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Help me!! interpret my blood panel results

Lgerb6

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Lgerb6 Rookie
Lgerb6
Posted

The Dr said via phone that it is likely I have celiac. I received more numbers today. Do these show a definitive positive? I think they are awaiting one more celiac result. I do see a GI in a couple weeks. See below:

Gliadin igA 63.9 with standard range <15

Gliadin igG 177.4 with standard range <15

Tissue Transglutaminase iga 208.3 with standard range <15

Tissue Transglutaminase igg 40.0 with standard range <15

Immuniglobin A 125 with reference range 70-100

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kareng Grand Master
kareng
Posted
1 hour ago, Lgerb6 said:

The Dr said via phone that it is likely I have celiac. I received more numbers today. Do these show a definitive positive? I think they are awaiting one more celiac result. I do see a GI in a couple weeks. See below:

Gliadin igA 63.9 with standard range <15

Gliadin igG 177.4 with standard range <15

Tissue Transglutaminase iga 208.3 with standard range <15

Tissue Transglutaminase igg 40.0 with standard range <15

Immuniglobin A 125 with reference range 70-100

I don't think it could be anything else with numbers that high!

cyclinglady Grand Master
cyclinglady
Posted

Your doctor is wise.  I bet your doctor said “likely”, because he wants the GI to confirm!  So, keep eating gluten until you discuss with your GI.  In the meantime, learn about celiac disease and treatment.  

Lgerb6 Rookie
Lgerb6
Posted
  • Author

Thank you!!!

squirmingitch Veteran
squirmingitch
Posted

That's about the most definitive positive across the board that I've ever seen. You're way positive on every one. Keep eating gluten every single day until the endoscopy! You don't have to eat a ton, 1 or 2 slices of gluten bread per day will do it. Orrrrrrrrrrr you could take this time to pig out on all of your favorite gluten foods to say goodbye to them. 

Ultimately, those foods will become a distant memory. There are gluten free replacements for literally everything but for 6 months to a year, you will need to eat whole foods & none of the processed stuff so you can heal.

Lgerb6 Rookie
Lgerb6
Posted
  • Author

My allergist did suggest I cut out gluten right away, but I’ll call the GI tomorrow and discuss that. Thank you!

Gemini Experienced
Gemini
Posted

My panel was the same as yours........all tests positive by large numbers so you can consider yourself a Celiac.  Are you very symptomatic?

I will add that I did not eat Whole Foods exclusively when healing.  I needed to gain weight badly so ate gluten-free bread and a few other things that seemed to agree with me.  Never had a problem once I went gluten free, except to discover that I had a problem with dairy also. But I healed well and all is good.  You'll be fine now that you know what the problem is.  Good luck!  :)

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squirmingitch Veteran
squirmingitch
Posted
43 minutes ago, Lgerb6 said:

My allergist did suggest I cut out gluten right away, but I’ll call the GI tomorrow and discuss that. Thank you!

From the Chicago Celiac Disease Center which is one of the premier celiac disease research & treatment centers in the world:

Are you scheduled for a biopsy? Are

you eating gluten?

Any changes in your diet can affect the accuracy of your biopsy results. It is necessary for you to be eating gluten every day for at least 4-8 weeks before the procedure. If you are scheduled for a biopsy and are not eating gluten, talk to your doctor about what is necessary to obtain accurate results. If you have
a biopsy and have eaten gluten only a short time before the test, you and your physician will not know if a negative test result is accurate or due to your diet.

Here's a link:

Open Original Shared Link

Also, you might want to read this:

Open Original Shared Link

 

Lgerb6 Rookie
Lgerb6
Posted
  • Author

Very helpful. Thank you!

Lgerb6 Rookie
Lgerb6
Posted
  • Author
11 hours ago, Gemini said:

My panel was the same as yours........all tests positive by large numbers so you can consider yourself a Celiac.  Are you very symptomatic?

I will add that I did not eat Whole Foods exclusively when healing.  I needed to gain weight badly so ate gluten-free bread and a few other things that seemed to agree with me.  Never had a problem once I went gluten free, except to discover that I had a problem with dairy also. But I healed well and all is good.  You'll be fine now that you know what the problem is.  Good luck!  :)

I am symptomatic, yes. Pretty much everything except weight loss!

Agquick Newbie
Agquick
Posted

Can I just ask what Is the difference between tt igg and tt Iga? 

squirmingitch Veteran
squirmingitch
Posted

An autoimmune disease can occur when the body's immune system mistakenly perceives a nonthreatening substance. In the case of people with celiac disease, gluten (a protein found in wheat, barley, rye, and oats) is seen as a foreign invader and is attacked by the immune system. This immune system response in celiac disease also involves the production of antibodies directed against an enzyme normally present in the intestines called tissue transglutaminase (tTG).

In celiac disease, the body produces two types of antibodies that attack tTG: immunoglobulin A (IgA) and immunoglobulin G (IgG). Measuring the IgA form of tTG antibody in the blood is more useful in detecting celiac disease because it's made in the small intestine, where gluten causes inflammation and irritation in sensitive people.

