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News: Celiac.com: PvP Biologics Creates First Therapeutic Enzyme for Celiac Disease


Scott Adams

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Scott Adams Grand Master

Around 1 percent of the American population is affected by celiac disease. For the ... Most are slow or don't target all of the gluten molecules. ... “The obvious [benefit is that] you don't have to worry about following a gluten-free diet.

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Ennis-TX Grand Master

Good in theory but I have a feeling they will flop like all of the other enzyme therapies.....like trying to prevent the sticky floor and mess of pouring a glass of juice on the floor by putting down a pile of paper towels...you going to get most of it but some is going to get through some is going to splatter and cause collateral issues......you can not just intercept and try to prevent a reaction to a bloody molecule smaller then a germ, a dang protein, buy trying to eliminate it after it has entered the body......like drinking bleach/antifreeze and trying to puke it all back up....it is in your body your going to get some ill effect maybe not as bad or quick.  

Key is eliminating the gluten before it enters the body, or turning off the bodies response to the protein. THOSE would be what we need, I see more potential in a kind of "gluten vaccine" that might turn off our immune response to gluten. Even is just a temporary measure like say a crispr RNA treatment or a targeted immune suppressant.

I think these doctors might have to experience how even the tiniest CC effects many of us and how before they try coming up with a half baked treatment of dealing with it in the body.

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    • par18
      Thanks for the reply. 
    • Scott Adams
      What you’re describing is actually very common, and unfortunately the timing of the biopsy likely explains the confusion. Yes, it is absolutely possible for the small intestine to heal enough in three months on a strict gluten-free diet to produce a normal or near-normal biopsy, especially when damage was mild to begin with. In contrast, celiac antibodies can stay elevated for many months or even years after gluten removal, so persistently high antibody levels alongside the celiac genes and clear nutrient deficiencies strongly point to celiac disease, even if you don’t feel symptoms. Many people with celiac are asymptomatic but still develop iron and vitamin deficiencies and silent intestinal damage. The lack of immediate symptoms makes it harder emotionally, but it doesn’t mean gluten isn’t harming you. Most specialists would consider this a case of celiac disease with a false-negative biopsy due to early healing rather than “something else,” and staying consistently gluten-free is what protects you long-term—even when your body doesn’t protest right away.
    • Scott Adams
      Yes, I meant if you had celiac disease but went gluten-free before screening, your results would end up false-negative. As @trents mentioned, this can also happen when a total IGA test isn't done.
    • Seaperky
      I found at Disney springs and Disney they have specialist that when told about dietary restrictions they come and talk to you ,explain cross contamination measures tsken and work with you on choices. Its the one place I dont worry once I've explained I have celiac disease.  Thier gluten free options are awesome.
    • Churley
      Have you tried Pure Encapsulations supplements? This is a brand my doctor recommends for me. I have no issues with this brand.
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