Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Help Interpreting Celiac HLA Genotyping Results

meg-c

Recommended Posts

meg-c Explorer
meg-c
Posted

Sorry to post another question, but I'm having difficulty interpreting my results and would appreciate feedback.

Hi! I have been having a lot of symptoms that point towards Celiac disease (can include them if that's important). My antibodies (tTG and IgA) were both normal. Apparently they can be falsely negative, so my doctor ran the HLA genotyping. Also worth mentioning that I have family history of T1DM (dad) and Graves' disease (mom), along with other familial autoimmune diseases, so I know I'm at an increased risk of developing Celiac disease.

I got a call from the nurse at the doctor's office today. My results were:

  • HLA - DQA1*05: POSITIVE
  • HLA - DQB1*02: NEGATIVE
  • HLA - DQ8: NEGATIVE

From my understanding, this is not uncommon, but doesn't totally rule celiac disease in or out. My doctor scheduled for me to have an endoscopy/colonoscopy in the new year. Some of my research (wikipedia... whoops) says that HLA - DQA1*05 is the most common positive gene in celiac.

Any further information would be greatly appreciated, thank you!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


cyclinglady Grand Master
cyclinglady
Posted
9 hours ago, meg-c said:

Sorry to post another question, but I'm having difficulty interpreting my results and would appreciate feedback.

Hi! I have been having a lot of symptoms that point towards Celiac disease (can include them if that's important). My antibodies (tTG and IgA) were both normal. Apparently they can be falsely negative, so my doctor ran the HLA genotyping. Also worth mentioning that I have family history of T1DM (dad) and Graves' disease (mom), along with other familial autoimmune diseases, so I know I'm at an increased risk of developing Celiac disease.

I got a call from the nurse at the doctor's office today. My results were:

  • HLA - DQA1*05: POSITIVE
  • HLA - DQB1*02: NEGATIVE
  • HLA - DQ8: NEGATIVE

From my understanding, this is not uncommon, but doesn't totally rule celiac disease in or out. My doctor scheduled for me to have an endoscopy/colonoscopy in the new year. Some of my research (wikipedia... whoops) says that HLA - DQA1*05 is the most common positive gene in celiac.

Any further information would be greatly appreciated, thank you!

Hi!  

To firmly rule out celiac disease (before doing the endoscopy), consider getting the rest of the celiac panel which includes the DGP and EMA.  Why?  Had my GI ordered just the TTG, my diagnosis would have been missed.  I only test positive on the DGP IgA (even in follow-up testing).  

Having celiac genes just means you are one of about 35% of the population who might develop celiac disease (only a few actually do).  This test primarily helps to rule out celiac disease for the most part and not diagnose it.  

Symptoms?  There are over 200 attributed to celiac disease and most overlap with other illnesses.  It is one reason testing is necessary for a firm diagnosis.  

Your endoscopy and colonoscopy can be very helpful if you are indeed seronegative.  Not saying you have Crohn’s, but I could have sworn that my niece had celiac disease.  A pill camera revealed Crohn’s beyond the reach of both scopes.  So, keep advocating for your health.  

meg-c Explorer
meg-c
Posted
  • Author
On 12/21/2017 at 10:21 PM, cyclinglady said:

Hi!  

To firmly rule out celiac disease (before doing the endoscopy), consider getting the rest of the celiac panel which includes the DGP and EMA.  Why?  Had my GI ordered just the TTG, my diagnosis would have been missed.  I only test positive on the DGP IgA (even in follow-up testing).  

Having celiac genes just means you are one of about 35% of the population who might develop celiac disease (only a few actually do).  This test primarily helps to rule out celiac disease for the most part and not diagnose it.  

Symptoms?  There are over 200 attributed to celiac disease and most overlap with other illnesses.  It is one reason testing is necessary for a firm diagnosis.  

Your endoscopy and colonoscopy can be very helpful if you are indeed seronegative.  Not saying you have Crohn’s, but I could have sworn that my niece had celiac disease.  A pill camera revealed Crohn’s beyond the reach of both scopes.  So, keep advocating for your health.  

Sorry for the delay in my reply, life got a bit crazy with the holidays. 

It has been mentioned to me on this forum that I should get the full panel. I will definitely talk to my doctor, but we are still going full ahead with the endoscopy/colonoscopy next week regardless. Getting this partially positive genotyping has almost been a bit of a relief -- crazy to say but I'm hoping that means a possible diagnosis? At least it was negative.. I'm getting so beat up with test after test coming back normal (crazy, I should be thankful.. right?). 

