "Coeliac & gluten-free Info ". There's plenty of Coeliacs on Tiktok and IG posting frequently and advocating for themselves about the need to be strict and what happens when they get glutened.    Celiac Canada also has good resources on YT, both long and short educational clips  ... @CCACeliac . Do you know any Coeliacs in your area who could help you explain the need to be so strict? Some Coeliacs have mild symptoms while others have awful reactions to just a few crumbs. Or maybe the nurse could put you in contact with some other Coeliacs or a support group to help you with your family. Hope this helps you. And keep advocating for yourself no matter what.
    • AndiOgris
      False blood test positive?

      By AndiOgris · Posted

      Hi Trents, Thanks for your response! And yes, the TTG-IGA was the only test done. We did some more general blood tests at the time of the initial celiac test in 2023, but none showed any deficiencies usually associated with celiac disease.  I'll mention the new gluten challenge guidelines to my doctor, perhaps he will ask me to do the test again? And I'll see what he says more generally... Thanks again!
    • captaincrab55
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      By captaincrab55 · Posted

      Welcome sillyyak52,  I'm not sure of your age or if you live with your parents.  Is there a nurse in your family or friend of the family that may be able to explain your diagnoses?  You can get a second opinion by taking your lab results to another GI Doctor.   Good Luck!
    • trents
      Dangerously underweight, Perfect gluten free and insomnia

      By trents · Posted

      So, you have three symptoms of a gluten-related disorder: weight loss, brain fog and lose stools. Of the three, the lose stools that firm up when you cut back on gluten is the only symptom for which you have reasonable cause to assume is connected to gluten consumption since the other two persist when you cut back on gluten. But since you do not have any formal test results that prove celiac disease, you could just as easily have NCGS (Non Celiac Gluten Sensitivity). In fact, what testing you have had done indicates you do not have celiac disease. NCGS shares many of the same symptoms of celiac disease but does not damage the lining of the small bowel as does celiac disease. There is no test for it. A diagnosis for NCGS depends on first ruling out celiac disease. It is 10x more common than celiac disease. Some experts feel it can be a precursor to the development of celiac disease. Eliminating gluten is the antidote for both. What muddies this whole question are two things: 1. Lack of official diagnostic data that indicates celiac disease. 2. Your persistence in consuming gluten, even though in smaller amounts. Your anxiety over the insomnia seems to outweigh your anxiety over the weight loss which prevents you from truly testing out the gluten free diet. What other medical testing have you had done recently? I think something else is going on besides a gluten disorder. Have you had a recent CBC (Complete Blood Count) and a recent CMP (Complete Metabolic Panel)? You say you don't believe you have any vitamin and mineral deficiencies but have you actually been tested for any. I certainly would be concerned with that if I was losing weight like you are despite consuming the high amount of calories you are.
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