I'm not a gastro doctor, but it seems reasonable to conclude that they would be able to spot any cancer-related issues during the endoscopy, at least in the areas that were checked.

Sorry cut out. Scott! Thanks You are really the master of this things! Thanks! One more question please, i did 2 EGD. In first EGD there was taken 2 samples from duodenum where they found MARSH 3b. In second EGD after 1year (i described in first post of this topic) they have taken multiple Samples from duodenum and jejunum and everything is ok (other than some of the samples is not readable but the explanation is very small and short, villi form good samples is OK and  they only found inflammation in lamina propria. Sorry, I am little overwhelm by this and scared so dr.google almost every-time frightens me. Would my GI and histology expert doctor see if there were like something serious like small bowel cancer or neoplasms(especially in histology)?  

Scott! Thanks You are really the master of this things! Thanks! One more question please, i did 2 EGD. In first EGD there was taken 2 samples from duodenum where they found MARSH 3b. In second EGD after 1year (i described in first post of this topic) they have taken multiple Samples from duodenum and jejenum. Would doctor GI and histology expert doctor see if there were like something serious like small bowel cancer or neoplasms(especially in histology)?

It's quite common for the mucosa to appear normal during an endoscopy in patients with celiac disease, especially in cases of Marsh 3a or 3b histological changes. Studies have shown that the "naked eye" assessment of the small intestine during endoscopy often misses the subtle changes associated with early or less severe villous atrophy. This is why multiple biopsies from different parts of the duodenum, including the bulb, are essential for a reliable diagnosis. Visual clues like scalloping, nodularity, or atrophy may not always be visible, particularly in patients with less advanced disease. In fact, research indicates that histology can reveal significant findings even when the mucosa looks normal on endoscopy, reinforcing the need for biopsy as the gold standard for diagnosing celiac disease. For anyone preparing to have an endoscopy, it's important to ensure that your gastroenterologist takes multiple biopsies from various areas to increase the likelihood of an accurate diagnosis.

Thanks Scott! One more question how many of celiac had normal mucosa on naked eye (i mean endoscopy) but histology was postive like marsh 3 a or b?