You can see more of my history if interested in previous posts...

Thanks again and happy holidays!

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      127,982
    • Most Online (within 30 mins)
      7,748
    Amanda Jeanne
    Newest Member
    Amanda Jeanne
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.5k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      Contradicting length of time for gluten challenge - please help to ensure not getting false negative. Thank you!

      By trents · Posted

      Welcome to the forum, @WildFlower1! The reason you are seeing conflicting results when you research the length of time recommended for doing the "gluten challenge" is that the guidelines have recently been under revision. So there are two components: 1. amount of daily gluten consumption and 2. duration of that amount of daily gluten consumption Recently, the guidelines have been under revision because the medical community was sensing the previous standards were too relaxed, particularly in the daily amount of recommended gluten consumption. The more recent guidelines seem to be calling for higher amounts of daily gluten consumption over (perhaps) as shorter period of time. So, it is becoming a daily minimum of 10g of gluten daily (about the amount in 4-6 slices of wheat bread) for a minimum of two weeks. Personally, I would recommend that amount of consumption be extended from two weeks to four weeks to ensure valid testing. Your Immunoglobulin IgA at 1.25. Was that within normal range? If that one is low, you are IgA deficient and other IgA test results cannot be trusted. But regardless of whether or not you have celiac disease or NCGS (Non Celiac Gluten Sensitivity) the antidote is the same, namely, a gluten free diet. What would you do different if you had a more confident differential diagnosis? And there are other reasons for the development of osteopenia/osteoporosis that you probably should explore. Are you on any serious supplementation for D3 and magnesium?
    • WildFlower1
      Contradicting length of time for gluten challenge - please help to ensure not getting false negative. Thank you!

      By WildFlower1 · Posted

      The results of my blood tests after 4 weeks: *Tissue Transglutaminase Ab IgA —->   “<0.5 NEGATIVE” *Immunoglobulin IgA —-> “1.25” *Deamidated Gliadin peptide Ab IgG —-> “<0.5 NEGATIVE”    
    • WildFlower1
      Contradicting length of time for gluten challenge - please help to ensure not getting false negative. Thank you!

      By WildFlower1 · Posted

      Hi there, I have been scouring the forums, medical journals, celiac websites, speaking to my doctor and there seems to be a contradiction in the exact amount of time one must do the gluten challenge for a blood test. Let me please express my gratitude for taking your time to help! I will try and keep this short. In a nutshell, I am positive genetically for celiac. Previously for many years 10+ I have been on a strict gluten free diet. At a very young age, I had infertility, hair loss, low iron, stomach problems, neurological symptoms, continued low bone density etc. etc. all the symptoms that line up with celiac.  I could never get an “official diagnosis” because I was not eating gluten for years.   Recently, I had a bone density scan, and was shocked at the results. I am young and my low bone density is continuously lowering. This lead me  to seriously consider doing the celiac blood test to confirm if I actually have celiac. Years ago, I had an endoscopy and they did a biopsy saying it was negative for celiac - but I had been on a gluten free diet for years. Now, I asked my doctor if I can start the gluten challenge and get this over with. My doctor said two weeks then get the blood test. I have been having 2-3 pieces of bread daily. After four weeks of doing this, I went for the bloodwork - it came back negative for celiac. I am continuing to eat bread daily, it has now been over 6 weeks. I am not able to get an endoscopy. Please, from your experience how long really must I eat bread daily to ensure I do not get a false negative blood test for celiac? I have read up to 12 weeks. One doctor advised this is foolish to even do this gluten challenge as I am damaging my body. My other doctor said 2 weeks eat it, but it showed negative. But with my recent continuous lowering of bone density I personally need to rule celiac out.   Thank you VERY much for your help, I truly appreciate it!!
    • Soleihey
      Long Story Of Neurological Symptoms And Lowish Ferritin- Could It Be Celiacs?

      By Soleihey · Posted

      How are you now?
    • Scott Adams
      Conflicting results

      By Scott Adams · Posted

      It's possible he's in the early stages of celiac disease, and it has been caught before villi damage. The blood test results so far do indicate possible celiac disease, as well as his strong family history of celiac disease. If his symptoms get better on a gluten-free diet this would be another strong indication. Personally I think it's definitely better to proceed on the safe side and go gluten-free, rather than to risk severe villi damage and all that comes with it.
×
×
  • Create New...