Levels of the IgG form of tTG antibody, on the other hand, are less specific to celiac disease, but may still be useful in diagnosing the condition in people who are unable to make normal amounts of IgA antibodies.

From: 

Open Original Shared Link

Agquick Newbie
Agquick
Posted

Ah ok thank you! Only because my ttg came back at 41 and am now waiting to see a doctor, not shure what all the numbers mean! 

squirmingitch Veteran
squirmingitch
Posted

It only takes on positive on the celiac serum panel to move to an endoscopic biopsy. A positive is a positive, even if it's 1/2 point above the normal range. Do not dwell on your 41 number. You have so many highs that are shockingly high that barring wearing a white coat & having a medical degree hanging on the wall; we would say you have celiac.

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      - trents replied to shell504's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
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      Should I get a second opinion?

      I would ask the GI doc about the elevated IGA score of 401. That one is what we commonly refer to as "total IGA" and also known as "Immunoglobulin A (IgA)". It could be nothing but it can also indicate some other health issues, some of them serious in nature. I would google potential causes for that if I were you. Also, if there is a chance the GI doc...
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    • trents
      Should I get a second opinion?

      By trents · Posted

      I would ask the GI doc about the elevated IGA score of 401. That one is what we commonly refer to as "total IGA" and also known as "Immunoglobulin A (IgA)". It could be nothing but it can also indicate some other health issues, some of them serious in nature. I would google potential causes for that if I were you. Also, if there is a chance the GI doc will want to do more testing for celiac disease, either antibody testing or an endoscopy with biopsy, you should not cut back on gluten consumption until all celiac disease testing is done. Otherwise, you will invalidate the testing.
    • shell504
      Should I get a second opinion?

      By shell504 · Posted

      Hello. I apologize. I didn't know there wasn't a standard.  The standard listed  for the IGA is normal range 47-310.  The others were all listed as <15.0 u/l is antibody not detected and 15> antibody is detected.  And the negative one the standard is negative.  It is a normal PCP dr. I do have a second opinion appt scheduled with a GI specialist in 2 weeks. Honestly, I haven't cut out gluten at all. I just switched to whole fibers and everything has been getting better. She wanted to do the test just to check, which I was fine with. We'll see what the GI dr says. Thank you for commenting. 
    • trents
      Mistakenly eating gluten

      By trents · Posted

      It is also possible that since eating the fries you have been glutened again during the week. I would double check the food in your cupboard and reread the ingredient lists. Food companies can and do change their formulations from time to time such that something that used to be gluten free is no more. What I am saying is, don't assume the distress you are experiencing comes from one incident of glutening. There could, coincidentally, be another one on it's heels. 
    • trents
      Should I get a second opinion?

      By trents · Posted

      Welcome to the forum, @shell504! The IGA 401mg/dl is not a test for celiac disease per se but a check to see if you are IGA deficient. People who are IGA deficient will produce celiac blood test antibody scores that are artificially low which can result in false negatives for the individual antibody tests such as the TTG IGA. You did not include reference ranges along with the test scores and since each laboratory uses custom reference range scales, we cannot comment with certainty, but from the sheer magnitude of the IGA score (401) it does not look like you are IGA deficient. And since there are no annotations indicating that the other test scores are out of range, it does not appear there is any antibody evidence that you have celiac disease. So, I think you are warranted in questioning your physician's dx of celiac disease. And it is also true that a colonoscopy cannot be used to dx celiac disease. The endoscopy with biopsy of the small bowel is the appropriate procedure for diagnosing celiac disease. But unless there is a positive in the antibody testing, there is usually no justification for doing the endoscopy/biopsy. Is this physician a PCP or a GI doc? I think I would ask for a second opinion. It seems as though this physician is not very knowledgeable about celiac disease diagnositcs. Having said all that, it may be that you suffer from NCGS (Non Celiac Gluten Sensitivity) rather than celiac disease. The two gluten disorders share many of the same GI symptoms. The difference is that NCGS does not damage the villous lining of the small bowel as does celiac disease. NCGS is 10x more common than celiac disease. The antidote for both is complete abstinence from gluten. Some experts believe NCGS can be a precursor to the development of celiac disease. There is not test for NCGS. Celiac disease must first be ruled out. So, if it becomes apparent that gluten is causing distress and testing rules out celiac disease, then the diagnosis would be NCGS. Hope this helps. 
    • shell504
      Should I get a second opinion?

      By shell504 · Posted

      I apologize i can't figure out how to get the picture on here.  Results were: IGA 401mg/dl Deamidated Gliadin IGG. <1.0 Deamidated Gliadin IGA. <1.0 Tissue Transglutaminase IGA AB. <1.0 Endomysial IGA. Negative.  Is she just going based off of the IGA alone? And because that is elevated, it's positive? The test states: "Results do not support a diagnosis of celiac disease." 
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